Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Metofoline> ?p ?o }
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- Metofoline abstract "Methopholine is an opioid analgesic drug discovered in the 1950s by a team of Swiss researchers at Hoffmann-La Roche.Methopholine is an isoquinoline derivative which is not structurally related to most other opioids.However, its structural similarity to papaverine is notable.It has around the same efficacy as an analgesic as codeine, and was evaluated for the treatment of postoperative pain. Methopholine tablets were marketed in the United States under the brand name of Versidyne, but the drug was withdrawn from the market in 1965 due to the occurrence of ophthalmic side-effects and the discovery that it could produce corneal opacities in dogs.Methopholine has two enantiomers, with the levo (R) enantiomer being the active form, around 3x the potency of codeine, and the (S) enantiomer being inactive.Analogues where the 4'-chloro group has been replaced by other groups have also been tested, the fluoro derivative being slightly more potent than chloro, and the nitro derivative being most potent of all, with the racemic 4'-nitromethopholine being around 20x the potency of codeine.".
- Metofoline atcPrefix "none".
- Metofoline casNumber "2154-02-1".
- Metofoline casSupplemental "63937-57-5 (4'-nitromethopholine)".
- Metofoline fdaUniiCode "72L4ZT2W1P".
- Metofoline iupacName "1-[2-(4-chlorophenyl)ethyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline".
- Metofoline pubchem "16538".
- Metofoline thumbnail Methopholine.svg?width=300.
- Metofoline wikiPageID "13967330".
- Metofoline wikiPageLength "5807".
- Metofoline wikiPageOutDegree "14".
- Metofoline wikiPageRevisionID "679090468".
- Metofoline wikiPageWikiLink Analgesic.
- Metofoline wikiPageWikiLink Category:Abandoned_drugs.
- Metofoline wikiPageWikiLink Category:Chloroarenes.
- Metofoline wikiPageWikiLink Category:Mu-opioid_agonists.
- Metofoline wikiPageWikiLink Category:Phenol_ethers.
- Metofoline wikiPageWikiLink Category:Synthetic_opioids.
- Metofoline wikiPageWikiLink Category:Tetrahydroisoquinolines.
- Metofoline wikiPageWikiLink Codeine.
- Metofoline wikiPageWikiLink Enantiomer.
- Metofoline wikiPageWikiLink Human_eye.
- Metofoline wikiPageWikiLink Isoquinoline.
- Metofoline wikiPageWikiLink Opioid.
- Metofoline wikiPageWikiLink Papaverine.
- Metofoline wikiPageWikiLink File:4-nitromethopholine_structure.png.
- Metofoline wikiPageWikiLinkText "Metofoline".
- Metofoline wikiPageWikiLinkText "metofoline".
- Metofoline atcPrefix "none".
- Metofoline c "20".
- Metofoline casNumber "2154-02-01".
- Metofoline casSupplemental "63937".
- Metofoline chemspiderid "15678".
- Metofoline cl "1".
- Metofoline h "24".
- Metofoline inchi "1".
- Metofoline inchikey "YBCPYHQFUMNOJG-UHFFFAOYAD".
- Metofoline iupacName "1".
- Metofoline kegg "D04986".
- Metofoline legalStatus "Legal".
- Metofoline molecularWeight "345.87".
- Metofoline n "1".
- Metofoline o "2".
- Metofoline pubchem "16538".
- Metofoline smiles "ClC1=CC=CC=C1".
- Metofoline stdinchi "1".
- Metofoline stdinchikey "YBCPYHQFUMNOJG-UHFFFAOYSA-N".
- Metofoline unii "72".
- Metofoline verifiedrevid "450690409".
- Metofoline width "180".
- Metofoline wikiPageUsesTemplate Template:Cascite.
- Metofoline wikiPageUsesTemplate Template:Chemspidercite.
- Metofoline wikiPageUsesTemplate Template:Drugbankcite.
- Metofoline wikiPageUsesTemplate Template:Drugbox.
- Metofoline wikiPageUsesTemplate Template:Fdacite.
- Metofoline wikiPageUsesTemplate Template:Keggcite.
- Metofoline wikiPageUsesTemplate Template:Opioidergics.
- Metofoline wikiPageUsesTemplate Template:Reflist.
- Metofoline wikiPageUsesTemplate Template:Stdinchicite.
- Metofoline subject Category:Abandoned_drugs.
- Metofoline subject Category:Chloroarenes.
- Metofoline subject Category:Mu-opioid_agonists.
- Metofoline subject Category:Phenol_ethers.
- Metofoline subject Category:Synthetic_opioids.
- Metofoline subject Category:Tetrahydroisoquinolines.
- Metofoline hypernym Drug.
- Metofoline type ChemicalSubstance.
- Metofoline type Drug.
- Metofoline type Agonist.
- Metofoline type Drug.
- Metofoline type Ether.
- Metofoline type Heterocycle.
- Metofoline type Opioid.
- Metofoline type Organohalide.
- Metofoline type Organohalide.
- Metofoline type ChemicalObject.
- Metofoline type Thing.
- Metofoline type Q8386.
- Metofoline comment "Methopholine is an opioid analgesic drug discovered in the 1950s by a team of Swiss researchers at Hoffmann-La Roche.Methopholine is an isoquinoline derivative which is not structurally related to most other opioids.However, its structural similarity to papaverine is notable.It has around the same efficacy as an analgesic as codeine, and was evaluated for the treatment of postoperative pain.".
- Metofoline label "Metofoline".
- Metofoline sameAs Q6824210.
- Metofoline sameAs m.03cpn3m.
- Metofoline sameAs Metofolin.
- Metofoline sameAs Metofolin.
- Metofoline sameAs Q6824210.
- Metofoline wasDerivedFrom Metofoline?oldid=679090468.
- Metofoline depiction Methopholine.svg.
- Metofoline isPrimaryTopicOf Metofoline.