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- Logan_plot abstract "A Logan plot (or Logan graphical analysis) is a graphical analysis technique based on the compartment model that uses linear regression to analyze pharmacokinetics of tracers involving reversible uptake. It is mainly used for the evaluation of nuclear medicine imaging data after the injection of a labeled ligand that binds reversibly to specific receptor or enzyme.In conventional compartmental analysis, an iterative method is used to fit the individual model parameters in the solution of a compartmental model of specific configuration to the measurements with a measured plasma time-activity curve that serves as an forcing (input) function, and the binding of the tracer can then be described. Graphical analysis is a simplified method that transforms the model equations into a linear equation evaluated at multiple time points and provides fewer parameters (i.e., slope and intercept). Although the slope and the intercept can be interpreted in terms of a combination of model parameters if a compartmental model configuration is assumed, the graphical methods are independent of any specific model configuration. In case of irreversible tracers, certain fraction of the radioactivity is trapped in the tissue or the binding site during the course of the experiment, whereas reversible tracers show uptake and loss from all compartments throughout the study. The theoretical foundation of graphical analysis for irreversible tracers (also called Patlak graphical analysis or Patlak plot) was laid by Clifford Patlak and his colleagues at NIH. Based on the original work of Patlak, Jean Logan and her colleagues from Brookhaven National Laboratory extended the method to tracers with reversible kinetics.".
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- Logan_plot wikiPageRevisionID "627469711".
- Logan_plot wikiPageWikiLink Binding_potential.
- Logan_plot wikiPageWikiLink Brookhaven_National_Laboratory.
- Logan_plot wikiPageWikiLink Category:Mathematical_modeling.
- Logan_plot wikiPageWikiLink Category:Plots_(graphics).
- Logan_plot wikiPageWikiLink Category:Systems_theory.
- Logan_plot wikiPageWikiLink Clifford_Patlak.
- Logan_plot wikiPageWikiLink Compartment_(pharmacokinetics).
- Logan_plot wikiPageWikiLink Dissociation_constant.
- Logan_plot wikiPageWikiLink Division_(mathematics).
- Logan_plot wikiPageWikiLink Enzyme.
- Logan_plot wikiPageWikiLink Graph_of_a_function.
- Logan_plot wikiPageWikiLink Iterative_method.
- Logan_plot wikiPageWikiLink Jean_Logan.
- Logan_plot wikiPageWikiLink Linear_regression.
- Logan_plot wikiPageWikiLink Medical_imaging.
- Logan_plot wikiPageWikiLink Molecular_binding.
- Logan_plot wikiPageWikiLink Multi-compartment_model.
- Logan_plot wikiPageWikiLink National_Institutes_of_Health.
- Logan_plot wikiPageWikiLink Nuclear_medicine.
- Logan_plot wikiPageWikiLink Partition_coefficient.
- Logan_plot wikiPageWikiLink Patlak_plot.
- Logan_plot wikiPageWikiLink Pharmacokinetics.
- Logan_plot wikiPageWikiLink Positron_emission_tomography.
- Logan_plot wikiPageWikiLink Receptor_(biochemistry).
- Logan_plot wikiPageWikiLink Region_of_interest.
- Logan_plot wikiPageWikiLink Volume_of_distribution.
- Logan_plot wikiPageWikiLinkText "Logan plot".
- Logan_plot wikiPageUsesTemplate Template:Reflist.
- Logan_plot subject Category:Mathematical_modeling.
- Logan_plot subject Category:Plots_(graphics).
- Logan_plot subject Category:Systems_theory.
- Logan_plot hypernym Technique.
- Logan_plot type TopicalConcept.
- Logan_plot type Chart.
- Logan_plot type Theory.
- Logan_plot comment "A Logan plot (or Logan graphical analysis) is a graphical analysis technique based on the compartment model that uses linear regression to analyze pharmacokinetics of tracers involving reversible uptake.".
- Logan_plot label "Logan plot".
- Logan_plot sameAs Q6667243.
- Logan_plot sameAs m.0hr3yc9.
- Logan_plot sameAs Q6667243.
- Logan_plot wasDerivedFrom Logan_plot?oldid=627469711.
- Logan_plot isPrimaryTopicOf Logan_plot.