Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Methylphenidate> ?p ?o }
- Methylphenidate abstract "Methylphenidate, sold under various trade names, Ritalin being one of the most commonly known, is a central nervous system (CNS) stimulant of the phenethylamine and piperidine classes that is used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. The original patent was owned by CIBA, now Novartis Corporation. It was first licensed by the U.S. Food and Drug Administration (FDA) in 1955 for treating what was then known as hyperactivity.Medical use began in 1960; the drug has become increasingly prescribed since the 1990s, when the diagnosis of ADHD itself became more widely accepted. Between 2007 and 2012 methylphenidate prescriptions increased by 50% in the United Kingdom and in 2013 global methylphenidate consumption increased to 2.4 billion doses, a 66% increase from the year before. The United States continues to account for more than 80% of global consumption.ADHD and other similar conditions are believed to be linked to sub-performance of the dopamine and norepinephrine functions in the brain, primarily in the prefrontal cortex, responsible for executive function (e.g., reasoning, inhibiting behaviors, organizing, problem solving, planning, etc.). Methylphenidate's mechanism of action involves the inhibition of catecholamine reuptake, primarily as a dopamine reuptake inhibitor. Methylphenidate acts by blocking the dopamine transporter and norepinephrine transporter, leading to increased concentrations of dopamine and norepinephrine within the synaptic cleft. This effect in turn leads to increased neurotransmission of dopamine and norepinephrine. Methylphenidate is also a 5HT1A receptor agonist.".
- Methylphenidate thumbnail Methylphenidate-2D-skeletal.svg?width=300.
- Methylphenidate wikiPageExternalLink dpdirect.jsp?name=Methylphenidate.
- Methylphenidate wikiPageID "205878".
- Methylphenidate wikiPageLength "97923".
- Methylphenidate wikiPageOutDegree "348".
- Methylphenidate wikiPageRevisionID "706887123".
- Methylphenidate wikiPageWikiLink 2-Benzylpiperidine.
- Methylphenidate wikiPageWikiLink 3,4-Dichloromethylphenidate.
- Methylphenidate wikiPageWikiLink 4-Methylmethylphenidate.
- Methylphenidate wikiPageWikiLink 5-HT1A_receptor.
- Methylphenidate wikiPageWikiLink 5-HT2B_receptor.
- Methylphenidate wikiPageWikiLink Abdominal_pain.
- Methylphenidate wikiPageWikiLink Abscess.
- Methylphenidate wikiPageWikiLink Addiction.
- Methylphenidate wikiPageWikiLink Adrenergic_receptor.
- Methylphenidate wikiPageWikiLink Adrenergic_storm.
- Methylphenidate wikiPageWikiLink Adverse_effect.
- Methylphenidate wikiPageWikiLink Akathisia.
- Methylphenidate wikiPageWikiLink Alpha-2_adrenergic_receptor.
- Methylphenidate wikiPageWikiLink Alza.
- Methylphenidate wikiPageWikiLink Amphetamine.
- Methylphenidate wikiPageWikiLink Anger.
- Methylphenidate wikiPageWikiLink Angina_pectoris.
- Methylphenidate wikiPageWikiLink Anorexia_(symptom).
- Methylphenidate wikiPageWikiLink Anticonvulsant.
- Methylphenidate wikiPageWikiLink Antihypotensive_agent.
- Methylphenidate wikiPageWikiLink Antipsychotic.
- Methylphenidate wikiPageWikiLink Anxiety.
- Methylphenidate wikiPageWikiLink Attention_deficit_hyperactivity_disorder.
- Methylphenidate wikiPageWikiLink Australia.
- Methylphenidate wikiPageWikiLink Barbara_Sahakian.
- Methylphenidate wikiPageWikiLink Barbiturate.
- Methylphenidate wikiPageWikiLink Behavior_modification.
- Methylphenidate wikiPageWikiLink Benzodiazepine.
- Methylphenidate wikiPageWikiLink Beta-adrenergic_agonist.
- Methylphenidate wikiPageWikiLink Bioavailability.
- Methylphenidate wikiPageWikiLink Bipolar_disorder.
- Methylphenidate wikiPageWikiLink Blood_pressure.
- Methylphenidate wikiPageWikiLink Blurred_vision.
- Methylphenidate wikiPageWikiLink Bruxism.
- Methylphenidate wikiPageWikiLink Canada.
- Methylphenidate wikiPageWikiLink Capsule_(pharmacy).
- Methylphenidate wikiPageWikiLink Carboxylesterase_1.
- Methylphenidate wikiPageWikiLink Cardiac_arrhythmia.
- Methylphenidate wikiPageWikiLink Catecholamine.
- Methylphenidate wikiPageWikiLink Category:Amphetamine.
- Methylphenidate wikiPageWikiLink Category:Biology_of_bipolar_disorder.
- Methylphenidate wikiPageWikiLink Category:Carboxylate_esters.
- Methylphenidate wikiPageWikiLink Category:Euphoriants.
- Methylphenidate wikiPageWikiLink Category:Methyl_esters.
- Methylphenidate wikiPageWikiLink Category:Methylphenidate.
- Methylphenidate wikiPageWikiLink Category:Nootropics.
- Methylphenidate wikiPageWikiLink Category:Norepinephrine-dopamine_reuptake_inhibitors.
- Methylphenidate wikiPageWikiLink Category:Piperidines.
- Methylphenidate wikiPageWikiLink Category:Sigma_agonists.
- Methylphenidate wikiPageWikiLink Category:Stimulants.
- Methylphenidate wikiPageWikiLink Category:Sympathomimetic_amines.
- Methylphenidate wikiPageWikiLink Category:Treatment_and_management_of_attention_deficit_hyperactivity_disorder.
- Methylphenidate wikiPageWikiLink Category:Vasoconstrictors.
- Methylphenidate wikiPageWikiLink Central_nervous_system.
- Methylphenidate wikiPageWikiLink Charles_Bradley_(doctor).
- Methylphenidate wikiPageWikiLink Chemical_classification.
- Methylphenidate wikiPageWikiLink Chemical_synapse.
- Methylphenidate wikiPageWikiLink Chemical_synthesis.
- Methylphenidate wikiPageWikiLink Circulatory_collapse.
- Methylphenidate wikiPageWikiLink Clinical_trial.
- Methylphenidate wikiPageWikiLink Cocaethylene.
- Methylphenidate wikiPageWikiLink Cocaine.
- Methylphenidate wikiPageWikiLink Cognitive_behavioral_therapy.
- Methylphenidate wikiPageWikiLink Cognitive_inhibition.
- Methylphenidate wikiPageWikiLink Coma.
- Methylphenidate wikiPageWikiLink Confusion.
- Methylphenidate wikiPageWikiLink Controlled_Drugs_and_Substances_Act.
- Methylphenidate wikiPageWikiLink Controlled_Substances_Act.
- Methylphenidate wikiPageWikiLink Controlled_substance.
- Methylphenidate wikiPageWikiLink Convention_on_Psychotropic_Substances.
- Methylphenidate wikiPageWikiLink Convulsion.
- Methylphenidate wikiPageWikiLink D1-like_receptor.
- Methylphenidate wikiPageWikiLink Daytrana.
- Methylphenidate wikiPageWikiLink Delirium.
- Methylphenidate wikiPageWikiLink Depression_(mood).
- Methylphenidate wikiPageWikiLink Derivative.
- Methylphenidate wikiPageWikiLink Dexmethylphenidate.
- Methylphenidate wikiPageWikiLink Dextrorotation_and_levorotation.
- Methylphenidate wikiPageWikiLink Diastereomer.
- Methylphenidate wikiPageWikiLink Diplopia.
- Methylphenidate wikiPageWikiLink Dizziness.
- Methylphenidate wikiPageWikiLink Dopamine.
- Methylphenidate wikiPageWikiLink Dopamine_receptor_D1.
- Methylphenidate wikiPageWikiLink Dopamine_reuptake_inhibitor.
- Methylphenidate wikiPageWikiLink Dopamine_transporter.
- Methylphenidate wikiPageWikiLink Dopaminergic.
- Methylphenidate wikiPageWikiLink Dyskinesia.
- Methylphenidate wikiPageWikiLink Enantiomer.
- Methylphenidate wikiPageWikiLink Epimer.
- Methylphenidate wikiPageWikiLink Episodic_memory.
- Methylphenidate wikiPageWikiLink Ethanol.
- Methylphenidate wikiPageWikiLink Ethylphenidate.
- Methylphenidate wikiPageWikiLink Euphoria.