Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/MicroRNA> ?p ?o }
- MicroRNA abstract "A micro RNA (abbreviated miRNA) is a small non-coding RNA molecule (containing about 22 nucleotides) found in plants, animals and some viruses, that functions in RNA silencing and post-transcriptional regulation of gene expression.Encoded by eukaryotic nuclear DNA in plants and animals and by viral DNA in certain viruses whose genome is based on DNA, miRNAs function via base-pairing with complementary sequences within mRNA molecules. As a result, these mRNA molecules are silenced, by one or more of the following processes: Cleavage of the mRNA strand into two pieces, Destabilization of the mRNA through shortening of its poly(A) tail, and Less efficient translation of the mRNA into proteins by ribosomes. miRNAs resemble the small interfering RNAs (siRNAs) of the RNA interference (RNAi) pathway, except miRNAs derive from regions of RNA transcripts that fold back on themselves to form short hairpins, whereas siRNAs derive from longer regions of double-stranded RNA. The human genome may encode over 1000 miRNAs, which are abundant in many mammalian cell types and appear to target about 60% of the genes of humans and other mammals.miRNAs are well conserved in both plants and animals, and are thought to be a vital and evolutionarily ancient component of gene regulation. While core components of the microRNA pathway are conserved between plants and animals, miRNA repertoires in the two kingdoms appear to have emerged independently with different primary modes of action.Plant miRNAs usually have near-perfect pairing with their mRNA targets, which induces gene repression through cleavage of the target transcripts. In contrast, animal miRNAs are able to recognize their target mRNAs by using as little as 6–8 nucleotides (the seed region) at the 5' end of the miRNA, which is not enough pairing to induce cleavage of the target mRNAs. Combinatorial regulation is a feature of miRNA regulation in animals. A given miRNA may have hundreds of different mRNA targets, and a given target might be regulated by multiple miRNAs.The first miRNA was discovered in the early 1990s. However, miRNAs were not recognized as a distinct class of biological regulators until the early 2000s. miRNA research revealed different sets of miRNAs expressed in different cell types and tissues and multiple roles for miRNAs in plant and animal development and in many other biological processes. Aberrant miRNA expression are implicated in disease states. MiRNA-based therapies are under investigation.Estimates of the average number of unique messenger RNAs that are targets for repression by a typical miRNA vary, depending on the estimation method, but multiple approaches show that mammalian miRNAs can have many unique targets. For example, an analysis of the miRNAs highly conserved in vertebrates shows that each has, on average, roughly 400 conserved targets. Likewise, experiments show that a single miRNA can reduce the stability of hundreds of unique messenger RNAs. Other experiments show that a single miRNA may repress the production of hundreds of proteins, but that this repression often is relatively mild (less than 2-fold). The first human disease associated with deregulation of miRNAs was chronic lymphocytic leukemia. Other B cell malignancies followed.".
- MicroRNA thumbnail MiRNA.svg?width=300.
- MicroRNA wikiPageExternalLink www.mirbase.org.
- MicroRNA wikiPageExternalLink mirob.interactome.ru.
- MicroRNA wikiPageExternalLink semirna.
- MicroRNA wikiPageExternalLink www.miR2Disease.org.
- MicroRNA wikiPageExternalLink watch?v=_-9pROnSD-A.
- MicroRNA wikiPageID "156964".
- MicroRNA wikiPageLength "138759".
- MicroRNA wikiPageOutDegree "274".
- MicroRNA wikiPageRevisionID "707288728".
- MicroRNA wikiPageWikiLink 5-3_exoribonuclease_2.
- MicroRNA wikiPageWikiLink ARID3A.
- MicroRNA wikiPageWikiLink AT-hook.
- MicroRNA wikiPageWikiLink Addiction.
- MicroRNA wikiPageWikiLink Adenosine.
- MicroRNA wikiPageWikiLink Adenosine_deaminase.
- MicroRNA wikiPageWikiLink Adenosine_monophosphate.
- MicroRNA wikiPageWikiLink Adipocyte.
- MicroRNA wikiPageWikiLink Adipogenesis.
- MicroRNA wikiPageWikiLink Ageing.
- MicroRNA wikiPageWikiLink Alcohol_withdrawal_syndrome.
- MicroRNA wikiPageWikiLink Alcoholism.
- MicroRNA wikiPageWikiLink Alu_element.
- MicroRNA wikiPageWikiLink Animal.
- MicroRNA wikiPageWikiLink Antagomir.
- MicroRNA wikiPageWikiLink Anti-miRNA_oligonucleotides.
- MicroRNA wikiPageWikiLink Anxiety_disorder.
- MicroRNA wikiPageWikiLink Apoptosis.
- MicroRNA wikiPageWikiLink Arabidopsis_thaliana.
- MicroRNA wikiPageWikiLink Argonaute.
- MicroRNA wikiPageWikiLink Arteriole.
- MicroRNA wikiPageWikiLink Arthropod.
- MicroRNA wikiPageWikiLink Atherosclerosis.
- MicroRNA wikiPageWikiLink B-cell_chronic_lymphocytic_leukemia.
- MicroRNA wikiPageWikiLink B-cell_receptor.
- MicroRNA wikiPageWikiLink BCL2-like_1_(gene).
- MicroRNA wikiPageWikiLink Basal_forebrain.
- MicroRNA wikiPageWikiLink Base_pair.
- MicroRNA wikiPageWikiLink Bcl-2-associated_X_protein.
- MicroRNA wikiPageWikiLink Bipolar_disorder.
- MicroRNA wikiPageWikiLink Blood_plasma.
- MicroRNA wikiPageWikiLink Bone_marrow.
- MicroRNA wikiPageWikiLink Brain-derived_neurotrophic_factor.
- MicroRNA wikiPageWikiLink Brown_algae.
- MicroRNA wikiPageWikiLink CEBPA.
- MicroRNA wikiPageWikiLink CT_scan.
- MicroRNA wikiPageWikiLink Caenorhabditis_elegans.
- MicroRNA wikiPageWikiLink Cancer.
- MicroRNA wikiPageWikiLink Cardiomyopathy.
- MicroRNA wikiPageWikiLink Category:Articles_with_inconsistent_citation_formats.
- MicroRNA wikiPageWikiLink Category:Gene_expression.
- MicroRNA wikiPageWikiLink Category:MicroRNA.
- MicroRNA wikiPageWikiLink Category:RNA.
- MicroRNA wikiPageWikiLink Causality.
- MicroRNA wikiPageWikiLink Cell_adhesion.
- MicroRNA wikiPageWikiLink Cell_cycle.
- MicroRNA wikiPageWikiLink Cell_growth.
- MicroRNA wikiPageWikiLink Cell_nucleus.
- MicroRNA wikiPageWikiLink Cell_potency.
- MicroRNA wikiPageWikiLink Cell_signaling.
- MicroRNA wikiPageWikiLink Chromatin.
- MicroRNA wikiPageWikiLink Chromosome.
- MicroRNA wikiPageWikiLink Cistron.
- MicroRNA wikiPageWikiLink Collagen.
- MicroRNA wikiPageWikiLink Colorectal_cancer.
- MicroRNA wikiPageWikiLink Competing_endogenous_RNA_(CeRNA).
- MicroRNA wikiPageWikiLink Complementarity_(molecular_biology).
- MicroRNA wikiPageWikiLink Complementary_DNA.
- MicroRNA wikiPageWikiLink Conserved_sequence.
- MicroRNA wikiPageWikiLink CpG_site.
- MicroRNA wikiPageWikiLink Cytokine.
- MicroRNA wikiPageWikiLink Cytoplasm.
- MicroRNA wikiPageWikiLink DCL1.
- MicroRNA wikiPageWikiLink DGCR8.
- MicroRNA wikiPageWikiLink DNA_methylation.
- MicroRNA wikiPageWikiLink DNA_mismatch_repair.
- MicroRNA wikiPageWikiLink DNA_repair.
- MicroRNA wikiPageWikiLink DNA_replication.
- MicroRNA wikiPageWikiLink Decision-making.
- MicroRNA wikiPageWikiLink Dendrimer.
- MicroRNA wikiPageWikiLink Dextran.
- MicroRNA wikiPageWikiLink DiGeorge_syndrome.
- MicroRNA wikiPageWikiLink Diabetes_mellitus.
- MicroRNA wikiPageWikiLink Dicer.
- MicroRNA wikiPageWikiLink Dopamine_receptor_D1.
- MicroRNA wikiPageWikiLink Drosha.
- MicroRNA wikiPageWikiLink Drosophila.
- MicroRNA wikiPageWikiLink E2F1.
- MicroRNA wikiPageWikiLink ERCC1.
- MicroRNA wikiPageWikiLink Ectopic_expression.
- MicroRNA wikiPageWikiLink Elastin.
- MicroRNA wikiPageWikiLink Enzyme.
- MicroRNA wikiPageWikiLink Epigenetics.
- MicroRNA wikiPageWikiLink Eukaryote.
- MicroRNA wikiPageWikiLink Eukaryotic_translation.
- MicroRNA wikiPageWikiLink Exon.
- MicroRNA wikiPageWikiLink Exoribonuclease.
- MicroRNA wikiPageWikiLink FOSB.
- MicroRNA wikiPageWikiLink Feed_forward_(control).