Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Neprilysin> ?p ?o }
- Neprilysin abstract "Neprilysin (/ˌnɛprᵻˈlaɪsᵻn/ [3]), also known as membrane metallo-endopeptidase (MME), neutral endopeptidase (NEP), cluster of differentiation 10 (CD10), and common acute lymphoblastic leukemia antigen (CALLA) is an enzyme that in humans is encoded by the MME gene. Neprilysin is a zinc-dependent metalloprotease that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. It also degrades the amyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. Synthesized as a membrane-bound protein, the neprilysin ectodomain is released into the extracellular domain after it has been transported from the Golgi apparatus to the cell surface.Neprilysin is expressed in a wide variety of tissues and is particularly abundant in kidney. It is also a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL.Hematopoetic progenitors expressing CD10 are considered \"common lymphoid progenitors\", which means they can differentiate into T, B or natural killer cells. CD10 is of use in hematological diagnosis since it is expressed by early B, pro-B and pre-B lymphocytes, and by lymph node germinal centers. Hematologic diseases in which it is positive include ALL, angioimmunoblastic T cell lymphoma, Burkitt lymphoma, chronic myelogenous leukemia in blast crisis (90%), diffuse large B-cell lymphoma (variable), follicular center cells (70%), hairy cell leukemia (10%), and myeloma (some). It tends to be negative in acute myeloid leukemia, chronic lymphocytic leukemia, mantle cell lymphoma, and marginal zone lymphoma. CD10 is found on non-T ALL cells, which derive from pre-B lymphocytes, and in germinal center-related non-Hodgkin lymphoma such as Burkitt lymphoma and follicular lymphoma, but not on leukemia cells or lymphomas, which originate in more mature B cells.".
- Neprilysin entrezgene "4311".
- Neprilysin thumbnail Kidney_cd10_ihc.jpg?width=300.
- Neprilysin wikiPageExternalLink merops.cgi?id=M13.001.
- Neprilysin wikiPageExternalLink neprilysin.
- Neprilysin wikiPageID "9925108".
- Neprilysin wikiPageLength "22115".
- Neprilysin wikiPageOutDegree "91".
- Neprilysin wikiPageRevisionID "701530875".
- Neprilysin wikiPageWikiLink Acute_lymphoblastic_leukemia.
- Neprilysin wikiPageWikiLink Acute_myeloid_leukemia.
- Neprilysin wikiPageWikiLink Alzheimers_disease.
- Neprilysin wikiPageWikiLink Amyloid_beta.
- Neprilysin wikiPageWikiLink Analgesic.
- Neprilysin wikiPageWikiLink Angioimmunoblastic_T-cell_lymphoma.
- Neprilysin wikiPageWikiLink Antihypertensive_drug.
- Neprilysin wikiPageWikiLink Atrial_natriuretic_peptide.
- Neprilysin wikiPageWikiLink Atypical_fibroxanthoma.
- Neprilysin wikiPageWikiLink Autocrine_signalling.
- Neprilysin wikiPageWikiLink B-cell_chronic_lymphocytic_leukemia.
- Neprilysin wikiPageWikiLink Basal-cell_carcinoma.
- Neprilysin wikiPageWikiLink Bcl-2.
- Neprilysin wikiPageWikiLink Biomarker.
- Neprilysin wikiPageWikiLink Bombesin.
- Neprilysin wikiPageWikiLink Bradykinin.
- Neprilysin wikiPageWikiLink Burkitts_lymphoma.
- Neprilysin wikiPageWikiLink Cancer.
- Neprilysin wikiPageWikiLink Carcinoma.
- Neprilysin wikiPageWikiLink Category:Alzheimers_disease.
- Neprilysin wikiPageWikiLink Category:EC_3.4.24.
- Neprilysin wikiPageWikiLink Category:Tumor_markers.
- Neprilysin wikiPageWikiLink Ceropegia.
- Neprilysin wikiPageWikiLink Chronic_myelogenous_leukemia.
- Neprilysin wikiPageWikiLink Clear_cell_renal_cell_carcinoma.
- Neprilysin wikiPageWikiLink Cutaneous_tumor.
- Neprilysin wikiPageWikiLink Diffuse_large_B-cell_lymphoma.
- Neprilysin wikiPageWikiLink Endometrial_stromal_sarcoma.
- Neprilysin wikiPageWikiLink Endothelin.
- Neprilysin wikiPageWikiLink Enkephalin.
- Neprilysin wikiPageWikiLink Enzyme.
- Neprilysin wikiPageWikiLink Epithelioid_hemangioendothelioma.
- Neprilysin wikiPageWikiLink Follicular_lymphoma.
- Neprilysin wikiPageWikiLink Germinal_center.
- Neprilysin wikiPageWikiLink Glucagon.
- Neprilysin wikiPageWikiLink Golgi_apparatus.
- Neprilysin wikiPageWikiLink Hairy_cell_leukemia.
- Neprilysin wikiPageWikiLink Hemangioblastoma.
- Neprilysin wikiPageWikiLink Homology_(biology).
- Neprilysin wikiPageWikiLink Intraductal_papillary_mucinous_neoplasm.
- Neprilysin wikiPageWikiLink Kidney.
- Neprilysin wikiPageWikiLink Kniphofia.
- Neprilysin wikiPageWikiLink Knockout_mouse.
- Neprilysin wikiPageWikiLink List_of_histologic_stains_that_aid_in_diagnosis_of_cutaneous_conditions.
- Neprilysin wikiPageWikiLink Lung.
- Neprilysin wikiPageWikiLink Lung_cancer.
- Neprilysin wikiPageWikiLink MEROPS.
- Neprilysin wikiPageWikiLink Malignant_müllerian_mixed_tumor.
- Neprilysin wikiPageWikiLink Mantle_cell_lymphoma.
- Neprilysin wikiPageWikiLink Marginal_zone_B-cell_lymphoma.
- Neprilysin wikiPageWikiLink Melanoma.
- Neprilysin wikiPageWikiLink Membrane_protein.
- Neprilysin wikiPageWikiLink Metalloproteinase.
- Neprilysin wikiPageWikiLink Metastasis.
- Neprilysin wikiPageWikiLink Müllerian_adenosarcoma.
- Neprilysin wikiPageWikiLink Nervous_tissue.
- Neprilysin wikiPageWikiLink Neurotensin.
- Neprilysin wikiPageWikiLink Omapatrilat.
- Neprilysin wikiPageWikiLink Oxytocin.
- Neprilysin wikiPageWikiLink Pancreatic_mucinous_cystic_neoplasm.
- Neprilysin wikiPageWikiLink Pancreatic_tumor.
- Neprilysin wikiPageWikiLink Pavetta.
- Neprilysin wikiPageWikiLink Peptide_hormone.
- Neprilysin wikiPageWikiLink Plectranthus.
- Neprilysin wikiPageWikiLink Prodrug.
- Neprilysin wikiPageWikiLink Protein_folding.
- Neprilysin wikiPageWikiLink RB-101.
- Neprilysin wikiPageWikiLink Rate-determining_step.
- Neprilysin wikiPageWikiLink Redox.
- Neprilysin wikiPageWikiLink Renal_cell_carcinoma.
- Neprilysin wikiPageWikiLink Sacubitril.
- Neprilysin wikiPageWikiLink Sacubitrilat.
- Neprilysin wikiPageWikiLink Smooth_muscle_tumour.
- Neprilysin wikiPageWikiLink Solid_pseudopapillary_tumour.
- Neprilysin wikiPageWikiLink Somatostatin.
- Neprilysin wikiPageWikiLink Squamous-cell_carcinoma.
- Neprilysin wikiPageWikiLink Substance_P.
- Neprilysin wikiPageWikiLink Trichoblastoma.
- Neprilysin wikiPageWikiLink UK-414,495.
- Neprilysin wikiPageWikiLink Urothelial_tumor.
- Neprilysin wikiPageWikiLink Uterine_high-grade_leiomyosarcoma.
- Neprilysin wikiPageWikiLink Uterine_rhabdomyosarcoma.
- Neprilysin wikiPageWikiLink sacubitril.
- Neprilysin wikiPageWikiLink Zinc.
- Neprilysin wikiPageWikiLink File:Kidney_cd10_ihc.jpg.
- Neprilysin wikiPageWikiLinkText "CALLA".
- Neprilysin wikiPageWikiLinkText "MME".
- Neprilysin wikiPageWikiLinkText "Neprilysin".
- Neprilysin wikiPageWikiLinkText "Neutral endopeptidase".
- Neprilysin wikiPageWikiLinkText "neprilysin".
- Neprilysin wikiPageWikiLinkText "neutral endopeptidase".