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- Mitochondrial_calcium_uniporter abstract "The mitochondrial calcium uniporter (MCU) is a transmembrane protein that allows the passage of calcium ions from a cell's cytosol into mitochondria. Its activity is regulated by MICU1 and MICU2, which together with the MCU make up the mitochondrial calcium uniporter complex.The MCU is one of the primary sources of mitochondria uptake of calcium, and flow is dependent on membrane potential of the inner mitochondrial membrane and the concentration of calcium in the cytosol relative to the concentration in the mitochondria. Balancing calcium concentration is necessary to increase the cell's energy supply and regulate cell death. Calcium is balanced through the MCU in conjunction with the sodium-calcium exchanger.The MCU has a very low affinity for calcium, so the cytosolic calcium concentration needs to be approximately 5-10 uM for significant transport of calcium into the mitochondria. Mitochondria are closely associated with the endoplasmic reticulum (ER), which contains stores of cellular calcium ions for calcium signaling. The presence of 1,4,5-triphosphate (IP3) triggers the release of calcium from these intracellular stores, which creates microdomains of high calcium concentration between the ER and the mitochondria, creating the conditions for the MCU to take up calcium.Ruthenium red and Ru360 are typical reagents used to experimentally block the MCU to study its properties and role in mitochondrial signaling.".
- Mitochondrial_calcium_uniporter arm "22".
- Mitochondrial_calcium_uniporter band "2".
- Mitochondrial_calcium_uniporter chromosome "10".
- Mitochondrial_calcium_uniporter entrezgene "90550".
- Mitochondrial_calcium_uniporter hgncid "23526".
- Mitochondrial_calcium_uniporter omim "614197".
- Mitochondrial_calcium_uniporter pdb "Q8NE86".
- Mitochondrial_calcium_uniporter refseq "NM_138357".
- Mitochondrial_calcium_uniporter symbol "C10orf42, CCDC109A, FLJ46135".
- Mitochondrial_calcium_uniporter symbol "MCU".
- Mitochondrial_calcium_uniporter uniprot "Q8NE86".
- Mitochondrial_calcium_uniporter wikiPageID "49534415".
- Mitochondrial_calcium_uniporter wikiPageLength "4204".
- Mitochondrial_calcium_uniporter wikiPageOutDegree "19".
- Mitochondrial_calcium_uniporter wikiPageRevisionID "707955521".
- Mitochondrial_calcium_uniporter wikiPageWikiLink CBARA1.
- Mitochondrial_calcium_uniporter wikiPageWikiLink Calcium.
- Mitochondrial_calcium_uniporter wikiPageWikiLink Calcium_signaling.
- Mitochondrial_calcium_uniporter wikiPageWikiLink Category:Calcium_signaling.
- Mitochondrial_calcium_uniporter wikiPageWikiLink Category:Mitochondria.
- Mitochondrial_calcium_uniporter wikiPageWikiLink Category:Transmembrane_transporters.
- Mitochondrial_calcium_uniporter wikiPageWikiLink Cytosol.
- Mitochondrial_calcium_uniporter wikiPageWikiLink Endoplasmic_reticulum.
- Mitochondrial_calcium_uniporter wikiPageWikiLink Inner_mitochondrial_membrane.
- Mitochondrial_calcium_uniporter wikiPageWikiLink Inositol_trisphosphate.
- Mitochondrial_calcium_uniporter wikiPageWikiLink Ion.
- Mitochondrial_calcium_uniporter wikiPageWikiLink Ligand_(biochemistry).
- Mitochondrial_calcium_uniporter wikiPageWikiLink MICU2.
- Mitochondrial_calcium_uniporter wikiPageWikiLink Membrane_potential.
- Mitochondrial_calcium_uniporter wikiPageWikiLink Mitochondrion.
- Mitochondrial_calcium_uniporter wikiPageWikiLink Ru360.
- Mitochondrial_calcium_uniporter wikiPageWikiLink Ruthenium_red.
- Mitochondrial_calcium_uniporter wikiPageWikiLink Sodium-calcium_exchanger.
- Mitochondrial_calcium_uniporter wikiPageWikiLink Transmembrane_protein.
- Mitochondrial_calcium_uniporter wikiPageWikiLinkText "Mitochondrial Calcium Uniporter".
- Mitochondrial_calcium_uniporter wikiPageWikiLinkText "Mitochondrial calcium uniporter".
- Mitochondrial_calcium_uniporter wikiPageWikiLinkText "mitochondrial calcium uniporter".
- Mitochondrial_calcium_uniporter altsymbols "C10orf42, CCDC109A, FLJ46135".
- Mitochondrial_calcium_uniporter arm "22".
- Mitochondrial_calcium_uniporter band "2".
- Mitochondrial_calcium_uniporter chromosome "10".
- Mitochondrial_calcium_uniporter entrezgene "90550".
- Mitochondrial_calcium_uniporter hgncid "23526".
- Mitochondrial_calcium_uniporter name "Mitochondrial calcium uniporter".
- Mitochondrial_calcium_uniporter omim "614197".
- Mitochondrial_calcium_uniporter pdb "Q8NE86".
- Mitochondrial_calcium_uniporter refseq "NM_138357".
- Mitochondrial_calcium_uniporter symbol "MCU".
- Mitochondrial_calcium_uniporter uniprot "Q8NE86".
- Mitochondrial_calcium_uniporter wikiPageUsesTemplate Template:Infobox_protein.
- Mitochondrial_calcium_uniporter wikiPageUsesTemplate Template:Reflist.
- Mitochondrial_calcium_uniporter subject Category:Calcium_signaling.
- Mitochondrial_calcium_uniporter subject Category:Mitochondria.
- Mitochondrial_calcium_uniporter subject Category:Transmembrane_transporters.
- Mitochondrial_calcium_uniporter hypernym Protein.
- Mitochondrial_calcium_uniporter type Biomolecule.
- Mitochondrial_calcium_uniporter type Protein.
- Mitochondrial_calcium_uniporter type Thing.
- Mitochondrial_calcium_uniporter type Q206229.
- Mitochondrial_calcium_uniporter type Q8054.
- Mitochondrial_calcium_uniporter comment "The mitochondrial calcium uniporter (MCU) is a transmembrane protein that allows the passage of calcium ions from a cell's cytosol into mitochondria.".
- Mitochondrial_calcium_uniporter label "Mitochondrial calcium uniporter".
- Mitochondrial_calcium_uniporter wasDerivedFrom Mitochondrial_calcium_uniporter?oldid=707955521.
- Mitochondrial_calcium_uniporter isPrimaryTopicOf Mitochondrial_calcium_uniporter.