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- ORAI1 abstract "Calcium release-activated calcium channel protein 1 is a calcium selective ion channel that in humans is encoded by the ORAI1 gene. Orai channels play an important role in the activation of T-lymphocytes. The loss of function mutation of Orai1 causes severe combined immunodeficiency (SCID) in humans The mammalian orai family has two additional homologs, orai2 and orai3. Orai proteins share no homology with any other ion channel family of any other known proteins. They have 4 transmembrane domains and form hexamers. Orai channels are activated upon the depletion of internal calcium stores, which is called the \"store-operated\" or the \"capacitative\" mechanism. They are molecular constituents of the \"calcium release activated calcium currents\" (ICRAC). Upon activation of phospholipase C by various cell surface receptors, inositol trisphosphate is formed that releases calcium from the endoplasmic reticulum. The decreased calcium concentration in the endoplasmic reticulum is sensed by the STIM1 protein. STIM1 clusters upon the depletion of the calcium stores and forms \"puncta\", and relocates near the plasma membrane, where it activates orai1 via protein protein interaction.".
- ORAI1 entrezgene "84876".
- ORAI1 wikiPageID "14035282".
- ORAI1 wikiPageLength "3503".
- ORAI1 wikiPageOutDegree "10".
- ORAI1 wikiPageRevisionID "682592395".
- ORAI1 wikiPageWikiLink Calcium_release_activated_channel.
- ORAI1 wikiPageWikiLink Endoplasmic_reticulum.
- ORAI1 wikiPageWikiLink Gene.
- ORAI1 wikiPageWikiLink Inositol_trisphosphate.
- ORAI1 wikiPageWikiLink Ion_channel.
- ORAI1 wikiPageWikiLink Phospholipase_C.
- ORAI1 wikiPageWikiLink STIM1.
- ORAI1 wikiPageWikiLink Severe_combined_immunodeficiency.
- ORAI1 wikiPageWikiLink T_cell.
- ORAI1 wikiPageWikiLink Transmembrane_protein.
- ORAI1 wikiPageWikiLinkText "ORAI".
- ORAI1 wikiPageWikiLinkText "ORAI1".
- ORAI1 wikiPageWikiLinkText "Orai".
- ORAI1 wikiPageUsesTemplate Template:Gene-12-stub.
- ORAI1 wikiPageUsesTemplate Template:PBB.
- ORAI1 wikiPageUsesTemplate Template:Reflist.
- ORAI1 hypernym Channel.
- ORAI1 type Biomolecule.
- ORAI1 type Protein.
- ORAI1 type TelevisionStation.
- ORAI1 type Thing.
- ORAI1 type Q206229.
- ORAI1 type Q8054.
- ORAI1 comment "Calcium release-activated calcium channel protein 1 is a calcium selective ion channel that in humans is encoded by the ORAI1 gene. Orai channels play an important role in the activation of T-lymphocytes. The loss of function mutation of Orai1 causes severe combined immunodeficiency (SCID) in humans The mammalian orai family has two additional homologs, orai2 and orai3. Orai proteins share no homology with any other ion channel family of any other known proteins.".
- ORAI1 label "ORAI1".
- ORAI1 sameAs Q18047835.
- ORAI1 sameAs m.03cpzp0.
- ORAI1 sameAs Q18047835.
- ORAI1 wasDerivedFrom ORAI1?oldid=682592395.
- ORAI1 isPrimaryTopicOf ORAI1.