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- Naluzotan abstract "Naluzotan (INN, USAN; PRX-00023) is a serotonergic drug of the phenylpiperazine class that was under investigation by EPIX Pharmaceuticals Inc for the treatment of generalized anxiety disorder and major depressive disorder. It acts as a selective and potent 5-HT1A receptor partial agonist, readily stimulating prolactin responses, though it has also been found to bind to and activate the σ receptor. Naluzotan was well tolerated in clinical trials, with more patients in the control group dropping out due to adverse effects than in the active group in one study. The most frequently reported side effect was headache in 15% of patients (compared to 10% for placebo). In addition, naluzotan demonstrated significant antidepressant and anxiolytic effects as per the HAM-D and MADRS and the HAM-A, respectively, in some trials, but in others it did not. In the end it was not found to be significantly superior enough to placebo and development was stopped.".
- Naluzotan atcPrefix "None".
- Naluzotan casNumber "740873-06-7".
- Naluzotan fdaUniiCode "LQ54E5B4EW".
- Naluzotan iupacName "N-(3-{4-[4-(1-cyclohexylmethanesulfonamido)butyl]piperazin-1-yl}phenyl)acetamide".
- Naluzotan pubchem "11430856".
- Naluzotan thumbnail PRX-00023_structure.png?width=300.
- Naluzotan wikiPageID "22627114".
- Naluzotan wikiPageLength "5676".
- Naluzotan wikiPageOutDegree "30".
- Naluzotan wikiPageRevisionID "674581223".
- Naluzotan wikiPageWikiLink 5-HT1A_receptor.
- Naluzotan wikiPageWikiLink Adverse_effect.
- Naluzotan wikiPageWikiLink Antidepressant.
- Naluzotan wikiPageWikiLink Anxiolytic.
- Naluzotan wikiPageWikiLink Binding_selectivity.
- Naluzotan wikiPageWikiLink Category:5-HT1A_agonists.
- Naluzotan wikiPageWikiLink Category:Acetanilides.
- Naluzotan wikiPageWikiLink Category:Piperazines.
- Naluzotan wikiPageWikiLink Category:Sulfonamides.
- Naluzotan wikiPageWikiLink Clinical_trial.
- Naluzotan wikiPageWikiLink Drug.
- Naluzotan wikiPageWikiLink Epix_Pharmaceuticals.
- Naluzotan wikiPageWikiLink Generalized_anxiety_disorder.
- Naluzotan wikiPageWikiLink Hamilton_Anxiety_Rating_Scale.
- Naluzotan wikiPageWikiLink Hamilton_Rating_Scale_for_Depression.
- Naluzotan wikiPageWikiLink Headache.
- Naluzotan wikiPageWikiLink International_nonproprietary_name.
- Naluzotan wikiPageWikiLink Major_depressive_disorder.
- Naluzotan wikiPageWikiLink Montgomery–Åsberg_Depression_Rating_Scale.
- Naluzotan wikiPageWikiLink Mouth.
- Naluzotan wikiPageWikiLink Partial_agonist.
- Naluzotan wikiPageWikiLink Phenylpiperazine.
- Naluzotan wikiPageWikiLink Placebo.
- Naluzotan wikiPageWikiLink Potency_(pharmacology).
- Naluzotan wikiPageWikiLink Prolactin.
- Naluzotan wikiPageWikiLink Receptor_(biochemistry).
- Naluzotan wikiPageWikiLink Serotonergic.
- Naluzotan wikiPageWikiLink Sigma_receptor.
- Naluzotan wikiPageWikiLink United_States_Adopted_Name.
- Naluzotan wikiPageWikiLinkText "Naluzotan".
- Naluzotan wikiPageWikiLinkText "naluzotan".
- Naluzotan atcPrefix "None".
- Naluzotan c "23".
- Naluzotan casNumber "740873".
- Naluzotan chemspiderid "9605731".
- Naluzotan h "38".
- Naluzotan iupacName "N-acetamide".
- Naluzotan molecularWeight "450.638".
- Naluzotan n "4".
- Naluzotan o "3".
- Naluzotan pubchem "11430856".
- Naluzotan routesOfAdministration Mouth.
- Naluzotan s "1".
- Naluzotan smiles "O=CC".
- Naluzotan stdinchi "1".
- Naluzotan stdinchikey "SPWZXWDPAWDKQE-UHFFFAOYSA-N".
- Naluzotan unii "LQ54E5B4EW".
- Naluzotan verifiedrevid "444039968".
- Naluzotan wikiPageUsesTemplate Template:Drugbox.
- Naluzotan wikiPageUsesTemplate Template:Fdacite.
- Naluzotan wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- Naluzotan wikiPageUsesTemplate Template:Piperazines.
- Naluzotan wikiPageUsesTemplate Template:Reflist.
- Naluzotan wikiPageUsesTemplate Template:Serotonergics.
- Naluzotan wikiPageUsesTemplate Template:Sigmaergics.
- Naluzotan subject Category:5-HT1A_agonists.
- Naluzotan subject Category:Acetanilides.
- Naluzotan subject Category:Piperazines.
- Naluzotan subject Category:Sulfonamides.
- Naluzotan hypernym Drug.
- Naluzotan type ChemicalSubstance.
- Naluzotan type Drug.
- Naluzotan type Agonist.
- Naluzotan type Amide.
- Naluzotan type Antidepressant.
- Naluzotan type Drug.
- Naluzotan type Heterocycle.
- Naluzotan type Psychoanaleptic.
- Naluzotan type Sulfonamide.
- Naluzotan type ChemicalObject.
- Naluzotan type Thing.
- Naluzotan type Q8386.
- Naluzotan comment "Naluzotan (INN, USAN; PRX-00023) is a serotonergic drug of the phenylpiperazine class that was under investigation by EPIX Pharmaceuticals Inc for the treatment of generalized anxiety disorder and major depressive disorder. It acts as a selective and potent 5-HT1A receptor partial agonist, readily stimulating prolactin responses, though it has also been found to bind to and activate the σ receptor.".
- Naluzotan label "Naluzotan".
- Naluzotan sameAs Q6961039.
- Naluzotan sameAs m.05zkhx6.
- Naluzotan sameAs PRX-00023.
- Naluzotan sameAs PRX-00023.
- Naluzotan sameAs Q6961039.
- Naluzotan wasDerivedFrom Naluzotan?oldid=674581223.
- Naluzotan depiction PRX-00023_structure.png.
- Naluzotan isPrimaryTopicOf Naluzotan.