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- Nutlin abstract "Nutlins are cis-imidazoline analogs which inhibit the interaction between mdm2 and tumour suppressor p53, and which were discovered by screening a chemical library by Vassilev et al. Nutlin-1, Nutlin-2 and Nutlin-3 were all identified in the same screen; however, Nutlin-3 is the compound most commonly used in anti-cancer studies. Inhibiting the interaction between mdm2 and p53 stabilizes p53, and is thought to selectively induce a growth-inhibiting state called senescence in cancer cells. These compounds are therefore thought to work best on tumors that contain normal or \"wild-type\" p53. Nutlin-3 has been shown to affect the production of p53 within minutes.The more potent of the two enantiomers, (−)-Nutlin-3, can now be synthesized in a highly enantioselective fashion.".
- Nutlin iupacName "(±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one".
- Nutlin thumbnail Nutlin3.PNG?width=300.
- Nutlin wikiPageID "21019434".
- Nutlin wikiPageLength "3291".
- Nutlin wikiPageOutDegree "6".
- Nutlin wikiPageRevisionID "670393588".
- Nutlin wikiPageWikiLink 2-Imidazoline.
- Nutlin wikiPageWikiLink Category:Imidazolines.
- Nutlin wikiPageWikiLink Enantiomer.
- Nutlin wikiPageWikiLink Mdm2.
- Nutlin wikiPageWikiLink P53.
- Nutlin wikiPageWikiLink Senescence.
- Nutlin wikiPageWikiLinkText "Nutlin".
- Nutlin wikiPageWikiLinkText "nutlin".
- Nutlin imagefile "Nutlin3.PNG".
- Nutlin iupacname "-4".
- Nutlin name "Nutlin 3".
- Nutlin othernames "Nutlin".
- Nutlin verifiedfields "changed".
- Nutlin verifiedrevid "433813167".
- Nutlin watchedfields "changed".
- Nutlin wikiPageUsesTemplate Template:Cascite.
- Nutlin wikiPageUsesTemplate Template:Chembox.
- Nutlin wikiPageUsesTemplate Template:Chembox_Hazards.
- Nutlin wikiPageUsesTemplate Template:Chembox_Identifiers.
- Nutlin wikiPageUsesTemplate Template:Chembox_Properties.
- Nutlin wikiPageUsesTemplate Template:Citation_needed.
- Nutlin wikiPageUsesTemplate Template:Ebicite.
- Nutlin wikiPageUsesTemplate Template:Organic-compound-stub.
- Nutlin wikiPageUsesTemplate Template:Reflist.
- Nutlin wikiPageUsesTemplate Template:Use_dmy_dates.
- Nutlin subject Category:Imidazolines.
- Nutlin hypernym Analogs.
- Nutlin type ChemicalCompound.
- Nutlin type ChemicalSubstance.
- Nutlin type Chemical.
- Nutlin type Heterocycle.
- Nutlin type Redirect.
- Nutlin type ChemicalObject.
- Nutlin type Thing.
- Nutlin type Q11173.
- Nutlin comment "Nutlins are cis-imidazoline analogs which inhibit the interaction between mdm2 and tumour suppressor p53, and which were discovered by screening a chemical library by Vassilev et al. Nutlin-1, Nutlin-2 and Nutlin-3 were all identified in the same screen; however, Nutlin-3 is the compound most commonly used in anti-cancer studies. Inhibiting the interaction between mdm2 and p53 stabilizes p53, and is thought to selectively induce a growth-inhibiting state called senescence in cancer cells.".
- Nutlin label "Nutlin".
- Nutlin sameAs Q7070462.
- Nutlin sameAs نوتلین.
- Nutlin sameAs Nutlina.
- Nutlin sameAs m.05b0kt_.
- Nutlin sameAs Nutlin.
- Nutlin sameAs Nutlin.
- Nutlin sameAs Q7070462.
- Nutlin wasDerivedFrom Nutlin?oldid=670393588.
- Nutlin depiction Nutlin3.PNG.
- Nutlin isPrimaryTopicOf Nutlin.
- Nutlin name "Nutlin 3".