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- Minimotif_Miner abstract "Minimotif Miner is a program and database designed to identify minimotifs in any protein. Minimotifs are short contiguous peptide sequences that are known to have a function in at least one protein. Minimotifs are also called sequence motifs or short linear motifs or SLiMs. These are generally restricted to one secondary structure element and are less than 15 amino acids in length. Functions can be binding motifs that bind another macromolecule or small compound, that induce a covalent modification of minimotif, or are involved in protein trafficking of the protein containing the minimotif. The basic premise of Minimotif Miner is that is a short peptide sequence is known to have a function in one protein, may have a similar function in another query protein. The current release of the MnM 3.0 database has ~300,000 minimotifs and can be searched at the website.There are two workflows that are of interest to scientists that use Minimotif Miner 1) Entering any query protein into Minimotif Miner returns a table with a list of minimotif sequence and functions that have a sequence pattern match with the protein query sequence. These provide potential new functions in the protein query. 2) By using the view single nucleotide polymorphism (SNP) function, SNPs from dbSNP are mapped in the sequence window. A user can select any set of the SNPs and then identify any minimotif that is introduced or eliminated by the SNP or mutation. This helps to identify minimotifs involved in generating organism diversity or those that may be associated with a disease.Typical results of MnM predict more than 50 new minimotifs for a protein query. A major limitation in this type of analysis is that the low sequence complexity of short minimotifs produces false positive predictions where the sequence occurs in a protein by random chance and not because it contains the predicted function. MnM 3.0 introduces a library of advanced heuristics and filters, which enable vast reduction of false positive predictions. These filters use minimotif complexity, protein surface location, molecular processes, cellular processes, protein-protein interactions, and genetic interactions. We recently combined all of these heuristics into a single, compound filter which makes significant progress toward solving this problem with high accuracy of minimotif prediction as measured by a performance benchmarking study which evaluated both sensitivity and specificity.".
- Minimotif_Miner thumbnail Database.png?width=300.
- Minimotif_Miner title "Minimotif Miner".
- Minimotif_Miner wikiPageExternalLink bio-toolkit.com.
- Minimotif_Miner wikiPageExternalLink minimotifminer.org.
- Minimotif_Miner wikiPageExternalLink mnm.engr.uconn.edu.
- Minimotif_Miner wikiPageExternalLink mnm.engr.uconn.edu.
- Minimotif_Miner wikiPageExternalLink www.minimotifminer.org.
- Minimotif_Miner wikiPageExternalLink mnm.
- Minimotif_Miner wikiPageID "27947144".
- Minimotif_Miner wikiPageLength "7724".
- Minimotif_Miner wikiPageOutDegree "9".
- Minimotif_Miner wikiPageRevisionID "706819567".
- Minimotif_Miner wikiPageWikiLink Category:Bioinformatics.
- Minimotif_Miner wikiPageWikiLink Category:Biological_databases.
- Minimotif_Miner wikiPageWikiLink Category:Molecular_biology.
- Minimotif_Miner wikiPageWikiLink Eukaryotic_Linear_Motif_resource.
- Minimotif_Miner wikiPageWikiLink Protein_targeting.
- Minimotif_Miner wikiPageWikiLink Sequence_motif.
- Minimotif_Miner wikiPageWikiLink Short_linear_motif.
- Minimotif_Miner wikiPageWikiLink Single-nucleotide_polymorphism.
- Minimotif_Miner wikiPageWikiLink File:Database.png.
- Minimotif_Miner wikiPageWikiLinkText "MiniMotif Miner".
- Minimotif_Miner wikiPageWikiLinkText "Minimotif Miner".
- Minimotif_Miner wikiPageWikiLinkText "Minimotif miner".
- Minimotif_Miner author "Mi, Tian; Merlin Jerlin Camilus, Deverasetty Sandeep, Gryk Michael R, Bill Travis J, Brooks Andrew W, Lee Logan Y, Rathnayake Viraj, Ross Christian A, Sargeant David P, Strong Christy L, Watts Paula, Rajasekaran Sanguthevar, Schiller Martin R".
- Minimotif_Miner description "database expansion and significantly improved reduction of false-positive predictions from consensus sequences.".
- Minimotif_Miner laboratory "Sanguthevar Rajasekaran and Martin R. Schiller".
- Minimotif_Miner logo File:Database.png.
- Minimotif_Miner pmid "Mi, Tian; Merlin Jerlin Camilus, Deverasetty Sandeep, Gryk Michael R, Bill Travis J, Brooks Andrew W, Lee Logan Y, Rathnayake Viraj, Ross Christian A, Sargeant David P, Strong Christy L, Watts Paula, Rajasekaran Sanguthevar, Schiller Martin R".
- Minimotif_Miner released "2011".
- Minimotif_Miner title "Minimotif Miner".
- Minimotif_Miner url minimotifminer.org.
- Minimotif_Miner url mnm.engr.uconn.edu.
- Minimotif_Miner wikiPageUsesTemplate Template:Cite_journal.
- Minimotif_Miner wikiPageUsesTemplate Template:Infobox_biodatabase.
- Minimotif_Miner wikiPageUsesTemplate Template:Reflist.
- Minimotif_Miner wikiPageUsesTemplate Template:Sections.
- Minimotif_Miner description "database expansion and significantly improved reduction of false-positive predictions from consensus sequences.".
- Minimotif_Miner subject Category:Bioinformatics.
- Minimotif_Miner subject Category:Biological_databases.
- Minimotif_Miner subject Category:Molecular_biology.
- Minimotif_Miner hypernym Program.
- Minimotif_Miner type BiologicalDatabase.
- Minimotif_Miner type Database.
- Minimotif_Miner type Work.
- Minimotif_Miner type Biostatistic.
- Minimotif_Miner type CreativeWork.
- Minimotif_Miner type InformationObject.
- Minimotif_Miner type Thing.
- Minimotif_Miner type Q386724.
- Minimotif_Miner comment "Minimotif Miner is a program and database designed to identify minimotifs in any protein. Minimotifs are short contiguous peptide sequences that are known to have a function in at least one protein. Minimotifs are also called sequence motifs or short linear motifs or SLiMs. These are generally restricted to one secondary structure element and are less than 15 amino acids in length.".
- Minimotif_Miner label "Minimotif Miner".
- Minimotif_Miner sameAs Q6865403.
- Minimotif_Miner sameAs m.0czd01d.
- Minimotif_Miner sameAs Q6865403.
- Minimotif_Miner wasDerivedFrom Minimotif_Miner?oldid=706819567.
- Minimotif_Miner depiction Database.png.
- Minimotif_Miner homepage mnm.engr.uconn.edu.
- Minimotif_Miner isPrimaryTopicOf Minimotif_Miner.