Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Mir-375> ?p ?o }
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- Mir-375 abstract "In molecular biology miR-375 microRNA is a short RNA molecule. MicroRNAs (miRNAs) are small (18-25 nucleotides), non-coding RNAs that regulate genes post-transcriptionally by inhibiting translation and/or causing mRNA degradation. miR-375 is found on human chromosome 2 in between the CRYBA2 and CCDC108 genes.miR-375 is specifically expressed in the pancreatic islets and brain. miR-375 was one of the first miRNAs identified in the pancreas (Poy et al, 2004), and remains one of the best characterised in terms of function. It is expressed in the pancreas and pituitary gland, organs linked by their role in hormone secretion, and expression levels increase during pancreas organogenesis. Loss-of-function studies showed that miR-375 is essential for β-cell formation in zebrafish (Kloosterman et al, 2007). miR-375 knockout mice have decreased numbers of β-cells and increased numbers of α-cells. The increase in glucagon levels, combined with the reduction in insulin levels, results in hyperglycaemia. This shows the importance of miR-375 in the establishment of normal pancreatic cell mass through the targeting of a group of genes which control cellular growth and proliferation in the developing pancreas (Poy et al, 2009). Further evidence for the involvement of miR-375 in pancreas development includes the fact that its expression is regulated by several transcription factors important in pancreatic development and function, including HNF6, INSM1, NGN3, NEUROD1, and PDX-1 (Keller et al, 2007).".
- Mir-375 thumbnail RF00700.png?width=300.
- Mir-375 wikiPageID "29446465".
- Mir-375 wikiPageLength "7685".
- Mir-375 wikiPageOutDegree "22".
- Mir-375 wikiPageRevisionID "619668303".
- Mir-375 wikiPageWikiLink Brain.
- Mir-375 wikiPageWikiLink Breast_cancer.
- Mir-375 wikiPageWikiLink CCDC108.
- Mir-375 wikiPageWikiLink CRYBA2.
- Mir-375 wikiPageWikiLink Category:MicroRNA.
- Mir-375 wikiPageWikiLink Category:Non-coding_RNA.
- Mir-375 wikiPageWikiLink Chromosome_2_(human).
- Mir-375 wikiPageWikiLink Eukaryote.
- Mir-375 wikiPageWikiLink Exocytosis.
- Mir-375 wikiPageWikiLink Fluorescence_in_situ_hybridization.
- Mir-375 wikiPageWikiLink Gene_expression.
- Mir-375 wikiPageWikiLink Hormone.
- Mir-375 wikiPageWikiLink MTPN.
- Mir-375 wikiPageWikiLink Merkel-cell_carcinoma.
- Mir-375 wikiPageWikiLink Merkel_cell_polyomavirus.
- Mir-375 wikiPageWikiLink MicroRNA.
- Mir-375 wikiPageWikiLink Non-coding_RNA.
- Mir-375 wikiPageWikiLink Pancreatic_islets.
- Mir-375 wikiPageWikiLink Pyruvate_dehydrogenase_lipoamide_kinase_isozyme_1.
- Mir-375 wikiPageWikiLink Stomach_cancer.
- Mir-375 wikiPageWikiLink Three_prime_untranslated_region.
- Mir-375 wikiPageWikiLinkText "Mir-375".
- Mir-375 wikiPageWikiLinkText "mir-375".
- Mir-375 caption "Conserved secondary structure of mir-375".
- Mir-375 id "RF00700".
- Mir-375 mirbaseFamily "MIPF0000114".
- Mir-375 name "mir-375 microRNA precursor family".
- Mir-375 name "mir-375".
- Mir-375 rfam "RF00700".
- Mir-375 rnaType MicroRNA.
- Mir-375 symbol "mir-375".
- Mir-375 taxDomain "Eukaryota;".
- Mir-375 wikiPageUsesTemplate Template:Genetics-stub.
- Mir-375 wikiPageUsesTemplate Template:Infobox_rfam.
- Mir-375 wikiPageUsesTemplate Template:Reflist.
- Mir-375 wikiPageUsesTemplate Template:Rfam.
- Mir-375 subject Category:MicroRNA.
- Mir-375 subject Category:Non-coding_RNA.
- Mir-375 hypernym Molecule.
- Mir-375 type ChemicalCompound.
- Mir-375 type Redirect.
- Mir-375 comment "In molecular biology miR-375 microRNA is a short RNA molecule. MicroRNAs (miRNAs) are small (18-25 nucleotides), non-coding RNAs that regulate genes post-transcriptionally by inhibiting translation and/or causing mRNA degradation. miR-375 is found on human chromosome 2 in between the CRYBA2 and CCDC108 genes.miR-375 is specifically expressed in the pancreatic islets and brain.".
- Mir-375 label "Mir-375".
- Mir-375 sameAs Q6871782.
- Mir-375 sameAs m.0ds77_p.
- Mir-375 sameAs Q6871782.
- Mir-375 wasDerivedFrom Mir-375?oldid=619668303.
- Mir-375 depiction RF00700.png.
- Mir-375 isPrimaryTopicOf Mir-375.