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- Myosin-light-chain_phosphatase abstract "Myosin light-chain phosphatase, more commonly called myosin phosphatase (EC 3.1.3.53), is an enzyme (specifically a serine/threonine-specific protein phosphatase) that dephosphorylates the regulatory light chain of myosin II. This dephosphorylation reaction occurs in smooth muscle tissue and initiates the relaxation process of the muscle cells. Thus, myosin phosphatase undoes the muscle contraction process initiated by myosin light-chain kinase. The enzyme is composed of three subunits: the catalytic region (protein phosphatase 1, or PP1), the myosin binding subunit (MYPT1), and a third subunit (M20) of unknown function. The catalytic region uses two manganese ions as catalysts to dephosphorylate the light-chains on myosin, which causes a conformational change in the myosin and relaxes the muscle. The enzyme is highly conserved and is found in all organisms’ smooth muscle tissue. While it is known that myosin phosphatase is regulated by rho-associated protein kinases, there is current debate about whether other molecules, such as arachidonic acid and cAMP, also regulate the enzyme.".
- Myosin-light-chain_phosphatase ecNumber "3.1.3.53".
- Myosin-light-chain_phosphatase thumbnail Complex_between_PP1_and_a_portion_of_MYPT1_structure.png?width=300.
- Myosin-light-chain_phosphatase wikiPageID "14456966".
- Myosin-light-chain_phosphatase wikiPageLength "14042".
- Myosin-light-chain_phosphatase wikiPageOutDegree "41".
- Myosin-light-chain_phosphatase wikiPageRevisionID "703370086".
- Myosin-light-chain_phosphatase wikiPageWikiLink Actin.
- Myosin-light-chain_phosphatase wikiPageWikiLink Arachidonic_acid.
- Myosin-light-chain_phosphatase wikiPageWikiLink Asthma.
- Myosin-light-chain_phosphatase wikiPageWikiLink Calcium.
- Myosin-light-chain_phosphatase wikiPageWikiLink Category:EC_3.1.3.
- Myosin-light-chain_phosphatase wikiPageWikiLink Category:Enzymes_of_known_structure.
- Myosin-light-chain_phosphatase wikiPageWikiLink Cell_division.
- Myosin-light-chain_phosphatase wikiPageWikiLink Cyclic_adenosine_monophosphate.
- Myosin-light-chain_phosphatase wikiPageWikiLink Cytosol.
- Myosin-light-chain_phosphatase wikiPageWikiLink Dephosphorylation.
- Myosin-light-chain_phosphatase wikiPageWikiLink Endoplasmic_reticulum.
- Myosin-light-chain_phosphatase wikiPageWikiLink Enzyme.
- Myosin-light-chain_phosphatase wikiPageWikiLink Enzyme_inhibitor.
- Myosin-light-chain_phosphatase wikiPageWikiLink Erectile_dysfunction.
- Myosin-light-chain_phosphatase wikiPageWikiLink Eukaryote.
- Myosin-light-chain_phosphatase wikiPageWikiLink Glycogen.
- Myosin-light-chain_phosphatase wikiPageWikiLink Glycogen_synthase.
- Myosin-light-chain_phosphatase wikiPageWikiLink Hypertension.
- Myosin-light-chain_phosphatase wikiPageWikiLink Manganese.
- Myosin-light-chain_phosphatase wikiPageWikiLink Muscle_contraction.
- Myosin-light-chain_phosphatase wikiPageWikiLink Myosin.
- Myosin-light-chain_phosphatase wikiPageWikiLink Myosin_light-chain_kinase.
- Myosin-light-chain_phosphatase wikiPageWikiLink PPP1R12A.
- Myosin-light-chain_phosphatase wikiPageWikiLink Phosphate.
- Myosin-light-chain_phosphatase wikiPageWikiLink Phosphorus.
- Myosin-light-chain_phosphatase wikiPageWikiLink Protein_phosphatase_1.
- Myosin-light-chain_phosphatase wikiPageWikiLink threonine_phosphatase.
- Myosin-light-chain_phosphatase wikiPageWikiLink RHOA.
- Myosin-light-chain_phosphatase wikiPageWikiLink ROCK1.
- Myosin-light-chain_phosphatase wikiPageWikiLink Rho-associated_protein_kinase.
- Myosin-light-chain_phosphatase wikiPageWikiLink Serine.
- Myosin-light-chain_phosphatase wikiPageWikiLink Smooth_muscle_tissue.
- Myosin-light-chain_phosphatase wikiPageWikiLink Telokin.
- Myosin-light-chain_phosphatase wikiPageWikiLink File:PP1_and_a_portion_of_MYPT1_with_the_Manganese_ion_catalysts_3D.png.
- Myosin-light-chain_phosphatase wikiPageWikiLink File:PP1_mechanism_for_myosin_phosphatase.png.
- Myosin-light-chain_phosphatase wikiPageWikiLinkText "Myosin-light-chain phosphatase".
- Myosin-light-chain_phosphatase wikiPageWikiLinkText "myosin light-chain phosphatase".
- Myosin-light-chain_phosphatase caption "Structure of complex between PP1 and a portion of MYPT1, generated from 1s70".
- Myosin-light-chain_phosphatase casNumber "86417".
- Myosin-light-chain_phosphatase ecNumber "3.1".
- Myosin-light-chain_phosphatase goCode "50115".
- Myosin-light-chain_phosphatase iubmbEcNumber "3".
- Myosin-light-chain_phosphatase name "Myosin Light-Chain Phosphatase".
- Myosin-light-chain_phosphatase wikiPageUsesTemplate Template:Cite_journal.
- Myosin-light-chain_phosphatase wikiPageUsesTemplate Template:EC_number.
- Myosin-light-chain_phosphatase wikiPageUsesTemplate Template:Enzymes.
- Myosin-light-chain_phosphatase wikiPageUsesTemplate Template:Esterases.
- Myosin-light-chain_phosphatase wikiPageUsesTemplate Template:Infobox_enzyme.
- Myosin-light-chain_phosphatase wikiPageUsesTemplate Template:Main.
- Myosin-light-chain_phosphatase wikiPageUsesTemplate Template:Portal_bar.
- Myosin-light-chain_phosphatase wikiPageUsesTemplate Template:Refbegin.
- Myosin-light-chain_phosphatase wikiPageUsesTemplate Template:Refend.
- Myosin-light-chain_phosphatase wikiPageUsesTemplate Template:Reflist.
- Myosin-light-chain_phosphatase subject Category:EC_3.1.3.
- Myosin-light-chain_phosphatase subject Category:Enzymes_of_known_structure.
- Myosin-light-chain_phosphatase hypernym Enzyme.
- Myosin-light-chain_phosphatase type Biomolecule.
- Myosin-light-chain_phosphatase type Enzyme.
- Myosin-light-chain_phosphatase type Protein.
- Myosin-light-chain_phosphatase type Thing.
- Myosin-light-chain_phosphatase type Q206229.
- Myosin-light-chain_phosphatase type Q8047.
- Myosin-light-chain_phosphatase comment "Myosin light-chain phosphatase, more commonly called myosin phosphatase (EC 3.1.3.53), is an enzyme (specifically a serine/threonine-specific protein phosphatase) that dephosphorylates the regulatory light chain of myosin II. This dephosphorylation reaction occurs in smooth muscle tissue and initiates the relaxation process of the muscle cells. Thus, myosin phosphatase undoes the muscle contraction process initiated by myosin light-chain kinase.".
- Myosin-light-chain_phosphatase label "Myosin-light-chain phosphatase".
- Myosin-light-chain_phosphatase sameAs Q1956701.
- Myosin-light-chain_phosphatase sameAs Myosin-Leichte-Ketten-Phosphatase.
- Myosin-light-chain_phosphatase sameAs m.03d43hc.
- Myosin-light-chain_phosphatase sameAs (Miozin-laki-lanac)_fosfataza.
- Myosin-light-chain_phosphatase sameAs (Miozin-laki-lanac)_fosfataza.
- Myosin-light-chain_phosphatase sameAs Q1956701.
- Myosin-light-chain_phosphatase wasDerivedFrom Myosin-light-chain_phosphatase?oldid=703370086.
- Myosin-light-chain_phosphatase depiction Complex_between_PP1_and_a_portion_of_MYPT1_structure.png.
- Myosin-light-chain_phosphatase isPrimaryTopicOf Myosin-light-chain_phosphatase.
- Myosin-light-chain_phosphatase name "Myosin Light-Chain Phosphatase".