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- Nucleus_raphe_magnus abstract "The nucleus raphe magnus (called the nucleus raphes magnus by Terminologia Anatomica and some scientific publications), is located directly rostral to the nucleus raphe obscurus, and receives input from the spinal cord and cerebellum. This makes the nucleus raphe magnus a likely candidate for part of the motor system; however, it seems to participate in the endogenous analgesia system. Mounting evidence suggests that the nucleus raphe magnus plays an important role in homeostatic regulation.The nucleus raphe magnus receives descending afferents from the periaqueductal grey matter, the paraventricular hypothalamic nucleus, central nucleus of the amygdala, lateral hypothalamic area, parvocellular reticular nucleus and the prelimbic, infralimbic, medial and lateral precentral cortices.All of these brain areas influence the main function of the nucleus raphe magnus. The main function of the nucleus raphe magnus is mostly pain mediation; in fact it sends projections to the dorsal horn of the spinal cord to directly inhibit pain. The nucleus raphe magnus releases serotonin when stimulated. Raphe-spinal neurons project to enkephalin releasing interneurons in the posterior horn of the spinal cord.The periaqueductal grey matter, an area of the brain involved in mediating analgesia, sends efferent connections to the nucleus raphe magnus when it is stimulated by opiates (endogenous or otherwise). Electrical stimulation of the PAG produces analgesia, as well as administration of morphine to the PAG or nucleus raphe magnus. The antinociceptic effects of electrical stimulation of the PAG can be blocked by administering naloxone, an opiate antagonist, to the nucleus raphe magnus. Similarly, afferent fibres from the spinothalamic tract synapse at the periaqueductal grey matter. This in turn is linked to the nucleus raphe magnus, which when stimulated directly inhibits pain fibers in the dorsal horn of the spinal cord, thus alleviating pain. All of this seems to indicate that the nucleus raphe magnus is part of the endogenous opiate system, and acts to inhibit pain in the spinal cord.".
- Nucleus_raphe_magnus brainInfoNumber "736".
- Nucleus_raphe_magnus brainInfoType "hier".
- Nucleus_raphe_magnus dorlandsPrefix "n_11".
- Nucleus_raphe_magnus dorlandsSuffix "12582800".
- Nucleus_raphe_magnus thumbnail Gray694.png?width=300.
- Nucleus_raphe_magnus wikiPageID "4469227".
- Nucleus_raphe_magnus wikiPageLength "4259".
- Nucleus_raphe_magnus wikiPageOutDegree "22".
- Nucleus_raphe_magnus wikiPageRevisionID "679502206".
- Nucleus_raphe_magnus wikiPageWikiLink Amygdala.
- Nucleus_raphe_magnus wikiPageWikiLink Analgesic.
- Nucleus_raphe_magnus wikiPageWikiLink Category:Medulla_oblongata.
- Nucleus_raphe_magnus wikiPageWikiLink Cerebellum.
- Nucleus_raphe_magnus wikiPageWikiLink Enkephalin.
- Nucleus_raphe_magnus wikiPageWikiLink Hypothalamus.
- Nucleus_raphe_magnus wikiPageWikiLink Motor_system.
- Nucleus_raphe_magnus wikiPageWikiLink Naloxone.
- Nucleus_raphe_magnus wikiPageWikiLink Nociceptor.
- Nucleus_raphe_magnus wikiPageWikiLink Nucleus_raphe_obscurus.
- Nucleus_raphe_magnus wikiPageWikiLink Paraventricular_nucleus_of_hypothalamus.
- Nucleus_raphe_magnus wikiPageWikiLink Parvocellular_reticular_nucleus.
- Nucleus_raphe_magnus wikiPageWikiLink Periaqueductal_gray.
- Nucleus_raphe_magnus wikiPageWikiLink Posterior_grey_column.
- Nucleus_raphe_magnus wikiPageWikiLink Raphe_nuclei.
- Nucleus_raphe_magnus wikiPageWikiLink Receptor_antagonist.
- Nucleus_raphe_magnus wikiPageWikiLink Serotonin.
- Nucleus_raphe_magnus wikiPageWikiLink Spinal_cord.
- Nucleus_raphe_magnus wikiPageWikiLink Spinothalamic_tract.
- Nucleus_raphe_magnus wikiPageWikiLink Terminologia_Anatomica.
- Nucleus_raphe_magnus wikiPageWikiLinkText "Nucleus raphe magnus".
- Nucleus_raphe_magnus wikiPageWikiLinkText "nucleus raphe magnus".
- Nucleus_raphe_magnus braininfonumber "736".
- Nucleus_raphe_magnus braininfotype "hier".
- Nucleus_raphe_magnus caption "Section of the medulla oblongata at about the middle of the olive.".
- Nucleus_raphe_magnus dorlandspre "n_11".
- Nucleus_raphe_magnus dorlandssuf "12582800".
- Nucleus_raphe_magnus latin "nucleus raphe magnus".
- Nucleus_raphe_magnus name "Nucleus raphe magnus".
- Nucleus_raphe_magnus neurolex "Nucleus raphe magnus".
- Nucleus_raphe_magnus neurolexid "birnlex_1363".
- Nucleus_raphe_magnus wikiPageUsesTemplate Template:Infobox_brain.
- Nucleus_raphe_magnus wikiPageUsesTemplate Template:Rhombencephalon.
- Nucleus_raphe_magnus subject Category:Medulla_oblongata.
- Nucleus_raphe_magnus type AnatomicalStructure.
- Nucleus_raphe_magnus type Brain.
- Nucleus_raphe_magnus type Thing.
- Nucleus_raphe_magnus type Q4936952.
- Nucleus_raphe_magnus comment "The nucleus raphe magnus (called the nucleus raphes magnus by Terminologia Anatomica and some scientific publications), is located directly rostral to the nucleus raphe obscurus, and receives input from the spinal cord and cerebellum. This makes the nucleus raphe magnus a likely candidate for part of the motor system; however, it seems to participate in the endogenous analgesia system.".
- Nucleus_raphe_magnus label "Nucleus raphe magnus".
- Nucleus_raphe_magnus sameAs Q17143534.
- Nucleus_raphe_magnus sameAs m.0c467r.
- Nucleus_raphe_magnus sameAs Q17143534.
- Nucleus_raphe_magnus wasDerivedFrom Nucleus_raphe_magnus?oldid=679502206.
- Nucleus_raphe_magnus depiction Gray694.png.
- Nucleus_raphe_magnus isPrimaryTopicOf Nucleus_raphe_magnus.
- Nucleus_raphe_magnus name "Nucleus raphe magnus".
- Nucleus_raphe_magnus name "nucleus raphe magnus".