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- Monobody abstract "Monobodies are synthetic binding proteins that are constructed using a fibronectin type III domain (FN3) as a molecular scaffold. Monobodies are simple and robust alternative to antibodies for creating target-binding proteins. The term \"monobody\" was coined in 1998 by the Koide group who published the first paper demonstrating the monobody concept using the tenth FN3 domain of human fibronectin.Monobodies are generated from combinatorial libraries in which portions of the FN3 scaffold are diversified using molecular display and directed evolution technologies such as phage display, mRNA display and yeast surface display. A large number of monobodies that have high affinity and high specificity to their respective targets have been reported.Monobodies belong to the class of molecules collectively called antibody mimics (or Antibody mimetics) and alternative scaffolds that aim to overcome shortcomings of natural antibody molecules. A major advantage of monobodies over conventional antibodies is that monobodies can readily be used as genetically encoded intracellular inhibitors, that is you can express a monobody inhibitor in a cell of choice by simply transfecting the cell with a monobody expression vector. This is because of unique characteristics of the underlying FN3 scaffold: small (~90 residues), stable, easy to produce, and its lack of disulfide bonds that makes it possible to produce functional monobodies regardless of the redox potential of the cellular environment, including the reducing environment of the cytoplasm and nucleus. In contrast, most antibodies and antibody fragments dependend on disulfide bonds formation and they must be produced under an oxidizing environment.The monobody technology has been adopted in the biotechnology industry, most notably by Adnexus, a biotechnology company which has been part of Bristol-Myers Squibb since 2007 under the name of Adnectins (originally as Trinectins by its predecesor, Phylos). An example is pegdinetanib (Angiocept), an antagonist of vascular endothelial growth factor receptor 2 (VEGFR-2), which has entered Phase II clinical trials investigating the treatment of glioblastoma in October 2007.".
- Monobody thumbnail PDB_1ttg_EBI.jpg?width=300.
- Monobody wikiPageID "26902451".
- Monobody wikiPageLength "8754".
- Monobody wikiPageOutDegree "23".
- Monobody wikiPageRevisionID "697628444".
- Monobody wikiPageWikiLink Adnexus.
- Monobody wikiPageWikiLink Amino_acid.
- Monobody wikiPageWikiLink Antibody.
- Monobody wikiPageWikiLink Antibody_mimetics.
- Monobody wikiPageWikiLink Atomic_mass_unit.
- Monobody wikiPageWikiLink Beta_sheet.
- Monobody wikiPageWikiLink Bristol-Myers_Squibb.
- Monobody wikiPageWikiLink Category:Antibody_mimetics.
- Monobody wikiPageWikiLink Clinical_trial.
- Monobody wikiPageWikiLink Complementarity_determining_region.
- Monobody wikiPageWikiLink Disulfide.
- Monobody wikiPageWikiLink Extracellular.
- Monobody wikiPageWikiLink Fibronectin.
- Monobody wikiPageWikiLink Fibronectin_type_III_domain.
- Monobody wikiPageWikiLink Glioblastoma_multiforme.
- Monobody wikiPageWikiLink Immunoglobulin_G.
- Monobody wikiPageWikiLink Kinase_insert_domain_receptor.
- Monobody wikiPageWikiLink Molecular_mass.
- Monobody wikiPageWikiLink Pegdinetanib.
- Monobody wikiPageWikiLink Receptor_antagonist.
- Monobody wikiPageWikiLink Single-domain_antibody.
- Monobody wikiPageWikiLink File:PDB_1ttg_EBI.jpg.
- Monobody wikiPageWikiLink File:PDB_2rhe_EBI.jpg.
- Monobody wikiPageWikiLinkText "Monobodies".
- Monobody wikiPageWikiLinkText "Monobody".
- Monobody wikiPageWikiLinkText "monobody".
- Monobody wikiPageUsesTemplate Template:Engineered_antibodies.
- Monobody wikiPageUsesTemplate Template:PDB.
- Monobody wikiPageUsesTemplate Template:Reflist.
- Monobody subject Category:Antibody_mimetics.
- Monobody hypernym Proteins.
- Monobody type Drug.
- Monobody type Protein.
- Monobody type Drug.
- Monobody type Redirect.
- Monobody comment "Monobodies are synthetic binding proteins that are constructed using a fibronectin type III domain (FN3) as a molecular scaffold. Monobodies are simple and robust alternative to antibodies for creating target-binding proteins.".
- Monobody label "Monobody".
- Monobody sameAs Q1944957.
- Monobody sameAs Monobody.
- Monobody sameAs m.0bmj5d0.
- Monobody sameAs Q1944957.
- Monobody wasDerivedFrom Monobody?oldid=697628444.
- Monobody depiction PDB_1ttg_EBI.jpg.
- Monobody isPrimaryTopicOf Monobody.