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- Metaxalone abstract "Not to be confused with Metolazone, a diuretic.Metaxalone (marketed by King Pharmaceuticals under the brand name Skelaxin) is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. It is considered to be a moderately strong muscle relaxant, with relatively low incidence of side effects. Skelaxin is available in an 800 mg scored tablet. Possible side effects include nausea, vomiting, drowsiness and CNS side effects, such as dizziness, headache, and irritability.Metaxalone exhibits increased bioavailability when taken with food. Specifically, in one study, compared to fasted conditions, the presence of food at the time of drug administration increased Cmax by 77.5%, AUC0-t by 23.5%, and AUC0-∞ by 15.4%. Thus, based on the information in the labeling, patients receiving metaxalone therapy are directed to take metaxalone with food, and are informed that taking metaxalone with food results in an increase in the oral bioavailability of metaxalone compared to taking metaxalone without food.The metabolism of metaxalone involves the liver cytochrome P450 system. Based on the information in the labeling, patients receiving metaxalone therapy and physicians prescribing metaxalone are directed to take precaution when coadministering it with other medications involving the P450 system.Because of potential for side effects, this drug is considered high risk in the elderly.".
- Metaxalone atcPrefix "none".
- Metaxalone casNumber "1665-48-1".
- Metaxalone drugbank "DB00660".
- Metaxalone fdaUniiCode "1NMA9J598Y".
- Metaxalone iupacName "5-[(3,5-dimethylphenoxy)methyl]-1,3-oxazolidin-2-one".
- Metaxalone pubchem "15459".
- Metaxalone thumbnail Metaxalone.svg?width=300.
- Metaxalone wikiPageExternalLink www.skelaxin.com.
- Metaxalone wikiPageID "3127074".
- Metaxalone wikiPageLength "6258".
- Metaxalone wikiPageOutDegree "15".
- Metaxalone wikiPageRevisionID "705808945".
- Metaxalone wikiPageWikiLink Bioavailability.
- Metaxalone wikiPageWikiLink Category:Carbamates.
- Metaxalone wikiPageWikiLink Category:Drugs_with_unknown_mechanisms_of_action.
- Metaxalone wikiPageWikiLink Category:Muscle_relaxants.
- Metaxalone wikiPageWikiLink Category:Oxazolidines.
- Metaxalone wikiPageWikiLink Category:Phenol_ethers.
- Metaxalone wikiPageWikiLink Central_nervous_system.
- Metaxalone wikiPageWikiLink Depressant.
- Metaxalone wikiPageWikiLink Kidney.
- Metaxalone wikiPageWikiLink King_Pharmaceuticals.
- Metaxalone wikiPageWikiLink Liver.
- Metaxalone wikiPageWikiLink Metolazone.
- Metaxalone wikiPageWikiLink Muscle_relaxant.
- Metaxalone wikiPageWikiLink Sprain.
- Metaxalone wikiPageWikiLinkText "Metaxalone".
- Metaxalone wikiPageWikiLinkText "Skelaxin".
- Metaxalone wikiPageWikiLinkText "metaxalone".
- Metaxalone atcPrefix "none".
- Metaxalone bioavailability "Unknown".
- Metaxalone c "12".
- Metaxalone casNumber "1665".
- Metaxalone chembl "1079604".
- Metaxalone chemspiderid "14709".
- Metaxalone drugbank "DB00660".
- Metaxalone eliminationHalfLife "33120.0".
- Metaxalone excretion Kidney.
- Metaxalone h "15".
- Metaxalone inchi "1".
- Metaxalone inchikey "IMWZZHHPURKASS-UHFFFAOYAR".
- Metaxalone iupacName "5".
- Metaxalone iupharLigand "7609".
- Metaxalone kegg "D00773".
- Metaxalone legalUs "Rx-only".
- Metaxalone medlineplus "a682010".
- Metaxalone metabolism Liver.
- Metaxalone molecularWeight "221.252".
- Metaxalone n "1".
- Metaxalone o "3".
- Metaxalone pregnancyUs "C".
- Metaxalone pubchem "15459".
- Metaxalone routesOfAdministration "Oral".
- Metaxalone smiles "O=C2OCCN2".
- Metaxalone stdinchi "1".
- Metaxalone stdinchikey "IMWZZHHPURKASS-UHFFFAOYSA-N".
- Metaxalone tradename "Skelaxin".
- Metaxalone unii "1".
- Metaxalone verifiedrevid "458442143".
- Metaxalone width "200".
- Metaxalone wikiPageUsesTemplate Template:Cascite.
- Metaxalone wikiPageUsesTemplate Template:Chemspidercite.
- Metaxalone wikiPageUsesTemplate Template:Drugbankcite.
- Metaxalone wikiPageUsesTemplate Template:Drugbox.
- Metaxalone wikiPageUsesTemplate Template:Drugs.com.
- Metaxalone wikiPageUsesTemplate Template:Ebicite.
- Metaxalone wikiPageUsesTemplate Template:Fdacite.
- Metaxalone wikiPageUsesTemplate Template:Keggcite.
- Metaxalone wikiPageUsesTemplate Template:Muscle_relaxants.
- Metaxalone wikiPageUsesTemplate Template:Stdinchicite.
- Metaxalone subject Category:Carbamates.
- Metaxalone subject Category:Drugs_with_unknown_mechanisms_of_action.
- Metaxalone subject Category:Muscle_relaxants.
- Metaxalone subject Category:Oxazolidines.
- Metaxalone subject Category:Phenol_ethers.
- Metaxalone hypernym Relaxant.
- Metaxalone type ChemicalSubstance.
- Metaxalone type Drug.
- Metaxalone type Amide.
- Metaxalone type Carbamate.
- Metaxalone type Drug.
- Metaxalone type Ester.
- Metaxalone type Ether.
- Metaxalone type Heterocycle.
- Metaxalone type Redirect.
- Metaxalone type ChemicalObject.
- Metaxalone type Thing.
- Metaxalone type Q8386.
- Metaxalone comment "Not to be confused with Metolazone, a diuretic.Metaxalone (marketed by King Pharmaceuticals under the brand name Skelaxin) is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. It is considered to be a moderately strong muscle relaxant, with relatively low incidence of side effects.".
- Metaxalone label "Metaxalone".
- Metaxalone sameAs Q6823309.
- Metaxalone sameAs m.08t5w8.
- Metaxalone sameAs Metaksalon.
- Metaxalone sameAs Metaksalon.
- Metaxalone sameAs Q6823309.
- Metaxalone wasDerivedFrom Metaxalone?oldid=705808945.
- Metaxalone depiction Metaxalone.svg.
- Metaxalone isPrimaryTopicOf Metaxalone.