Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Nosiheptide> ?p ?o }
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- Nosiheptide abstract "Nosiheptide is a thiopeptide antibiotic produced by the bacterium Streptomyces actuosus. It is classified, along with several others, as an e series thiopeptide characterized by a nitrogen containing, 6-membered heterocycle in a 2,3,5,6 substituted fashion central to multiple azoles (or azolines) and dehydroamino acids along with a macrocyclic core. Nosiheptide is constructed solely of proteinogenic amino acids and has ribosomal origin, making it a member of the ribosomally synthesized and posttranslationally modified peptide family of natural products. Thiopeptides such as nosiheptide have potent activity against various bacterial pathogens, primarily gram positive, including methicillin-resistant Staphylococcus aureus, penicillin-resistant Streptococcus pneumoniae, and vancomycin-resistant enterococci.Nosiheptide consists of 5 thiazole rings, a central tetrasubstituted pyridine moiety, and a bicyclic macrocycle, which includes a modified amino acid (from tryptophan) external to the initial peptide translated from the gene encoding it. It is used as a feed additive in the growth of poultry and hogs to promote growth and general health, although it has not been applied in human medicines due to low water solubility and poor resorption from the gastrointestinal tract. Nosiheptide and other thiopeptide's mechanism of action stems from the tight binding on the 50S ribosomal subunit and inhibiting the activities of elongation factors, preventing protein synthesis.".
- Nosiheptide thumbnail Nosiheptide.jpg?width=300.
- Nosiheptide wikiPageID "46935309".
- Nosiheptide wikiPageLength "7331".
- Nosiheptide wikiPageOutDegree "36".
- Nosiheptide wikiPageRevisionID "673682288".
- Nosiheptide wikiPageWikiLink Amino_acid.
- Nosiheptide wikiPageWikiLink Azole.
- Nosiheptide wikiPageWikiLink C-terminus.
- Nosiheptide wikiPageWikiLink Category:Antibiotics.
- Nosiheptide wikiPageWikiLink Category:Cyclic_peptides.
- Nosiheptide wikiPageWikiLink Cysteine.
- Nosiheptide wikiPageWikiLink Diels–Alder_reaction.
- Nosiheptide wikiPageWikiLink Elimination_reaction.
- Nosiheptide wikiPageWikiLink Enzyme.
- Nosiheptide wikiPageWikiLink Gastrointestinal_tract.
- Nosiheptide wikiPageWikiLink Gene.
- Nosiheptide wikiPageWikiLink Glutamic_acid.
- Nosiheptide wikiPageWikiLink Gram-positive_bacteria.
- Nosiheptide wikiPageWikiLink Heterocyclic_compound.
- Nosiheptide wikiPageWikiLink Macrocycle.
- Nosiheptide wikiPageWikiLink Mechanism_of_action.
- Nosiheptide wikiPageWikiLink Methicillin-resistant_Staphylococcus_aureus.
- Nosiheptide wikiPageWikiLink Pathogen.
- Nosiheptide wikiPageWikiLink Peptide.
- Nosiheptide wikiPageWikiLink Protein.
- Nosiheptide wikiPageWikiLink Protein_folding.
- Nosiheptide wikiPageWikiLink Proteinogenic_amino_acid.
- Nosiheptide wikiPageWikiLink Ribosomally_synthesized_and_post-translationally_modified_peptides.
- Nosiheptide wikiPageWikiLink Ribosome.
- Nosiheptide wikiPageWikiLink Serine.
- Nosiheptide wikiPageWikiLink Streptomyces_actuosus.
- Nosiheptide wikiPageWikiLink Thiazole.
- Nosiheptide wikiPageWikiLink Thioester.
- Nosiheptide wikiPageWikiLink Threonine.
- Nosiheptide wikiPageWikiLink Translation_(biology).
- Nosiheptide wikiPageWikiLink Tryptophan.
- Nosiheptide wikiPageWikiLink Vancomycin-resistant_Enterococcus.
- Nosiheptide wikiPageWikiLink File:Amino_acid_dehydration.jpg.
- Nosiheptide wikiPageWikiLink File:Precursor_Peptide_Nosiheptide.jpg.
- Nosiheptide wikiPageWikiLink File:Pyridine_formation.jpg.
- Nosiheptide wikiPageWikiLink File:Thiazole_formation1.jpg.
- Nosiheptide wikiPageWikiLinkText "nosiheptide".
- Nosiheptide imagefile "Nosiheptide.jpg".
- Nosiheptide imagesize "200".
- Nosiheptide wikiPageUsesTemplate Template:Chembox.
- Nosiheptide wikiPageUsesTemplate Template:Chembox_Hazards.
- Nosiheptide wikiPageUsesTemplate Template:Chembox_Identifiers.
- Nosiheptide wikiPageUsesTemplate Template:Chembox_Properties.
- Nosiheptide wikiPageUsesTemplate Template:Reflist.
- Nosiheptide subject Category:Antibiotics.
- Nosiheptide subject Category:Cyclic_peptides.
- Nosiheptide type ChemicalCompound.
- Nosiheptide type ChemicalSubstance.
- Nosiheptide type ChemicalObject.
- Nosiheptide type Thing.
- Nosiheptide type Q11173.
- Nosiheptide comment "Nosiheptide is a thiopeptide antibiotic produced by the bacterium Streptomyces actuosus. It is classified, along with several others, as an e series thiopeptide characterized by a nitrogen containing, 6-membered heterocycle in a 2,3,5,6 substituted fashion central to multiple azoles (or azolines) and dehydroamino acids along with a macrocyclic core.".
- Nosiheptide label "Nosiheptide".
- Nosiheptide sameAs Q20164429.
- Nosiheptide sameAs m.013ddctj.
- Nosiheptide sameAs Q20164429.
- Nosiheptide wasDerivedFrom Nosiheptide?oldid=673682288.
- Nosiheptide depiction Nosiheptide.jpg.
- Nosiheptide isPrimaryTopicOf Nosiheptide.