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- Opiorphin abstract "Opiorphin is an endogenous chemical compound first isolated from human saliva. Initial research with mice shows the compound has a painkilling effect greater than that of morphine. It works by stopping the normal breakup of enkephalins, natural pain-killing opioids in the spinal cord. It is a relatively simple molecule consisting of a five-amino acid polypeptide, Gln-Arg-Phe-Ser-Arg.Opiorphin pentapeptide originates from the N-terminal region of the protein PROL1 (proline-rich, lacrimal 1). Opiorphin inhibits three proteases: neutral ecto-endopeptidase (MME), ecto-aminopeptidase N (ANPEP)and perhaps also a dipeptidyl peptidase DPP3.Such action extends the duration of enkephalin effect where the natural pain killers are released physiologically in response to specific potentially painful stimuli, in contrast with administration of narcotics, which floods the entire body and causes many undesirable adverse reactions, including addiction liability and constipation.In addition, opiorphin may exert anti-depressive action.Therapeutic application of opiorphin in humans would require modifying the molecule to avoid its rapid degradation in the intestine and its poor penetration of the blood–brain barrier.".
- Opiorphin iupacName "(2S,5S,8S,11S,14S)-14,17-diamino-8-benzyl-2,11-bis(3-guanidinopropyl)-5-(hydroxymethyl)-4,7,10,13,17-pentaoxo-3,6,9,12-tetraazaheptadecan-1-oic acid".
- Opiorphin thumbnail Opiorphin.png?width=300.
- Opiorphin wikiPageID "7930039".
- Opiorphin wikiPageLength "7669".
- Opiorphin wikiPageOutDegree "27".
- Opiorphin wikiPageRevisionID "690956628".
- Opiorphin wikiPageWikiLink Alanine_aminopeptidase.
- Opiorphin wikiPageWikiLink Amino_acid.
- Opiorphin wikiPageWikiLink Analgesic.
- Opiorphin wikiPageWikiLink Arginine.
- Opiorphin wikiPageWikiLink Blood–brain_barrier.
- Opiorphin wikiPageWikiLink Category:Analgesics.
- Opiorphin wikiPageWikiLink Category:Enkephalinase_inhibitors.
- Opiorphin wikiPageWikiLink Category:Neuropeptides.
- Opiorphin wikiPageWikiLink Category:Opioid_peptides.
- Opiorphin wikiPageWikiLink Chemical_compound.
- Opiorphin wikiPageWikiLink DPP3.
- Opiorphin wikiPageWikiLink Enkephalin.
- Opiorphin wikiPageWikiLink Glutamine.
- Opiorphin wikiPageWikiLink Human.
- Opiorphin wikiPageWikiLink Morphine.
- Opiorphin wikiPageWikiLink Mouse.
- Opiorphin wikiPageWikiLink N-terminus.
- Opiorphin wikiPageWikiLink Neprilysin.
- Opiorphin wikiPageWikiLink Opioid.
- Opiorphin wikiPageWikiLink Peptide.
- Opiorphin wikiPageWikiLink Phenylalanine.
- Opiorphin wikiPageWikiLink Protease.
- Opiorphin wikiPageWikiLink RB-101.
- Opiorphin wikiPageWikiLink Racecadotril.
- Opiorphin wikiPageWikiLink Saliva.
- Opiorphin wikiPageWikiLink Serine.
- Opiorphin wikiPageWikiLink Spinal_cord.
- Opiorphin wikiPageWikiLinkText "Opiorphin".
- Opiorphin wikiPageWikiLinkText "opiorphin".
- Opiorphin imagefile "Opiorphin.png".
- Opiorphin iupacname "-1417".
- Opiorphin name "Opiorphin".
- Opiorphin othernames "Gln-Arg-Phe-Ser-Arg; (L)-Glutaminyl-(L)-arginyl-(L)-phenylalanyl-(L)-seryl-(L)-arginine".
- Opiorphin verifiedfields "changed".
- Opiorphin verifiedrevid "435332840".
- Opiorphin watchedfields "changed".
- Opiorphin wikiPageUsesTemplate Template:Cascite.
- Opiorphin wikiPageUsesTemplate Template:Chembox.
- Opiorphin wikiPageUsesTemplate Template:Chembox_Identifiers.
- Opiorphin wikiPageUsesTemplate Template:Chembox_Properties.
- Opiorphin wikiPageUsesTemplate Template:Chemspidercite.
- Opiorphin wikiPageUsesTemplate Template:Ebicite.
- Opiorphin wikiPageUsesTemplate Template:Opioidergics.
- Opiorphin wikiPageUsesTemplate Template:Reflist.
- Opiorphin wikiPageUsesTemplate Template:Stdinchicite.
- Opiorphin subject Category:Analgesics.
- Opiorphin subject Category:Enkephalinase_inhibitors.
- Opiorphin subject Category:Neuropeptides.
- Opiorphin subject Category:Opioid_peptides.
- Opiorphin hypernym Compound.
- Opiorphin type ChemicalCompound.
- Opiorphin type ChemicalSubstance.
- Opiorphin type Drug.
- Opiorphin type Analgesic.
- Opiorphin type Chemical.
- Opiorphin type Drug.
- Opiorphin type Hormone.
- Opiorphin type Inhibitor.
- Opiorphin type Neuropeptide.
- Opiorphin type ChemicalObject.
- Opiorphin type Thing.
- Opiorphin type Q11173.
- Opiorphin comment "Opiorphin is an endogenous chemical compound first isolated from human saliva. Initial research with mice shows the compound has a painkilling effect greater than that of morphine. It works by stopping the normal breakup of enkephalins, natural pain-killing opioids in the spinal cord. It is a relatively simple molecule consisting of a five-amino acid polypeptide, Gln-Arg-Phe-Ser-Arg.Opiorphin pentapeptide originates from the N-terminal region of the protein PROL1 (proline-rich, lacrimal 1).".
- Opiorphin label "Opiorphin".
- Opiorphin sameAs Q416529.
- Opiorphin sameAs Opiorphin.
- Opiorphin sameAs Opiorfina.
- Opiorphin sameAs Opiorphine.
- Opiorphin sameAs Opiorfina.
- Opiorphin sameAs オピオルフィン.
- Opiorphin sameAs Opiorfina.
- Opiorphin sameAs Opiorfina.
- Opiorphin sameAs m.026kft3.
- Opiorphin sameAs Opiorfin.
- Opiorphin sameAs Opiorfin.
- Opiorphin sameAs Q416529.
- Opiorphin wasDerivedFrom Opiorphin?oldid=690956628.
- Opiorphin depiction Opiorphin.png.
- Opiorphin isPrimaryTopicOf Opiorphin.
- Opiorphin name "Opiorphin".