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- NEDD4L abstract "Neural precursor cell expressed developmentally downregulated gene 4-like (NEDD4L) or NEDD4-2 (NEDD4-2) is an enzyme (ubiquitin ligase) of the NEDD4 family. In human the protein is encoded by the NEDD4L gene. In mouse the protein is commonly known as NEDD4-2 and the gene Nedd4-2.NEDD4-2 has been shown to ubiquitinate and therefore down regulate the epithelial sodium channel (ENaC) in the collecting ducts of the kidneys, therefore opposing the actions of aldosterone and increasing salt excretion. In Liddle's Syndrome NEDD4 is unable to bind to the ENaC and lead to salt retention and hypertension occur.NEDD4L belongs to the NEDD4 family of E3 HECT domain ubiquitin ligases. It is the closest homologue of NEDD4, the prototypic member of the family and probably arose as a result of gene duplication. While NEDD4 orthologues are present in all eukaryotes, NEDD4L proteins are limited to vertebrates. NEDD4L proteins are known to be involved in regulating many membrane proteins via ubiquitination and endocytosis.NEDD4L protein is expressed widely. The primary targets of NEDD4-2 include the epithelial sodium channel (ENaC), the Na+-Cl- co-transporter (NCC), and the voltage gated sodium channels (Navs), although additional targets are predicted from in vitro studies. NEDD4-2 gene in mice is essential for animal survival and the polymorphisms in NEDD4L are associated with human hypertension.".
- NEDD4L entrezgene "23327".
- NEDD4L wikiPageID "14157274".
- NEDD4L wikiPageLength "25673".
- NEDD4L wikiPageOutDegree "15".
- NEDD4L wikiPageRevisionID "698893451".
- NEDD4L wikiPageWikiLink Aldosterone.
- NEDD4L wikiPageWikiLink Category:Human_proteins.
- NEDD4L wikiPageWikiLink Collecting_duct_system.
- NEDD4L wikiPageWikiLink Enzyme.
- NEDD4L wikiPageWikiLink Epithelial_sodium_channel.
- NEDD4L wikiPageWikiLink Gene.
- NEDD4L wikiPageWikiLink Kidney.
- NEDD4L wikiPageWikiLink Liddles_syndrome.
- NEDD4L wikiPageWikiLink NEDD4.
- NEDD4L wikiPageWikiLink Osmoregulation.
- NEDD4L wikiPageWikiLink Protein–protein_interaction.
- NEDD4L wikiPageWikiLink SCNN1A.
- NEDD4L wikiPageWikiLink Ubiquitin.
- NEDD4L wikiPageWikiLinkText "NEDD4L".
- NEDD4L wikiPageUsesTemplate Template:Cite_journal.
- NEDD4L wikiPageUsesTemplate Template:PBB.
- NEDD4L wikiPageUsesTemplate Template:PDB_Gallery.
- NEDD4L wikiPageUsesTemplate Template:Refbegin.
- NEDD4L wikiPageUsesTemplate Template:Refend.
- NEDD4L wikiPageUsesTemplate Template:Reflist.
- NEDD4L subject Category:Human_proteins.
- NEDD4L hypernym Enzyme.
- NEDD4L type Biomolecule.
- NEDD4L type Protein.
- NEDD4L type Thing.
- NEDD4L type Q206229.
- NEDD4L type Q8054.
- NEDD4L comment "Neural precursor cell expressed developmentally downregulated gene 4-like (NEDD4L) or NEDD4-2 (NEDD4-2) is an enzyme (ubiquitin ligase) of the NEDD4 family. In human the protein is encoded by the NEDD4L gene.".
- NEDD4L label "NEDD4L".
- NEDD4L sameAs Q18037094.
- NEDD4L sameAs m.03cw9gq.
- NEDD4L sameAs Q18037094.
- NEDD4L wasDerivedFrom NEDD4L?oldid=698893451.
- NEDD4L isPrimaryTopicOf NEDD4L.