Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/MEK_inhibitor> ?p ?o }
Showing triples 1 to 50 of
50
with 100 triples per page.
- MEK_inhibitor abstract "A MEK inhibitor is a chemical or drug that inhibits the mitogen-activated protein kinase kinase enzymes MEK1 and/or MEK2.They can be used to affect the MAPK/ERK pathway which is often overactive in some cancers. (See MAPK/ERK pathway#Clinical significance.)Hence MEK inhibitors have potential for treatment of some cancers, especially BRAF-mutated melanoma, and KRAS/BRAF mutated colorectal cancer.Some MEK inhibitors: Trametinib (GSK1120212), FDA-approved to treat BRAF-mutated melanoma. Also studied in combination with BRAF inhibitor dabrafenib to treat BRAF-mutated melanoma. Selumetinib, had a phase 2 clinical trial for non-small cell lung cancer (NSCLC) which demonstrated an improvement in PFS, and is now in phase III development in KRAS mutation positive NSCLC (SELECT-1,NCT01933932). Other clinical trials underway include uveal melanoma, differentiated thyroid carcinoma, and inoperable plexiforms associated with neurofibromatosis type 1 Cobimetinib or XL518, in a Phase III trial, in combination with vemurafenib (Zelboraf(R)), for treatment of advanced melanoma Binimetinib (MEK162), had phase 1 trial for biliary tract cancer and melanoma and in Sept 2014 reported encouraging results from a phase II clinical trial for NRAS melanoma. PD-325901, for breast cancer, colon cancer, and melanoma CI-1040, PD035901 TAK-733, preclinical for multiple myeloma.↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑".
- MEK_inhibitor wikiPageID "37952149".
- MEK_inhibitor wikiPageLength "4091".
- MEK_inhibitor wikiPageOutDegree "31".
- MEK_inhibitor wikiPageRevisionID "708085072".
- MEK_inhibitor wikiPageWikiLink BRAF_(gene).
- MEK_inhibitor wikiPageWikiLink Binimetinib.
- MEK_inhibitor wikiPageWikiLink CI-1040.
- MEK_inhibitor wikiPageWikiLink Category:Cell_signaling.
- MEK_inhibitor wikiPageWikiLink Category:Experimental_cancer_drugs.
- MEK_inhibitor wikiPageWikiLink Category:Protein_kinase_inhibitors.
- MEK_inhibitor wikiPageWikiLink Cholangiocarcinoma.
- MEK_inhibitor wikiPageWikiLink Clinical_trial.
- MEK_inhibitor wikiPageWikiLink Cobimetinib.
- MEK_inhibitor wikiPageWikiLink Colorectal_cancer.
- MEK_inhibitor wikiPageWikiLink Dabrafenib.
- MEK_inhibitor wikiPageWikiLink KRAS.
- MEK_inhibitor wikiPageWikiLink MAP2K1.
- MEK_inhibitor wikiPageWikiLink MAP2K2.
- MEK_inhibitor wikiPageWikiLink ERK_pathway.
- MEK_inhibitor wikiPageWikiLink MEK_inhibitor.
- MEK_inhibitor wikiPageWikiLink Melanoma.
- MEK_inhibitor wikiPageWikiLink Mitogen-activated_protein_kinase_kinase.
- MEK_inhibitor wikiPageWikiLink Multiple_myeloma.
- MEK_inhibitor wikiPageWikiLink Neuroblastoma_RAS_viral_oncogene_homolog.
- MEK_inhibitor wikiPageWikiLink Non-small-cell_lung_carcinoma.
- MEK_inhibitor wikiPageWikiLink PD-325901.
- MEK_inhibitor wikiPageWikiLink PD035901.
- MEK_inhibitor wikiPageWikiLink Selumetinib.
- MEK_inhibitor wikiPageWikiLink Trametinib.
- MEK_inhibitor wikiPageWikiLink Vemurafenib.
- MEK_inhibitor wikiPageWikiLinkText "MEK inhibitor".
- MEK_inhibitor wikiPageWikiLinkText "MEK-inhibitor".
- MEK_inhibitor wikiPageUsesTemplate Template:Antineoplastic-drug-stub.
- MEK_inhibitor wikiPageUsesTemplate Template:Reflist.
- MEK_inhibitor subject Category:Cell_signaling.
- MEK_inhibitor subject Category:Experimental_cancer_drugs.
- MEK_inhibitor subject Category:Protein_kinase_inhibitors.
- MEK_inhibitor hypernym Chemical.
- MEK_inhibitor type ChemicalCompound.
- MEK_inhibitor type Drug.
- MEK_inhibitor type Drug.
- MEK_inhibitor comment "A MEK inhibitor is a chemical or drug that inhibits the mitogen-activated protein kinase kinase enzymes MEK1 and/or MEK2.They can be used to affect the MAPK/ERK pathway which is often overactive in some cancers. (See MAPK/ERK pathway#Clinical significance.)Hence MEK inhibitors have potential for treatment of some cancers, especially BRAF-mutated melanoma, and KRAS/BRAF mutated colorectal cancer.Some MEK inhibitors: Trametinib (GSK1120212), FDA-approved to treat BRAF-mutated melanoma.".
- MEK_inhibitor label "MEK inhibitor".
- MEK_inhibitor sameAs Q17142288.
- MEK_inhibitor sameAs MAP-Kinase-Inhibitor.
- MEK_inhibitor sameAs m.0p8v7c6.
- MEK_inhibitor sameAs Q17142288.
- MEK_inhibitor wasDerivedFrom MEK_inhibitor?oldid=708085072.
- MEK_inhibitor isPrimaryTopicOf MEK_inhibitor.