Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Natalizumab> ?p ?o }
- Natalizumab abstract "Natalizumab is a humanized monoclonal antibody against the cell adhesion molecule α4-integrin. Natalizumab is used in the treatment of multiple sclerosis and Crohn's disease. It is co-marketed by Biogen Idec and Élan as Tysabri, and was previously named Antegren. Natalizumab is administered by intravenous infusion every 28 days. The drug is believed to work by reducing the ability of inflammatory immune cells to attach to and pass through the cell layers lining the intestines and blood–brain barrier. Natalizumab has proven effective in treating the symptoms of both diseases, preventing relapse, vision loss, cognitive decline and significantly improving quality of life in people with multiple sclerosis, as well as increasing rates of remission and preventing relapse in Crohn's disease.Natalizumab was approved in 2004 by the U.S. Food and Drug Administration (FDA) after years of testing. It was subsequently withdrawn from the market by its manufacturer after it was linked with three cases of the rare neurological condition progressive multifocal leukoencephalopathy (PML) when administered in combination with interferon beta-1a, another immunosuppressive drug often used in the treatment of multiple sclerosis. After a review of safety information and no further deaths, the drug was returned to the US market in 2006 under a special prescription program. As of June 2009, ten cases of PML were known. However, twenty-four cases of PML had been reported since its reintroduction by October 2009, showing a sharp rise in the number of fatalities and prompting a review of the chemical for human use by the European Medicines Agency. By January 2010, 31 cases of PML were attributed to natalizumab. The FDA did not withdraw the drug from the market because its clinical benefits outweigh the risks involved. In the European Union, it has been approved for human use only for the treatment of multiple sclerosis and only then as a monotherapy because the initial cases of PML, and later the fatalities, were said by the manufacturers to be linked to the use of previous medicines by the patients.Biogen Idec announced the initiation of the first clinical trial of natalizumab as a potential cancer treatment as of September 5, 2008.".
- Natalizumab atcPrefix "L04".
- Natalizumab atcSuffix "AA23".
- Natalizumab casNumber "189261-10-7".
- Natalizumab drugbank "DB00108".
- Natalizumab fdaUniiCode "3JB47N2Q2P".
- Natalizumab wikiPageExternalLink 019_2.html.
- Natalizumab wikiPageExternalLink tysabri_information_center.asp.
- Natalizumab wikiPageExternalLink www.tysabri.com.
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- Natalizumab wikiPageRevisionID "702322596".
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- Natalizumab wikiPageWikiLink Category:Immunosuppressants.
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- Natalizumab wikiPageWikiLink Cell_adhesion_molecule.
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- Natalizumab wikiPageWikiLink FDA_Fast_Track_Development_Program.
- Natalizumab wikiPageWikiLink Fatigue_(medical).
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- Natalizumab wikiPageWikiLink Gastrointestinal_tract.
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- Natalizumab wikiPageWikiLink Infection.
- Natalizumab wikiPageWikiLink Inflammation.
- Natalizumab wikiPageWikiLink Infliximab.
- Natalizumab wikiPageWikiLink Infusion.
- Natalizumab wikiPageWikiLink Integrin.
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- Natalizumab wikiPageWikiLink Intravenous_therapy.
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- Natalizumab wikiPageWikiLink JC_virus.
- Natalizumab wikiPageWikiLink Jaundice.
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- Natalizumab wikiPageWikiLink List_of_withdrawn_drugs.
- Natalizumab wikiPageWikiLink Liver.
- Natalizumab wikiPageWikiLink Liver_function_tests.
- Natalizumab wikiPageWikiLink Liver_transplantation.
- Natalizumab wikiPageWikiLink Lymphatic_system.
- Natalizumab wikiPageWikiLink Management_of_multiple_sclerosis.
- Natalizumab wikiPageWikiLink Mechanism_of_action.
- Natalizumab wikiPageWikiLink Melanoma.
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- Natalizumab wikiPageWikiLink Monoclonal_antibody.
- Natalizumab wikiPageWikiLink Multiple_sclerosis.
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- Natalizumab wikiPageWikiLink Organ_(anatomy).
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- Natalizumab wikiPageWikiLink Progressive_multifocal_leukoencephalopathy.
- Natalizumab wikiPageWikiLink Quality_of_life.
- Natalizumab wikiPageWikiLink Randomized_controlled_trial.
- Natalizumab wikiPageWikiLink Rituximab.
- Natalizumab wikiPageWikiLink Sequela.
- Natalizumab wikiPageWikiLink T_cell.
- Natalizumab wikiPageWikiLink Therapy.
- Natalizumab wikiPageWikiLink Tumor_necrosis_factor_alpha.