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- Mad1 abstract "Mad1 is a non-essential protein in yeast which has a function in the spindle assembly checkpoint (SAC).This checkpoint monitors chromosome attachment to spindle microtubules and prevents cells from starting anaphase until the spindle is built up. The name Mad refers to the observation that mutant cells are mitotic arrest deficient (MAD) during microtubule depolymerization. Mad1 recruits the anaphase inhibitor Mad2 to unattached kinetochores and is essential for Mad2-Cdc20 complex formation in vivo but not in vitro. In vivo, Mad1 acts as a competitive inhibitorof the Mad2-Cdc20 complex. Mad1 is phosphorylated by Mps1 which then leads together with other activities to the formation of the mitotic checkpoint complex (MCC). Thereby it inhibits the activity of the anaphase-promoting complex/cyclosome (APC/C). Homolog’s of Mad1 are conserved in eukaryotes from yeast to mammals.".
- Mad1 thumbnail Tetramer_Mad1_Mad2.png?width=300.
- Mad1 wikiPageID "26745362".
- Mad1 wikiPageLength "10832".
- Mad1 wikiPageOutDegree "37".
- Mad1 wikiPageRevisionID "705428521".
- Mad1 wikiPageWikiLink Anaphase.
- Mad1 wikiPageWikiLink Anaphase-promoting_complex.
- Mad1 wikiPageWikiLink BUB1.
- Mad1 wikiPageWikiLink CDC20.
- Mad1 wikiPageWikiLink Catalysis.
- Mad1 wikiPageWikiLink Category:Cell_cycle.
- Mad1 wikiPageWikiLink Category:Proteins.
- Mad1 wikiPageWikiLink Category:Saccharomyces_cerevisiae_genes.
- Mad1 wikiPageWikiLink Cell_cycle.
- Mad1 wikiPageWikiLink Chemical_decomposition.
- Mad1 wikiPageWikiLink Chemical_structure.
- Mad1 wikiPageWikiLink Chromatid.
- Mad1 wikiPageWikiLink Coiled_coil.
- Mad1 wikiPageWikiLink Eukaryote.
- Mad1 wikiPageWikiLink Hyperphosphorylation.
- Mad1 wikiPageWikiLink Kinase.
- Mad1 wikiPageWikiLink Kinetochore.
- Mad1 wikiPageWikiLink MAD3.
- Mad1 wikiPageWikiLink Mad2.
- Mad1 wikiPageWikiLink Metaphase.
- Mad1 wikiPageWikiLink Phosphorylation.
- Mad1 wikiPageWikiLink Prometaphase.
- Mad1 wikiPageWikiLink Protein.
- Mad1 wikiPageWikiLink Receptor_(biochemistry).
- Mad1 wikiPageWikiLink Spindle_checkpoint.
- Mad1 wikiPageWikiLink Yeast.
- Mad1 wikiPageWikiLink File:Dimer_Mad1_Mad2.png.
- Mad1 wikiPageWikiLink File:MAD1_function_in_SAC.jpg.
- Mad1 wikiPageWikiLinkText "Mad1".
- Mad1 caption "Crystal structure, tetramer of Mad1-Mad2 complex, yellow and red=Mad1 monomers, palegreen= Mad2 monomers".
- Mad1 chromosome "VII".
- Mad1 entrezchromosome "NC_001139.9".
- Mad1 entrezgene "852794".
- Mad1 genlocEnd "349368".
- Mad1 genlocStart "347119".
- Mad1 name "Mad1".
- Mad1 organism "S. cerevisiae S288c".
- Mad1 pdb "1".
- Mad1 refseqmrna "NM_001180951.3".
- Mad1 refseqprotein "NP_011429.3".
- Mad1 symbol "1.0".
- Mad1 taxid "559292".
- Mad1 uniprot "P40957".
- Mad1 wikiPageUsesTemplate Template:Infobox_nonhuman_protein.
- Mad1 wikiPageUsesTemplate Template:Reflist.
- Mad1 subject Category:Cell_cycle.
- Mad1 subject Category:Proteins.
- Mad1 subject Category:Saccharomyces_cerevisiae_genes.
- Mad1 hypernym Protein.
- Mad1 type Biomolecule.
- Mad1 type Protein.
- Mad1 type Biomolecule.
- Mad1 type Chemical.
- Mad1 type Nutrient.
- Mad1 comment "Mad1 is a non-essential protein in yeast which has a function in the spindle assembly checkpoint (SAC).This checkpoint monitors chromosome attachment to spindle microtubules and prevents cells from starting anaphase until the spindle is built up. The name Mad refers to the observation that mutant cells are mitotic arrest deficient (MAD) during microtubule depolymerization.".
- Mad1 label "Mad1".
- Mad1 sameAs m.0cn_lpj.
- Mad1 wasDerivedFrom Mad1?oldid=705428521.
- Mad1 depiction Tetramer_Mad1_Mad2.png.
- Mad1 isPrimaryTopicOf Mad1.