Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Lysergic_acid_2-butyl_amide> ?p ?o }
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- Lysergic_acid_2-butyl_amide abstract "Lysergic acid 2-butyl amide (2-Butyllysergamide, LSB) is an analogue of LSD originally developed by Richard Pioch at Eli Lilly in the 1950s, but mostly publicised through research conducted by the team led by David E. Nichols at Purdue University. It is a structural isomer of LSD, with the two ethyl groups on the amide nitrogen having been replaced by a single butyl group, joined at the 2-position. It is one of the few lysergamide derivatives to exceed the potency of LSD in animal drug discrimination assays, with the (R) isomer having an ED50 of 33nmol/kg for producing drug-appropriate responding, vs 48nmol/kg for LSD itself. The corresponding (R)-2-pentyl analogue has higher binding affinity for the 5-HT1A and 5-HT2A receptors, but is less potent in producing drug-appropriate responding, suggesting that the butyl compound has a higher efficacy at the receptor target. The drug discrimination assay for LSD in rats involves both 5-HT1A and 5-HT2A mediated components, and while lysergic acid 2-butyl amide is more potent than LSD as a 5-HT1A agonist, it is slightly less potent as a 5-HT2A agonist, and so would probably be slightly less potent than LSD as a hallucinogen in humans. The main use for this drug has been in studies of the binding site at the 5-HT2A receptor through which LSD exerts most of its pharmacological effects, with the stereoselective activity of these unsymmetric monoalkyl lysergamides foreshadowing the subsequent development of compounds such as lysergic acid 2,4-dimethylazetidide (LSZ).".
- Lysergic_acid_2-butyl_amide casNumber "137765-82-3".
- Lysergic_acid_2-butyl_amide casSupplemental "(R,R) isomer, freebase".
- Lysergic_acid_2-butyl_amide casSupplemental "137765-83-4 (R,R) isomer, maleate salt".
- Lysergic_acid_2-butyl_amide iupacName "(8β)-6-Methyl-N-[(1R)-1-methylpropyl]-9,10-didehydroergoline-8-carboxamide".
- Lysergic_acid_2-butyl_amide pubchem "15119692".
- Lysergic_acid_2-butyl_amide thumbnail SBULSD.svg?width=300.
- Lysergic_acid_2-butyl_amide wikiPageID "19913799".
- Lysergic_acid_2-butyl_amide wikiPageLength "4032".
- Lysergic_acid_2-butyl_amide wikiPageOutDegree "16".
- Lysergic_acid_2-butyl_amide wikiPageRevisionID "685870826".
- Lysergic_acid_2-butyl_amide wikiPageWikiLink 5-HT1A_receptor.
- Lysergic_acid_2-butyl_amide wikiPageWikiLink 5-HT2A_receptor.
- Lysergic_acid_2-butyl_amide wikiPageWikiLink Category:Designer_drugs.
- Lysergic_acid_2-butyl_amide wikiPageWikiLink Category:Eli_Lilly_and_Company.
- Lysergic_acid_2-butyl_amide wikiPageWikiLink Category:Lysergamides.
- Lysergic_acid_2-butyl_amide wikiPageWikiLink David_E._Nichols.
- Lysergic_acid_2-butyl_amide wikiPageWikiLink Dissociation_constant.
- Lysergic_acid_2-butyl_amide wikiPageWikiLink Eli_Lilly_and_Company.
- Lysergic_acid_2-butyl_amide wikiPageWikiLink Intrinsic_activity.
- Lysergic_acid_2-butyl_amide wikiPageWikiLink Lysergic_acid_2,4-dimethylazetidide.
- Lysergic_acid_2-butyl_amide wikiPageWikiLink Lysergic_acid_3-pentyl_amide.
- Lysergic_acid_2-butyl_amide wikiPageWikiLink Lysergic_acid_diethylamide.
- Lysergic_acid_2-butyl_amide wikiPageWikiLink Methylisopropyllysergamide.
- Lysergic_acid_2-butyl_amide wikiPageWikiLink Purdue_University.
- Lysergic_acid_2-butyl_amide wikiPageWikiLink Receptor_(biochemistry).
- Lysergic_acid_2-butyl_amide wikiPageWikiLink Structural_isomer.
- Lysergic_acid_2-butyl_amide wikiPageWikiLinkText "''sec''-butyl".
- Lysergic_acid_2-butyl_amide wikiPageWikiLinkText "LSB".
- Lysergic_acid_2-butyl_amide wikiPageWikiLinkText "Lysergic acid 2-butyl amide".
- Lysergic_acid_2-butyl_amide c "20".
- Lysergic_acid_2-butyl_amide casNumber "137765".
- Lysergic_acid_2-butyl_amide casSupplemental "137765".
- Lysergic_acid_2-butyl_amide casSupplemental "isomer, freebase".
- Lysergic_acid_2-butyl_amide chemspiderid "23157987".
- Lysergic_acid_2-butyl_amide h "25".
- Lysergic_acid_2-butyl_amide inchi "1".
- Lysergic_acid_2-butyl_amide inchikey "NYFSQPDQLFFBRA-RVZJWNSFSA-N".
- Lysergic_acid_2-butyl_amide iupacName "-6".
- Lysergic_acid_2-butyl_amide molecularWeight "323.431".
- Lysergic_acid_2-butyl_amide n "3".
- Lysergic_acid_2-butyl_amide o "1".
- Lysergic_acid_2-butyl_amide pubchem "15119692".
- Lysergic_acid_2-butyl_amide smiles "CN1C[C@@H]C=C2C1CC3=CNC4=C3C2=CC=C4".
- Lysergic_acid_2-butyl_amide synonyms "(- N- - 2-butyl- 7-methyl- 4,6,6a,7,8,9- hexahydroindolo- [4,3-fg] quinoline- 9-carboxamide)".
- Lysergic_acid_2-butyl_amide verifiedrevid "419986581".
- Lysergic_acid_2-butyl_amide watchedfields "changed".
- Lysergic_acid_2-butyl_amide width "140".
- Lysergic_acid_2-butyl_amide wikiPageUsesTemplate Template:Cascite.
- Lysergic_acid_2-butyl_amide wikiPageUsesTemplate Template:Drugbox.
- Lysergic_acid_2-butyl_amide wikiPageUsesTemplate Template:Ergolines.
- Lysergic_acid_2-butyl_amide wikiPageUsesTemplate Template:Hallucinogenic_lysergamides.
- Lysergic_acid_2-butyl_amide wikiPageUsesTemplate Template:Reflist.
- Lysergic_acid_2-butyl_amide wikiPageUsesTemplate Template:Serotonergics.
- Lysergic_acid_2-butyl_amide subject Category:Designer_drugs.
- Lysergic_acid_2-butyl_amide subject Category:Eli_Lilly_and_Company.
- Lysergic_acid_2-butyl_amide subject Category:Lysergamides.
- Lysergic_acid_2-butyl_amide hypernym Analogue.
- Lysergic_acid_2-butyl_amide type ChemicalSubstance.
- Lysergic_acid_2-butyl_amide type Company.
- Lysergic_acid_2-butyl_amide type Drug.
- Lysergic_acid_2-butyl_amide type Amide.
- Lysergic_acid_2-butyl_amide type Chemical.
- Lysergic_acid_2-butyl_amide type Company.
- Lysergic_acid_2-butyl_amide type Dissociative.
- Lysergic_acid_2-butyl_amide type Drug.
- Lysergic_acid_2-butyl_amide type Lysergamide.
- Lysergic_acid_2-butyl_amide type ChemicalObject.
- Lysergic_acid_2-butyl_amide type Thing.
- Lysergic_acid_2-butyl_amide type Q8386.
- Lysergic_acid_2-butyl_amide comment "Lysergic acid 2-butyl amide (2-Butyllysergamide, LSB) is an analogue of LSD originally developed by Richard Pioch at Eli Lilly in the 1950s, but mostly publicised through research conducted by the team led by David E. Nichols at Purdue University. It is a structural isomer of LSD, with the two ethyl groups on the amide nitrogen having been replaced by a single butyl group, joined at the 2-position.".
- Lysergic_acid_2-butyl_amide label "Lysergic acid 2-butyl amide".
- Lysergic_acid_2-butyl_amide sameAs Q6710119.
- Lysergic_acid_2-butyl_amide sameAs m.04qbdbs.
- Lysergic_acid_2-butyl_amide sameAs Lizerginska_kiselina_2-butil_amid.
- Lysergic_acid_2-butyl_amide sameAs Lizerginska_kiselina_2-butil_amid.
- Lysergic_acid_2-butyl_amide sameAs Q6710119.
- Lysergic_acid_2-butyl_amide wasDerivedFrom Lysergic_acid_2-butyl_amide?oldid=685870826.
- Lysergic_acid_2-butyl_amide depiction SBULSD.svg.
- Lysergic_acid_2-butyl_amide isPrimaryTopicOf Lysergic_acid_2-butyl_amide.