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- MODY_1 abstract "MODY 1 is a form of maturity onset diabetes of the young.MODY 1 is due to a loss-of-function mutation in the HNF4A gene on chromosome 20. This gene codes for HNF4-α protein also known as transcription factor 14 (TCF14). HNF4α controls function of HNF1α (see MODY 3; HNF1A) and perhaps HNF1β (MODY 5) as well. This transcription network plays a role in the early development of the pancreas, liver, and intestines. In the pancreas these genes influence expression of, among others, the genes for insulin, the principal glucose transporter (GLUT2), and several proteins involved in glucose and mitochondrial metabolism. Although pancreatic beta cells produce adequate insulin in infancy, the capacity for insulin production declines thereafter. Diabetes (persistent hyperglycemia) typically develops by early adult years, but may not appear until later decades. The degree of insulin deficiency is slowly progressive. Many patients with MODY 1 are treated with sulfonylureas for years before insulin is required.Liver effects are subtle and not clinically significant. Many people with this condition have low levels of triglycerides, lipoprotein(a), apolipoproteins AII and CIII.Mutations in the alternative promoter of HNF4A are linked to development of type 2 diabetes.".
- MODY_1 wikiPageID "22575013".
- MODY_1 wikiPageLength "2652".
- MODY_1 wikiPageOutDegree "16".
- MODY_1 wikiPageRevisionID "616226227".
- MODY_1 wikiPageWikiLink Apolipoprotein.
- MODY_1 wikiPageWikiLink Category:Diabetes.
- MODY_1 wikiPageWikiLink Chromosome_20_(human).
- MODY_1 wikiPageWikiLink GLUT2.
- MODY_1 wikiPageWikiLink Gastrointestinal_tract.
- MODY_1 wikiPageWikiLink Glucose_transporter.
- MODY_1 wikiPageWikiLink HNF1A.
- MODY_1 wikiPageWikiLink HNF1B.
- MODY_1 wikiPageWikiLink Hepatocyte_nuclear_factor_4.
- MODY_1 wikiPageWikiLink Lipoprotein(a).
- MODY_1 wikiPageWikiLink Liver.
- MODY_1 wikiPageWikiLink MODY_3.
- MODY_1 wikiPageWikiLink MODY_5.
- MODY_1 wikiPageWikiLink Maturity_onset_diabetes_of_the_young.
- MODY_1 wikiPageWikiLink Transcription_factor.
- MODY_1 wikiPageWikiLink Triglyceride.
- MODY_1 wikiPageWikiLinkText "MODY 1".
- MODY_1 name "MODY 1".
- MODY_1 omim "125850".
- MODY_1 wikiPageUsesTemplate Template:Citation_needed.
- MODY_1 wikiPageUsesTemplate Template:Endocrine-disease-stub.
- MODY_1 wikiPageUsesTemplate Template:Endocrine_pathology.
- MODY_1 wikiPageUsesTemplate Template:Gene.
- MODY_1 wikiPageUsesTemplate Template:Infobox_Disease.
- MODY_1 wikiPageUsesTemplate Template:Reflist.
- MODY_1 wikiPageUsesTemplate Template:Seealso.
- MODY_1 wikiPageUsesTemplate coregulator_deficiencies.
- MODY_1 subject Category:Diabetes.
- MODY_1 hypernym Form.
- MODY_1 type Diabete.
- MODY_1 type Thing.
- MODY_1 comment "MODY 1 is a form of maturity onset diabetes of the young.MODY 1 is due to a loss-of-function mutation in the HNF4A gene on chromosome 20. This gene codes for HNF4-α protein also known as transcription factor 14 (TCF14). HNF4α controls function of HNF1α (see MODY 3; HNF1A) and perhaps HNF1β (MODY 5) as well. This transcription network plays a role in the early development of the pancreas, liver, and intestines.".
- MODY_1 label "MODY 1".
- MODY_1 seeAlso Hepatocyte_nuclear_factor_4_alpha.
- MODY_1 sameAs Q6717000.
- MODY_1 sameAs m.05zm1x4.
- MODY_1 sameAs Q6717000.
- MODY_1 wasDerivedFrom MODY_1?oldid=616226227.
- MODY_1 isPrimaryTopicOf MODY_1.