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- Naked_cuticle_1 abstract "Naked cuticle 1 (NKD1) is a human gene that encodes the protein Nkd1, a member of the Naked cuticle (Nkd) family of proteins that regulate the Wnt signaling pathway. Insects typically have a single Nkd gene, whereas there are two Nkd genes, Nkd1 and Nkd2, in most vertebrates studied to date (zebrafish appear to have additional homologous genes such as Nkd3). Nkd1 binds to the Dishevelled (Dvl) family of proteins (DVL1, DVL2, DVL3), and specific NKD1 mutations identified in DNA mismatch repair deficient colon cancer that disrupt Nkd1/Dvl binding implicate these mutations as a cause of increased Wnt signaling in approximately 1% of human colon cancer, the majority of which have increased Wnt signaling due to mutations the adenomatous polyposis coli (APC), AXIN2, or rarely the beta-catenin genes.".
- Naked_cuticle_1 wikiPageID "30856177".
- Naked_cuticle_1 wikiPageLength "2529".
- Naked_cuticle_1 wikiPageOutDegree "13".
- Naked_cuticle_1 wikiPageRevisionID "483905032".
- Naked_cuticle_1 wikiPageWikiLink AXIN2.
- Naked_cuticle_1 wikiPageWikiLink Adenomatous_polyposis_coli.
- Naked_cuticle_1 wikiPageWikiLink Beta-catenin.
- Naked_cuticle_1 wikiPageWikiLink Category:Human_proteins.
- Naked_cuticle_1 wikiPageWikiLink Colorectal_cancer.
- Naked_cuticle_1 wikiPageWikiLink DNA_mismatch_repair.
- Naked_cuticle_1 wikiPageWikiLink DVL1.
- Naked_cuticle_1 wikiPageWikiLink DVL2.
- Naked_cuticle_1 wikiPageWikiLink DVL3.
- Naked_cuticle_1 wikiPageWikiLink Dishevelled.
- Naked_cuticle_1 wikiPageWikiLink Naked_cuticle.
- Naked_cuticle_1 wikiPageWikiLink Naked_cuticle_2.
- Naked_cuticle_1 wikiPageWikiLink Wnt_signaling_pathway.
- Naked_cuticle_1 wikiPageWikiLinkText "NKD1".
- Naked_cuticle_1 wikiPageWikiLinkText "Naked cuticle 1".
- Naked_cuticle_1 subject Category:Human_proteins.
- Naked_cuticle_1 hypernym Gene.
- Naked_cuticle_1 type Protein.
- Naked_cuticle_1 comment "Naked cuticle 1 (NKD1) is a human gene that encodes the protein Nkd1, a member of the Naked cuticle (Nkd) family of proteins that regulate the Wnt signaling pathway. Insects typically have a single Nkd gene, whereas there are two Nkd genes, Nkd1 and Nkd2, in most vertebrates studied to date (zebrafish appear to have additional homologous genes such as Nkd3).".
- Naked_cuticle_1 label "Naked cuticle 1".
- Naked_cuticle_1 sameAs Q18048023.
- Naked_cuticle_1 sameAs m.0ggbbbl.
- Naked_cuticle_1 sameAs Q18048023.
- Naked_cuticle_1 wasDerivedFrom Naked_cuticle_1?oldid=483905032.
- Naked_cuticle_1 isPrimaryTopicOf Naked_cuticle_1.