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- Mitochondrial_biogenesis abstract "Mitochondrial biogenesis is the process by which new mitochondria are formed in the cell. Mitochondrial biogenesis is activated by numerous different signals during times of cellular stress or in response to environmental stimuli. The mitochondrion is a key regulator of the metabolic activity of the cell, and is also an important organelle in both production and degradation of free radicals. It is reckoned that higher mitochodrial copy number (or higher mitochondrial mass) is protective for the cell.Mitochondria are produced from the transcription and translation of genes both in the nuclear genome and in the mitochondrial genome. The majority of mitochondrial protein comes from the nuclear genome, while the mitochondrial genome encodes most parts of the electron transport chain along with mitochondrial rRNA and tRNA. A major adaptation to mitochondrial biogenesis results in more mitochondrial tissues which increases metabolic enzymes for glycolysis, oxidative phosphorylation and ultimately a greater mitochondrial metabolic capacity.[Peter D. Wagner Summer 2011 Lecture]The master regulators of mitochondrial biogenesis appear to be the peroxisome proliferator-activated receptor gamma (PGC) family of transcriptional coactivators, including PGC-1α, PGC-1β, and the PGC-related coactivator, PRC. PGC-1α, in particular, is thought to be a master regulator. It is known to co-activate nuclear respiratory factor 2 (NRF2/GABPA), and together with NRF-2 coactivates nuclear respiratory factor 1 (NRF1). The NRFs, in turn, activate the mitochondrial transcription factor A (tfam), which is directly responsible for transcribing nuclear-encoded mitochondrial proteins. This includes both structural mitochondrial proteins as well as those involved in mtDNA transcription, translation, and repair.".
- Mitochondrial_biogenesis wikiPageID "22120746".
- Mitochondrial_biogenesis wikiPageLength "2155".
- Mitochondrial_biogenesis wikiPageOutDegree "13".
- Mitochondrial_biogenesis wikiPageRevisionID "703870584".
- Mitochondrial_biogenesis wikiPageWikiLink Category:Cell_biology.
- Mitochondrial_biogenesis wikiPageWikiLink Electron_transport_chain.
- Mitochondrial_biogenesis wikiPageWikiLink GABPA.
- Mitochondrial_biogenesis wikiPageWikiLink Human_mitochondrial_genetics.
- Mitochondrial_biogenesis wikiPageWikiLink Master_regulator.
- Mitochondrial_biogenesis wikiPageWikiLink Mitochondrial_DNA.
- Mitochondrial_biogenesis wikiPageWikiLink Mitochondrion.
- Mitochondrial_biogenesis wikiPageWikiLink NRF1.
- Mitochondrial_biogenesis wikiPageWikiLink PPARGC1A.
- Mitochondrial_biogenesis wikiPageWikiLink PPARGC1B.
- Mitochondrial_biogenesis wikiPageWikiLink Ribosomal_RNA.
- Mitochondrial_biogenesis wikiPageWikiLink TFAM.
- Mitochondrial_biogenesis wikiPageWikiLink Transfer_RNA.
- Mitochondrial_biogenesis wikiPageWikiLinkText "Mitochondrial biogenesis".
- Mitochondrial_biogenesis wikiPageWikiLinkText "mitochondrial biogenesis".
- Mitochondrial_biogenesis wikiPageUsesTemplate Template:Biology-stub.
- Mitochondrial_biogenesis wikiPageUsesTemplate Template:Cn.
- Mitochondrial_biogenesis wikiPageUsesTemplate Template:Medref.
- Mitochondrial_biogenesis wikiPageUsesTemplate Template:Reflist.
- Mitochondrial_biogenesis wikiPageUsesTemplate Template:Unreferenced.
- Mitochondrial_biogenesis subject Category:Cell_biology.
- Mitochondrial_biogenesis hypernym Process.
- Mitochondrial_biogenesis type Election.
- Mitochondrial_biogenesis type Discipline.
- Mitochondrial_biogenesis comment "Mitochondrial biogenesis is the process by which new mitochondria are formed in the cell. Mitochondrial biogenesis is activated by numerous different signals during times of cellular stress or in response to environmental stimuli. The mitochondrion is a key regulator of the metabolic activity of the cell, and is also an important organelle in both production and degradation of free radicals.".
- Mitochondrial_biogenesis label "Mitochondrial biogenesis".
- Mitochondrial_biogenesis sameAs Q6881848.
- Mitochondrial_biogenesis sameAs m.05p9_yg.
- Mitochondrial_biogenesis sameAs Q6881848.
- Mitochondrial_biogenesis wasDerivedFrom Mitochondrial_biogenesis?oldid=703870584.
- Mitochondrial_biogenesis isPrimaryTopicOf Mitochondrial_biogenesis.