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- Moxestrol abstract "Moxestrol (INN) (brand name Surestryl), also known as 11β-methoxy-17α-ethinyl-1,3,5(10)-estratriene-3,17β-diol or as 11β-methoxy-17α-ethinylestradiol, is a synthetic, steroidal estrogen that is or was used in Europe for the treatment of menopausal symptoms. It is the 11β-methoxy derivative of ethinyl estradiol, and is one of the most potent estrogens known, being some 10–100 times more potent than estradiol and about 5-fold more potent than ethinyl estradiol. The very high potency of moxestrol has been attributed to its high affinity for the estrogen receptor (ER), its negligible plasma binding to sex hormone binding globulin and low binding to serum albumin, and its lower relative rate of metabolization. In contrast to estradiol, which has roughly the same affinity for both ERs (Ki 0.12 nM and 0.15 nM, respectively), moxestrol possesses several-fold selectivity for ERα (Ki = 0.50 nM) over ERβ (Ki = 2.6 nM).".
- Moxestrol atcPrefix "G03".
- Moxestrol atcSuffix "CB04".
- Moxestrol bioavailability "33.0".
- Moxestrol casNumber "34816-55-2".
- Moxestrol iupacName "(8S,9S,11S,13S,14S,17R)-17-ethynyl-11-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol".
- Moxestrol pubchem "11954041".
- Moxestrol thumbnail Moxestrol_structure.svg?width=300.
- Moxestrol wikiPageID "26781475".
- Moxestrol wikiPageLength "5028".
- Moxestrol wikiPageOutDegree "23".
- Moxestrol wikiPageRevisionID "698365659".
- Moxestrol wikiPageWikiLink Category:Alkynes.
- Moxestrol wikiPageWikiLink Category:Steroids.
- Moxestrol wikiPageWikiLink Category:Synthetic_estrogens.
- Moxestrol wikiPageWikiLink Estradiol.
- Moxestrol wikiPageWikiLink Estrogen.
- Moxestrol wikiPageWikiLink Estrogen_receptor.
- Moxestrol wikiPageWikiLink Estrogen_receptor_alpha.
- Moxestrol wikiPageWikiLink Estrogen_receptor_beta.
- Moxestrol wikiPageWikiLink Ethinyl_estradiol.
- Moxestrol wikiPageWikiLink Europe.
- Moxestrol wikiPageWikiLink International_nonproprietary_name.
- Moxestrol wikiPageWikiLink Ligand_(biochemistry).
- Moxestrol wikiPageWikiLink Menopause.
- Moxestrol wikiPageWikiLink Mestranol.
- Moxestrol wikiPageWikiLink Metabolism.
- Moxestrol wikiPageWikiLink Oral_administration.
- Moxestrol wikiPageWikiLink Organic_compound.
- Moxestrol wikiPageWikiLink Plasma_protein_binding.
- Moxestrol wikiPageWikiLink Potency_(pharmacology).
- Moxestrol wikiPageWikiLink Quinestrol.
- Moxestrol wikiPageWikiLink Serum_albumin.
- Moxestrol wikiPageWikiLink Sex_hormone-binding_globulin.
- Moxestrol wikiPageWikiLink Steroid.
- Moxestrol wikiPageWikiLinkText "Moxestrol".
- Moxestrol wikiPageWikiLinkText "moxestrol".
- Moxestrol atcPrefix "G03".
- Moxestrol atcSuffix "CB04".
- Moxestrol bioavailability "33.0".
- Moxestrol c "21".
- Moxestrol casNumber "34816".
- Moxestrol chemspiderid "10128336".
- Moxestrol eliminationHalfLife "29519.999999999996".
- Moxestrol h "26".
- Moxestrol inchi "InChI=1S/C21H26O3/c1-4-2110-9-17-16-7-5-13-11-146-8-15191812-202/h1,6,8,11,16-19,22-23H,5,7,9-10,12H2,2-3H3/t16-,17-,18-,19+,20-,21-/m0/s1".
- Moxestrol inchikey "MTMZZIPTQITGCY-OLGWUGKESA-N".
- Moxestrol iupacName "-17".
- Moxestrol legalStatus "Rx-only".
- Moxestrol molecularWeight "326.42934".
- Moxestrol o "3".
- Moxestrol pregnancyCategory "X".
- Moxestrol proteinBound "Minimal".
- Moxestrol pubchem "11954041".
- Moxestrol routesOfAdministration Oral_administration.
- Moxestrol smiles "CC12CCOC".
- Moxestrol synonyms "R-2858, RU-2858, NSC-118191".
- Moxestrol tradename "Surestryl".
- Moxestrol wikiPageUsesTemplate Template:Drugbox.
- Moxestrol wikiPageUsesTemplate Template:Estrogenics.
- Moxestrol wikiPageUsesTemplate Template:Estrogens.
- Moxestrol wikiPageUsesTemplate Template:Genito-urinary-drug-stub.
- Moxestrol wikiPageUsesTemplate Template:Reflist.
- Moxestrol wikiPageUsesTemplate Template:Steroid-stub.
- Moxestrol subject Category:Alkynes.
- Moxestrol subject Category:Steroids.
- Moxestrol subject Category:Synthetic_estrogens.
- Moxestrol hypernym Synthetic.
- Moxestrol type ChemicalSubstance.
- Moxestrol type Drug.
- Moxestrol type Alkyne.
- Moxestrol type Chemical.
- Moxestrol type Drug.
- Moxestrol type Estrogen.
- Moxestrol type Hormone.
- Moxestrol type Hydrocarbon.
- Moxestrol type Redirect.
- Moxestrol type ChemicalObject.
- Moxestrol type Thing.
- Moxestrol type Q8386.
- Moxestrol comment "Moxestrol (INN) (brand name Surestryl), also known as 11β-methoxy-17α-ethinyl-1,3,5(10)-estratriene-3,17β-diol or as 11β-methoxy-17α-ethinylestradiol, is a synthetic, steroidal estrogen that is or was used in Europe for the treatment of menopausal symptoms. It is the 11β-methoxy derivative of ethinyl estradiol, and is one of the most potent estrogens known, being some 10–100 times more potent than estradiol and about 5-fold more potent than ethinyl estradiol.".
- Moxestrol label "Moxestrol".
- Moxestrol sameAs Q10858994.
- Moxestrol sameAs موکسسترول.
- Moxestrol sameAs m.0bs636n.
- Moxestrol sameAs Moksestrol.
- Moxestrol sameAs Moksestrol.
- Moxestrol sameAs Q10858994.
- Moxestrol wasDerivedFrom Moxestrol?oldid=698365659.
- Moxestrol depiction Moxestrol_structure.svg.
- Moxestrol isPrimaryTopicOf Moxestrol.