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- Nicholas_P._Restifo abstract "Nicholas P. Restifo (born 1960 in Ohio) is an American physician and immunologist. He is a tenured senior investigator in the intramural National Cancer Institute of the National Institutes of Health at Bethesda, Maryland.Dr. Restifo and his research team have made contributions to the fields of tumor immune-escape, virally encoded cancer vaccines, adoptive cell transfer for the treatment of cancer, and the biology of self/tumor-reactive T cells, with an emphasis on memory CD8+ T cells.More recently Restifo and colleagues identified a new class of intrinsic checkpoint inhibitors. They found that CISH, a member of the SOCS family of molecules to be induced by T cell receptor ligation (TCR) and negatively regulate it by targeting the critical signaling intermediate PLCG1 for degradation. The deletion of Cish in effector T cells has been shown to dramatically augment TCR signaling and subsequent effector cytokine release, proliferation and survival. The adoptive transfer of tumor-specific effector T cells knocked out or knocked down for CISH resulted in a significant increase in functional avidity and long-term tumor immunity. Surprisingly there was no changes in activity of Cish's purported target, STAT5. Thus Cish represents a new class of T-cell intrinsic immunologic checkpoints with the potential to radically enhance adoptive immunotherapies for cancer.".
- Nicholas_P._Restifo birthDate "1960".
- Nicholas_P._Restifo birthDate "1960-07-24".
- Nicholas_P._Restifo birthPlace Cleveland.
- Nicholas_P._Restifo birthPlace Ohio.
- Nicholas_P._Restifo birthYear "1960".
- Nicholas_P._Restifo occupation Nicholas_P._Restifo__1.
- Nicholas_P._Restifo wikiPageID "26906472".
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- Nicholas_P._Restifo wikiPageWikiLink Adoptive_cell_transfer.
- Nicholas_P._Restifo wikiPageWikiLink Bethesda,_Maryland.
- Nicholas_P._Restifo wikiPageWikiLink CISH.
- Nicholas_P._Restifo wikiPageWikiLink Cancer_vaccine.
- Nicholas_P._Restifo wikiPageWikiLink Category:1960_births.
- Nicholas_P._Restifo wikiPageWikiLink Category:American_physicians.
- Nicholas_P._Restifo wikiPageWikiLink Category:Cancer_researchers.
- Nicholas_P._Restifo wikiPageWikiLink Category:Johns_Hopkins_University_alumni.
- Nicholas_P._Restifo wikiPageWikiLink Category:Living_people.
- Nicholas_P._Restifo wikiPageWikiLink Category:New_York_University_alumni.
- Nicholas_P._Restifo wikiPageWikiLink Cleveland.
- Nicholas_P._Restifo wikiPageWikiLink Cytotoxic_T_cell.
- Nicholas_P._Restifo wikiPageWikiLink Immunology.
- Nicholas_P._Restifo wikiPageWikiLink Interleukin_15.
- Nicholas_P._Restifo wikiPageWikiLink Memory_T_cell.
- Nicholas_P._Restifo wikiPageWikiLink National_Cancer_Institute.
- Nicholas_P._Restifo wikiPageWikiLink National_Institutes_of_Health.
- Nicholas_P._Restifo wikiPageWikiLink Neoplasm.
- Nicholas_P._Restifo wikiPageWikiLink Ohio.
- Nicholas_P._Restifo wikiPageWikiLink PLCG1.
- Nicholas_P._Restifo wikiPageWikiLink Suppressor_of_cytokine_signalling.
- Nicholas_P._Restifo birthDate "1960-07-24".
- Nicholas_P._Restifo birthPlace Cleveland.
- Nicholas_P._Restifo birthPlace Ohio.
- Nicholas_P._Restifo dateOfBirth "1960".
- Nicholas_P._Restifo name "Nicholas P. Restifo".
- Nicholas_P._Restifo name "Restifo, Nicholas P.".
- Nicholas_P._Restifo nationality "American".
- Nicholas_P._Restifo occupation "Immunologist at the National Cancer Institute".
- Nicholas_P._Restifo placeOfBirth Cleveland.
- Nicholas_P._Restifo placeOfBirth Ohio.
- Nicholas_P._Restifo shortDescription "American physician".
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- Nicholas_P._Restifo description "American physician".
- Nicholas_P._Restifo description "American physician".
- Nicholas_P._Restifo subject Category:1960_births.
- Nicholas_P._Restifo subject Category:American_physicians.
- Nicholas_P._Restifo subject Category:Cancer_researchers.
- Nicholas_P._Restifo subject Category:Johns_Hopkins_University_alumni.
- Nicholas_P._Restifo subject Category:Living_people.
- Nicholas_P._Restifo subject Category:New_York_University_alumni.
- Nicholas_P._Restifo hypernym Physician.
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- Nicholas_P._Restifo comment "Nicholas P. Restifo (born 1960 in Ohio) is an American physician and immunologist. He is a tenured senior investigator in the intramural National Cancer Institute of the National Institutes of Health at Bethesda, Maryland.Dr.".
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- Nicholas_P._Restifo givenName "Nicholas P.".
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- Nicholas_P._Restifo name "Nicholas P. Restifo".
- Nicholas_P._Restifo name "Restifo, Nicholas P.".
- Nicholas_P._Restifo surname "Restifo".