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- Neutrophil_elastase abstract "Neutrophil elastase (EC 3.4.21.37, leukocyte elastase, ELANE, ELA2, elastase 2, neutrophil, elaszym, serine elastase) is a serine proteinase in the same family as chymotrypsin and has broad substrate specificity. Secreted by neutrophils and macrophages during inflammation, it destroys bacteria and host tissue. It also localizes to Neutrophil extracellular traps (NETs), via its high affinity for DNA, an unusual property for serine proteases.As with other serine proteinases it contains a charge relay system composed of the catalytic triad of histidine, aspartate, and serine residues that are dispersed throughout the primary sequence of the polypeptide but that are brought together in the three dimensional conformation of the folded protein. The gene encoding neutrophil elastase, ELA2, consists of five exons. Neutrophil elastase is closely related to other cytotoxic immune serine proteases, such as the granzymes and cathepsin G. It is more distantly related to the digestive CELA1.The neutrophil form of elastase (EC 3.4.21.37) is 218 amino acids long, with two asparagine-linked carbohydrate chains (see glycosylation). It is present in azurophil granules in the neutrophil cytoplasm. There appear to be two forms of neutrophil elastase, termed IIa and IIb.".
- Neutrophil_elastase entrezgene "1991".
- Neutrophil_elastase wikiPageExternalLink NBK1533.
- Neutrophil_elastase wikiPageID "6787434".
- Neutrophil_elastase wikiPageLength "7517".
- Neutrophil_elastase wikiPageOutDegree "28".
- Neutrophil_elastase wikiPageRevisionID "704476382".
- Neutrophil_elastase wikiPageWikiLink Alpha_2-antiplasmin.
- Neutrophil_elastase wikiPageWikiLink Amino_acid.
- Neutrophil_elastase wikiPageWikiLink Asparagine.
- Neutrophil_elastase wikiPageWikiLink Aspartic_acid.
- Neutrophil_elastase wikiPageWikiLink Azurophilic_granule.
- Neutrophil_elastase wikiPageWikiLink Carbohydrate.
- Neutrophil_elastase wikiPageWikiLink Catalytic_triad.
- Neutrophil_elastase wikiPageWikiLink Category:EC_3.4.21.
- Neutrophil_elastase wikiPageWikiLink Category:Extracellular_matrix_remodeling_enzymes.
- Neutrophil_elastase wikiPageWikiLink Cathepsin_G.
- Neutrophil_elastase wikiPageWikiLink Chronic_obstructive_pulmonary_disease.
- Neutrophil_elastase wikiPageWikiLink Chymotrypsin.
- Neutrophil_elastase wikiPageWikiLink Cytoplasm.
- Neutrophil_elastase wikiPageWikiLink Elastase.
- Neutrophil_elastase wikiPageWikiLink Exon.
- Neutrophil_elastase wikiPageWikiLink Gene.
- Neutrophil_elastase wikiPageWikiLink Glycosylation.
- Neutrophil_elastase wikiPageWikiLink Granzyme.
- Neutrophil_elastase wikiPageWikiLink Histidine.
- Neutrophil_elastase wikiPageWikiLink Neutropenia.
- Neutrophil_elastase wikiPageWikiLink Neutrophil_extracellular_traps.
- Neutrophil_elastase wikiPageWikiLink Neutrophil_granulocyte.
- Neutrophil_elastase wikiPageWikiLink Pancreatic_elastase.
- Neutrophil_elastase wikiPageWikiLink Protease.
- Neutrophil_elastase wikiPageWikiLink Protein–protein_interaction.
- Neutrophil_elastase wikiPageWikiLink Serine.
- Neutrophil_elastase wikiPageWikiLinkText "ELA-2".
- Neutrophil_elastase wikiPageWikiLinkText "ELA2".
- Neutrophil_elastase wikiPageWikiLinkText "ELANE".
- Neutrophil_elastase wikiPageWikiLinkText "Neutrophil elastase".
- Neutrophil_elastase wikiPageWikiLinkText "neutrophil elastase".
- Neutrophil_elastase wikiPageUsesTemplate Template:Cite_journal.
- Neutrophil_elastase wikiPageUsesTemplate Template:EC_number.
- Neutrophil_elastase wikiPageUsesTemplate Template:Enzymes.
- Neutrophil_elastase wikiPageUsesTemplate Template:MeshName.
- Neutrophil_elastase wikiPageUsesTemplate Template:PBB.
- Neutrophil_elastase wikiPageUsesTemplate Template:PDB_Gallery.
- Neutrophil_elastase wikiPageUsesTemplate Template:Portal_bar.
- Neutrophil_elastase wikiPageUsesTemplate Template:Refbegin.
- Neutrophil_elastase wikiPageUsesTemplate Template:Refend.
- Neutrophil_elastase wikiPageUsesTemplate Template:Reflist.
- Neutrophil_elastase wikiPageUsesTemplate Template:Serine_endopeptidases.
- Neutrophil_elastase subject Category:EC_3.4.21.
- Neutrophil_elastase subject Category:Extracellular_matrix_remodeling_enzymes.
- Neutrophil_elastase hypernym Proteinase.
- Neutrophil_elastase type Biomolecule.
- Neutrophil_elastase type Protein.
- Neutrophil_elastase type Thing.
- Neutrophil_elastase type Q206229.
- Neutrophil_elastase type Q8054.
- Neutrophil_elastase comment "Neutrophil elastase (EC 3.4.21.37, leukocyte elastase, ELANE, ELA2, elastase 2, neutrophil, elaszym, serine elastase) is a serine proteinase in the same family as chymotrypsin and has broad substrate specificity. Secreted by neutrophils and macrophages during inflammation, it destroys bacteria and host tissue.".
- Neutrophil_elastase label "Neutrophil elastase".
- Neutrophil_elastase sameAs Q14905648.
- Neutrophil_elastase sameAs Elastasi_neutrofila.
- Neutrophil_elastase sameAs m.0gnx7k.
- Neutrophil_elastase sameAs Leukocitna_elastaza.
- Neutrophil_elastase sameAs Leukocitna_elastaza.
- Neutrophil_elastase sameAs Q14905648.
- Neutrophil_elastase wasDerivedFrom Neutrophil_elastase?oldid=704476382.
- Neutrophil_elastase isPrimaryTopicOf Neutrophil_elastase.