Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Morpholino> ?p ?o }
- Morpholino abstract "A morpholino, also known as a morpholino oligomer and as a phosphorodiamidate morpholino oligomer (PMO), is type of oligomer molecule (colloquially, an oligo) used in molecular biology to modify gene expression. The molecular structure has a backbone of methylenemorpholine rings and phosphorodiamidate linkages. Morpholinos block access of other molecules to small (~25 base) specific sequences of the base-pairing surfaces of ribonucleic acid (RNA). Morpholinos are used as research tools for reverse genetics by knocking down gene function. They are being studied for application in medicine.This article discusses only the morpholino antisense oligomers, which are nucleic acid analogs. The word \"morpholino\" can occur in other chemical names, referring to chemicals containing a six-membered morpholine ring. To help avoid confusion with other morpholine-containing molecules, when describing oligos \"Morpholino\" is often capitalized as a trade name, but this usage is not consistent throughout the scientific literature.Gene knockdown is achieved by preventing cells from making a targeted protein. Morpholinos can also modify the splicing of pre-mRNA. Knocking down gene expression is a powerful method for learning about the function of a particular protein; in a similar manner, causing a specific exon to be spliced out of a protein can help to determine the function of the protein moiety encoded by that exon or can sometimes knock down the protein activity altogether. These molecules have been applied to studies in several model organisms, including mice, zebrafish, frogs, and sea urchins.Morpholinos are in development as pharmaceutical therapeutics targeted against pathogenic organisms such as bacteria or viruses and for amelioration of genetic diseases. These synthetic oligos were conceived by James E. Summerton (Gene Tools) and developed in collaboration with Dwight D. Weller (formerly Antivirals, renamed AVI BioPharma, renamed Sarepta Therapeutics).".
- Morpholino thumbnail MorpholinoHeteroduplex.png?width=300.
- Morpholino wikiPageExternalLink issuetoc.
- Morpholino wikiPageID "1078762".
- Morpholino wikiPageLength "32189".
- Morpholino wikiPageOutDegree "134".
- Morpholino wikiPageRevisionID "706105823".
- Morpholino wikiPageWikiLink Angioplasty.
- Morpholino wikiPageWikiLink Apoptosis.
- Morpholino wikiPageWikiLink Bacteria.
- Morpholino wikiPageWikiLink Base_pair.
- Morpholino wikiPageWikiLink Category:Molecular_genetics.
- Morpholino wikiPageWikiLink Category:Morpholines.
- Morpholino wikiPageWikiLink Category:Nucleic_acids.
- Morpholino wikiPageWikiLink Category:Phosphoramidates.
- Morpholino wikiPageWikiLink Cell-penetrating_peptide.
- Morpholino wikiPageWikiLink Cell_(biology).
- Morpholino wikiPageWikiLink Cell_culture.
- Morpholino wikiPageWikiLink Cell_death.
- Morpholino wikiPageWikiLink Cell_membrane.
- Morpholino wikiPageWikiLink Cell_nucleus.
- Morpholino wikiPageWikiLink Cellular_differentiation.
- Morpholino wikiPageWikiLink Central_nervous_system.
- Morpholino wikiPageWikiLink Chicken.
- Morpholino wikiPageWikiLink Clinical_trial.
- Morpholino wikiPageWikiLink Coding_region.
- Morpholino wikiPageWikiLink Current_Protocols.
- Morpholino wikiPageWikiLink Cytoplasm.
- Morpholino wikiPageWikiLink DNA.
- Morpholino wikiPageWikiLink DNA_methylation.
- Morpholino wikiPageWikiLink Deoxyribose.
- Morpholino wikiPageWikiLink Duchenne_muscular_dystrophy.
- Morpholino wikiPageWikiLink Electroporation.
- Morpholino wikiPageWikiLink Embryo.
- Morpholino wikiPageWikiLink Endosome.
- Morpholino wikiPageWikiLink Endothelium.
- Morpholino wikiPageWikiLink Eukaryote.
- Morpholino wikiPageWikiLink Eukaryotic_initiation_factor.
- Morpholino wikiPageWikiLink Exon.
- Morpholino wikiPageWikiLink Exonic_splicing_enhancer.
- Morpholino wikiPageWikiLink Five_prime_untranslated_region.
- Morpholino wikiPageWikiLink Frameshift_mutation.
- Morpholino wikiPageWikiLink Gel_electrophoresis.
- Morpholino wikiPageWikiLink Gene.
- Morpholino wikiPageWikiLink Gene_Tools.
- Morpholino wikiPageWikiLink Gene_expression.
- Morpholino wikiPageWikiLink Gene_knockdown.
- Morpholino wikiPageWikiLink Genetic_code.
- Morpholino wikiPageWikiLink Genetic_disorder.
- Morpholino wikiPageWikiLink Heteroduplex.
- Morpholino wikiPageWikiLink Human.
- Morpholino wikiPageWikiLink In_situ_hybridization.
- Morpholino wikiPageWikiLink Inflammation.
- Morpholino wikiPageWikiLink Innate_immune_system.
- Morpholino wikiPageWikiLink Interferon.
- Morpholino wikiPageWikiLink Intron.
- Morpholino wikiPageWikiLink Ion.
- Morpholino wikiPageWikiLink MicroRNA.
- Morpholino wikiPageWikiLink Microinjection.
- Morpholino wikiPageWikiLink Model_organism.
- Morpholino wikiPageWikiLink Molecular_biology.
- Morpholino wikiPageWikiLink Molecule.
- Morpholino wikiPageWikiLink Morphant.
- Morpholino wikiPageWikiLink Morpholine.
- Morpholino wikiPageWikiLink Mouse.
- Morpholino wikiPageWikiLink Mummichog.
- Morpholino wikiPageWikiLink Muscle.
- Morpholino wikiPageWikiLink NF-κB.
- Morpholino wikiPageWikiLink Nuclease.
- Morpholino wikiPageWikiLink Nucleic_acid_analogue.
- Morpholino wikiPageWikiLink Nucleophile.
- Morpholino wikiPageWikiLink Oligomer.
- Morpholino wikiPageWikiLink Oligonucleotide_synthesis.
- Morpholino wikiPageWikiLink Organogenesis.
- Morpholino wikiPageWikiLink P53.
- Morpholino wikiPageWikiLink PH.
- Morpholino wikiPageWikiLink Pathogen.
- Morpholino wikiPageWikiLink Pharmacology.
- Morpholino wikiPageWikiLink Phenocopy.
- Morpholino wikiPageWikiLink Phenotype.
- Morpholino wikiPageWikiLink Phosphate.
- Morpholino wikiPageWikiLink Phosphoramidate.
- Morpholino wikiPageWikiLink Polyethylenimine.
- Morpholino wikiPageWikiLink Precursor_mRNA.
- Morpholino wikiPageWikiLink Protein.
- Morpholino wikiPageWikiLink RNA.
- Morpholino wikiPageWikiLink RNA_splicing.
- Morpholino wikiPageWikiLink Reverse_genetics.
- Morpholino wikiPageWikiLink Reverse_transcription_polymerase_chain_reaction.
- Morpholino wikiPageWikiLink Ribosome.
- Morpholino wikiPageWikiLink Ribozyme.
- Morpholino wikiPageWikiLink Sarepta_Therapeutics.
- Morpholino wikiPageWikiLink Scientific_control.
- Morpholino wikiPageWikiLink Sea_urchin.
- Morpholino wikiPageWikiLink Small_interfering_RNA.
- Morpholino wikiPageWikiLink SnRNP.
- Morpholino wikiPageWikiLink Somite.
- Morpholino wikiPageWikiLink Start_codon.
- Morpholino wikiPageWikiLink Tissue_(biology).
- Morpholino wikiPageWikiLink Toll-like_receptor.