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- Methyl-CpG-binding_domain abstract "The Methyl-CpG-binding domain (MBD) in molecular biology binds to DNA that contains one or more symmetrically methylated CpGs. MBD has negligible non-specific affinity for unmethylated DNA. In vitro foot-printing with the chromosomal protein MeCP2 showed that the MBD could protect a 12 nucleotide region surrounding a methyl CpG pair.DNA methylation at CpG dinucleotides, the most common DNA modification in eukaryotes, has been associated with various phenomena such as alterations in chromatin structure, genomic imprinting, transposon and chromosome X inactivation, differentiation, and cancer. Effects of DNA methylation are mediated through proteins that bind to symmetrically methylated CpGs. Such proteins contain a specific domain of ~70 residues, the methyl-CpG-binding domain (MBD), which is linked to additional domains associated with chromatin, such as the bromodomain, the AT hook motif, the SET domain, or the PHD finger. MBD-containing proteins appear to act as structural proteins, which recruit a variety of histone deacetylase (HDAC) complexes and chromatin remodelling factors, leading to chromatin compaction and, consequently, to transcriptional repression. The MBD of MeCP2, MBD1, MBD2, MBD4 and BAZ2 mediates binding to DNA, and in cases of MeCP2, MBD1 and MBD2, preferentially to methylated CpG. In human MBD3 and SETDB1, the MBD has been shown to mediate protein-protein interactions. MBDs are also found in DNA demethylase.The MBD folds into an alpha/beta sandwich structure comprising a layer of twisted beta sheet, backed by another layer formed by the alpha1 helix and a hairpin loop at the C terminus. These layers are both amphipathic, with the alpha1 helix and the beta sheet lying parallel and the hydrophobic faces tightly packed against each other. The beta sheet is composed of two long inner strands (beta2 and beta3) sandwiched by two shorter outer strands (beta1 and beta4).".
- Methyl-CpG-binding_domain symbol "MBD".
- Methyl-CpG-binding_domain thumbnail PDB_1ub1_EBI.jpg?width=300.
- Methyl-CpG-binding_domain wikiPageID "32752159".
- Methyl-CpG-binding_domain wikiPageLength "4437".
- Methyl-CpG-binding_domain wikiPageOutDegree "42".
- Methyl-CpG-binding_domain wikiPageRevisionID "609107625".
- Methyl-CpG-binding_domain wikiPageWikiLink AT-hook.
- Methyl-CpG-binding_domain wikiPageWikiLink Amphiphile.
- Methyl-CpG-binding_domain wikiPageWikiLink BAZ2A.
- Methyl-CpG-binding_domain wikiPageWikiLink Beta_sheet.
- Methyl-CpG-binding_domain wikiPageWikiLink Biomolecular_structure.
- Methyl-CpG-binding_domain wikiPageWikiLink Bromodomain.
- Methyl-CpG-binding_domain wikiPageWikiLink Cancer.
- Methyl-CpG-binding_domain wikiPageWikiLink Category:Protein_domains.
- Methyl-CpG-binding_domain wikiPageWikiLink Chromatin.
- Methyl-CpG-binding_domain wikiPageWikiLink Chromosome.
- Methyl-CpG-binding_domain wikiPageWikiLink CpG_site.
- Methyl-CpG-binding_domain wikiPageWikiLink DNA.
- Methyl-CpG-binding_domain wikiPageWikiLink Demethylase.
- Methyl-CpG-binding_domain wikiPageWikiLink Domain_(biology).
- Methyl-CpG-binding_domain wikiPageWikiLink Genome.
- Methyl-CpG-binding_domain wikiPageWikiLink Helix.
- Methyl-CpG-binding_domain wikiPageWikiLink Histone_deacetylase.
- Methyl-CpG-binding_domain wikiPageWikiLink Homo_sapiens.
- Methyl-CpG-binding_domain wikiPageWikiLink Hydrophobe.
- Methyl-CpG-binding_domain wikiPageWikiLink MBD1.
- Methyl-CpG-binding_domain wikiPageWikiLink MBD3.
- Methyl-CpG-binding_domain wikiPageWikiLink MBD4.
- Methyl-CpG-binding_domain wikiPageWikiLink MECP2.
- Methyl-CpG-binding_domain wikiPageWikiLink Methyl-CpG-binding_domain_protein_2.
- Methyl-CpG-binding_domain wikiPageWikiLink Methylation.
- Methyl-CpG-binding_domain wikiPageWikiLink Molecular_binding.
- Methyl-CpG-binding_domain wikiPageWikiLink Molecular_biology.
- Methyl-CpG-binding_domain wikiPageWikiLink PHD_finger.
- Methyl-CpG-binding_domain wikiPageWikiLink Protein.
- Methyl-CpG-binding_domain wikiPageWikiLink Protein_domain.
- Methyl-CpG-binding_domain wikiPageWikiLink Protein_folding.
- Methyl-CpG-binding_domain wikiPageWikiLink Protein–protein_interaction.
- Methyl-CpG-binding_domain wikiPageWikiLink Repressor.
- Methyl-CpG-binding_domain wikiPageWikiLink SETDB1.
- Methyl-CpG-binding_domain wikiPageWikiLink SET_domain.
- Methyl-CpG-binding_domain wikiPageWikiLink Transcription_(genetics).
- Methyl-CpG-binding_domain wikiPageWikiLink Transposable_element.
- Methyl-CpG-binding_domain wikiPageWikiLink Turn_(biochemistry).
- Methyl-CpG-binding_domain wikiPageWikiLinkText "Methyl-CpG-binding domain".
- Methyl-CpG-binding_domain wikiPageWikiLinkText "methyl-CpG binding domain".
- Methyl-CpG-binding_domain wikiPageWikiLinkText "methyl-CpG-binding domain".
- Methyl-CpG-binding_domain caption "solution structure of the matrix attachment region-binding domain of chicken mecp2".
- Methyl-CpG-binding_domain cdd "cd00122".
- Methyl-CpG-binding_domain interpro "IPR001739".
- Methyl-CpG-binding_domain name "MBD".
- Methyl-CpG-binding_domain pfam "PF01429".
- Methyl-CpG-binding_domain pfamClan "CL0081".
- Methyl-CpG-binding_domain scop "1".
- Methyl-CpG-binding_domain symbol "MBD".
- Methyl-CpG-binding_domain wikiPageUsesTemplate Template:Infobox_protein_family.
- Methyl-CpG-binding_domain wikiPageUsesTemplate Template:InterPro_content.
- Methyl-CpG-binding_domain wikiPageUsesTemplate Template:Reflist.
- Methyl-CpG-binding_domain subject Category:Protein_domains.
- Methyl-CpG-binding_domain type Biomolecule.
- Methyl-CpG-binding_domain type Protein.
- Methyl-CpG-binding_domain type Chemical.
- Methyl-CpG-binding_domain type Domain.
- Methyl-CpG-binding_domain type Thing.
- Methyl-CpG-binding_domain type Q206229.
- Methyl-CpG-binding_domain type Q8054.
- Methyl-CpG-binding_domain comment "The Methyl-CpG-binding domain (MBD) in molecular biology binds to DNA that contains one or more symmetrically methylated CpGs. MBD has negligible non-specific affinity for unmethylated DNA.".
- Methyl-CpG-binding_domain label "Methyl-CpG-binding domain".
- Methyl-CpG-binding_domain sameAs Q6823921.
- Methyl-CpG-binding_domain sameAs m.0h3xksf.
- Methyl-CpG-binding_domain sameAs Q6823921.
- Methyl-CpG-binding_domain wasDerivedFrom Methyl-CpG-binding_domain?oldid=609107625.
- Methyl-CpG-binding_domain depiction PDB_1ub1_EBI.jpg.
- Methyl-CpG-binding_domain isPrimaryTopicOf Methyl-CpG-binding_domain.