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- Microhomology-mediated_end_joining abstract "Microhomology-mediated end joining (MMEJ), also known as alternative nonhomologous end-joining (Alt-NHEJ) is one of the pathways for repairing double-strand breaks in DNA. As reviewed by McVey and Lee, the foremost distinguishing property of MMEJ is the use of 5–25 base pair (bp) microhomologous sequences during the alignment of broken ends before joining, thereby resulting in deletions flanking the original break. Thus, MMEJ is frequently associated with chromosome abnormalities such as deletions, translocations, inversions and other complex rearrangements.Two other well-known means of double-strand breakage repair are non-homologous end joining and homologous recombination. MMEJ is distinguished from the other repair mechanisms by its use of 5–25 base pair microhomologous sequences to align the broken strands before joining. MMEJ uses a Ku protein and DNA-PK independent repair mechanism, and repair occurs during the S-phase of the cell cycle, as opposed to the G0/G1 and early S-phases in NHEJ and late S to G2-phase in HR.MMEJ works by ligating the mismatched hanging strands of DNA, removing overhanging nucleotides, and filling in the missing base pairs. When a break occurs, a homology of 5 - 25 complementary base pairs on both strands is identified and used as a basis for which to align the strands with mismatched ends. Once aligned, any overhanging bases (flaps) and mismatched bases on the strands are removed and any missing nucleotides are inserted. As this method's only way of identifying if the two strands are related is based on microhomology down/upstream from the site of breakage, it does not identify any missing base pairs which may have been lost during the break, and even removes nucleotides (flaps) in order to ligate the strand. MMEJ ligates the DNA strands without checking for consistency and causes deletions, since it removes base pairs (flaps) in order to align the two pieces.MMEJ is an error-prone method of repair and results in deletion mutations in the genetic code, which may initiate the creation of oncogenes that could lead to the development of cancer. In most cases a cell uses MMEJ only when the NHEJ method is unavailable or unsuitable, due to the disadvantage posed by introducing deletions into the genetic code.".
- Microhomology-mediated_end_joining wikiPageExternalLink j.mrfmmm.2007.08.016.
- Microhomology-mediated_end_joining wikiPageExternalLink 5249.
- Microhomology-mediated_end_joining wikiPageExternalLink S0168-9525(08)00229-1.
- Microhomology-mediated_end_joining wikiPageID "23185466".
- Microhomology-mediated_end_joining wikiPageLength "15811".
- Microhomology-mediated_end_joining wikiPageOutDegree "29".
- Microhomology-mediated_end_joining wikiPageRevisionID "701746049".
- Microhomology-mediated_end_joining wikiPageWikiLink Cancer_syndrome.
- Microhomology-mediated_end_joining wikiPageWikiLink Category:DNA_repair.
- Microhomology-mediated_end_joining wikiPageWikiLink DNA-PKcs.
- Microhomology-mediated_end_joining wikiPageWikiLink DNA_repair.
- Microhomology-mediated_end_joining wikiPageWikiLink DNA_repair-deficiency_disorder.
- Microhomology-mediated_end_joining wikiPageWikiLink Flap_structure-specific_endonuclease_1.
- Microhomology-mediated_end_joining wikiPageWikiLink Homologous_recombination.
- Microhomology-mediated_end_joining wikiPageWikiLink Ku_(protein).
- Microhomology-mediated_end_joining wikiPageWikiLink LIG3.
- Microhomology-mediated_end_joining wikiPageWikiLink MRE11A.
- Microhomology-mediated_end_joining wikiPageWikiLink Nibrin.
- Microhomology-mediated_end_joining wikiPageWikiLink Non-homologous_end_joining.
- Microhomology-mediated_end_joining wikiPageWikiLink Non-small-cell_lung_carcinoma.
- Microhomology-mediated_end_joining wikiPageWikiLink Oncogene.
- Microhomology-mediated_end_joining wikiPageWikiLink PARP1.
- Microhomology-mediated_end_joining wikiPageWikiLink S_phase.
- Microhomology-mediated_end_joining wikiPageWikiLink XRCC1.
- Microhomology-mediated_end_joining wikiPageWikiLink Zygosity.
- Microhomology-mediated_end_joining wikiPageWikiLinkText "MMEJ".
- Microhomology-mediated_end_joining wikiPageWikiLinkText "Microhomology-mediated end joining".
- Microhomology-mediated_end_joining wikiPageWikiLinkText "microhomology mediated break induced replication".
- Microhomology-mediated_end_joining wikiPageWikiLinkText "microhomology-mediated break induced repair".
- Microhomology-mediated_end_joining wikiPageWikiLinkText "microhomology-mediated end joining".
- Microhomology-mediated_end_joining wikiPageUsesTemplate Template:DNA_repair.
- Microhomology-mediated_end_joining wikiPageUsesTemplate Template:More_footnotes.
- Microhomology-mediated_end_joining wikiPageUsesTemplate Template:Reflist.
- Microhomology-mediated_end_joining subject Category:DNA_repair.
- Microhomology-mediated_end_joining hypernym Pathways.
- Microhomology-mediated_end_joining type Process.
- Microhomology-mediated_end_joining type Redirect.
- Microhomology-mediated_end_joining comment "Microhomology-mediated end joining (MMEJ), also known as alternative nonhomologous end-joining (Alt-NHEJ) is one of the pathways for repairing double-strand breaks in DNA. As reviewed by McVey and Lee, the foremost distinguishing property of MMEJ is the use of 5–25 base pair (bp) microhomologous sequences during the alignment of broken ends before joining, thereby resulting in deletions flanking the original break.".
- Microhomology-mediated_end_joining label "Microhomology-mediated end joining".
- Microhomology-mediated_end_joining sameAs Q2066027.
- Microhomology-mediated_end_joining sameAs m.064n678.
- Microhomology-mediated_end_joining sameAs Q2066027.
- Microhomology-mediated_end_joining wasDerivedFrom Microhomology-mediated_end_joining?oldid=701746049.
- Microhomology-mediated_end_joining isPrimaryTopicOf Microhomology-mediated_end_joining.