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- Molecular_pathological_epidemiology abstract "Molecular pathological epidemiology (abbreviated as MPE, also called \"molecular pathologic epidemiology\") is a specific discipline of epidemiology, and also that of pathology. It is defined as \"epidemiology of molecular pathology and heterogeneity of disease\". MPE represents an integrative interdisciplinary (transdisciplinary or multidisciplinary) science of molecular pathology and epidemiology. Pathology and epidemiology share the same goal of elucidating etiology of disease, and integrative MPE approach aims to achieve this goal simultaneously at molecular, individual, and population levels. Researchers who conduct MPE research are referred to as molecular pathological epidemiologist (or molecular pathologic epidemiologist). Typically, MPE refers to research which utilizes tissue pathology resource and data within existing epidemiology studies. MPE started as analysis of disease patients with data of risk factors (such as smoking) and molecular pathologic findings (such as KRAS oncogene mutation in lung cancer). As advancement of technology and molecular pathology has become rapid, application of molecular pathology to epidemiology is increasingly widespread.Accumulating evidence including data from The Cancer Genome Atlas projects indicates that disease evolution represents inherently heterogeneous process. Essentially, each individual has a unique disease process different from any other individual (“the unique disease principle”), considering uniqueness of the exposome and its unique influence on molecular pathologic process in each individual. In clinical medicine, this concept has been adopted along with the terms of precision medicine and personalized medicine. Studies to examine the relationship between an exposure and molecular pathologic signature of disease (particularly, cancer) became increasingly common throughout the 1990s and early 2000s. However, the use of molecular pathology in epidemiology posed unique challenges including lack of standardized methodologies and guidelines as well as paucity of interdisciplinary experts and training programs. MPE research necessitates new conceptual framework and methodologies (epidemiological method) because MPE examines heterogeneity in an outcome variable.In this context, the field of MPE gradually formed. The term \"molecular pathological epidemiology\" was used by Shuji Ogino and Meir Stampfer in 2010. Specific principles of MPE have developed since 2010. The MPE paradigm has been globally adopted and in widespread use, and has been a subject in international conferences. Molecular epidemiology broadly encompasses MPE and conventional-type molecular epidemiology with the use of traditional disease designation system.In MPE, investigators dissect interrelationships between exposures (e.g., environmental, dietary, lifestyle and genetic factors); alterations in cellular or extracellular molecules (disease molecular signatures); and evolution and progression of disease. As disease molecular signatures, investigators can analyze genome, methylome, epigenome, metabolome, transcriptome, proteome, microbiome, immunity, and interactome. In particular, a putative risk factor can be linked to specific molecular signatures of a disease to support a causal association. Thus, MPE can advance the area of causal inference. The MPE research enables identification of a new biomarker for potential clinical utility, using a large-scale population based data (e.g., PIK3CA mutation in colorectal cancer to select patients for aspirin therapy). The MPE approach can be used as one of next steps from genome-wide association study (GWAS), which is termed “GWAS-MPE approach”. Detailed disease endpoint phenotyping can be conducted by means of molecular pathology or surrogate histopathology or immunohistochemistry analysis of diseased tissues and cells within GWAS. As an alternative approach, potential risk variants identified by GWAS can be examined in combination with molecular pathology analysis on diseased tissues. This GWAS-MPE approach can give not only more precise effect estimates, even larger effects, for specific molecular subtypes of the disease, but also insights into pathogenesis by linking genetic variants to molecular pathologic signatures of disease. Since molecular diagnostics is becoming routine clinical practice in the era of precision medicine, routine molecular pathology data can be utilized in a wide spectrum of epidemiologic research.".
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- Molecular_pathological_epidemiology wikiPageWikiLink Aspirin.
- Molecular_pathological_epidemiology wikiPageWikiLink Biomarker.
- Molecular_pathological_epidemiology wikiPageWikiLink Category:Epidemiology.
- Molecular_pathological_epidemiology wikiPageWikiLink Category:Pathology.
- Molecular_pathological_epidemiology wikiPageWikiLink Category:Public_health.
- Molecular_pathological_epidemiology wikiPageWikiLink Causal_inference.
- Molecular_pathological_epidemiology wikiPageWikiLink Colorectal_cancer.
- Molecular_pathological_epidemiology wikiPageWikiLink Conceptual_framework.
- Molecular_pathological_epidemiology wikiPageWikiLink DNA_methylation.
- Molecular_pathological_epidemiology wikiPageWikiLink Discipline_(academia).
- Molecular_pathological_epidemiology wikiPageWikiLink Epidemiological_method.
- Molecular_pathological_epidemiology wikiPageWikiLink Epidemiology.
- Molecular_pathological_epidemiology wikiPageWikiLink Epigenome.
- Molecular_pathological_epidemiology wikiPageWikiLink Etiology.
- Molecular_pathological_epidemiology wikiPageWikiLink Evidence-based_medicine.
- Molecular_pathological_epidemiology wikiPageWikiLink Exposome.
- Molecular_pathological_epidemiology wikiPageWikiLink Genome.
- Molecular_pathological_epidemiology wikiPageWikiLink Genome-wide_association_study.
- Molecular_pathological_epidemiology wikiPageWikiLink Histopathology.
- Molecular_pathological_epidemiology wikiPageWikiLink Homogeneity_and_heterogeneity.
- Molecular_pathological_epidemiology wikiPageWikiLink Immunity_(medical).
- Molecular_pathological_epidemiology wikiPageWikiLink Immunohistochemistry.
- Molecular_pathological_epidemiology wikiPageWikiLink Interactome.
- Molecular_pathological_epidemiology wikiPageWikiLink Interdisciplinarity.
- Molecular_pathological_epidemiology wikiPageWikiLink KRAS.
- Molecular_pathological_epidemiology wikiPageWikiLink Metabolome.
- Molecular_pathological_epidemiology wikiPageWikiLink Microbiota.
- Molecular_pathological_epidemiology wikiPageWikiLink Molecular_diagnostics.
- Molecular_pathological_epidemiology wikiPageWikiLink Molecular_epidemiology.
- Molecular_pathological_epidemiology wikiPageWikiLink Molecular_medicine.
- Molecular_pathological_epidemiology wikiPageWikiLink Molecular_pathology.
- Molecular_pathological_epidemiology wikiPageWikiLink Multidisciplinary_approach.
- Molecular_pathological_epidemiology wikiPageWikiLink Mutation.
- Molecular_pathological_epidemiology wikiPageWikiLink Oncogene.
- Molecular_pathological_epidemiology wikiPageWikiLink Outcome_(probability).
- Molecular_pathological_epidemiology wikiPageWikiLink P110α.
- Molecular_pathological_epidemiology wikiPageWikiLink Paradigm.
- Molecular_pathological_epidemiology wikiPageWikiLink Pathogenesis.
- Molecular_pathological_epidemiology wikiPageWikiLink Pathology.
- Molecular_pathological_epidemiology wikiPageWikiLink Personalized_medicine.
- Molecular_pathological_epidemiology wikiPageWikiLink Precision_medicine.
- Molecular_pathological_epidemiology wikiPageWikiLink Proteome.
- Molecular_pathological_epidemiology wikiPageWikiLink Public_health.
- Molecular_pathological_epidemiology wikiPageWikiLink Shuji_Ogino.
- Molecular_pathological_epidemiology wikiPageWikiLink Systems_biology.
- Molecular_pathological_epidemiology wikiPageWikiLink The_Cancer_Genome_Atlas.
- Molecular_pathological_epidemiology wikiPageWikiLink Tissue_(biology).
- Molecular_pathological_epidemiology wikiPageWikiLink Transcriptome.
- Molecular_pathological_epidemiology wikiPageWikiLink Transdisciplinarity.
- Molecular_pathological_epidemiology wikiPageWikiLinkText "Molecular pathological epidemiology".
- Molecular_pathological_epidemiology wikiPageWikiLinkText "molecular pathological epidemiologist".
- Molecular_pathological_epidemiology wikiPageWikiLinkText "molecular pathological epidemiology".
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- Molecular_pathological_epidemiology subject Category:Epidemiology.
- Molecular_pathological_epidemiology subject Category:Pathology.
- Molecular_pathological_epidemiology subject Category:Public_health.
- Molecular_pathological_epidemiology hypernym Discipline.
- Molecular_pathological_epidemiology type Sport.
- Molecular_pathological_epidemiology comment "Molecular pathological epidemiology (abbreviated as MPE, also called \"molecular pathologic epidemiology\") is a specific discipline of epidemiology, and also that of pathology. It is defined as \"epidemiology of molecular pathology and heterogeneity of disease\". MPE represents an integrative interdisciplinary (transdisciplinary or multidisciplinary) science of molecular pathology and epidemiology.".
- Molecular_pathological_epidemiology label "Molecular pathological epidemiology".
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- Molecular_pathological_epidemiology sameAs 분자병리역학.
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- Molecular_pathological_epidemiology sameAs Q17069638.
- Molecular_pathological_epidemiology wasDerivedFrom Molecular_pathological_epidemiology?oldid=708104872.
- Molecular_pathological_epidemiology isPrimaryTopicOf Molecular_pathological_epidemiology.