Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Lofentanil> ?p ?o }
- Lofentanil abstract "Lofentanil is one of the most potent opioid analgesics known and is an analogue of fentanyl, which was developed in 1960. It is most similar to the highly potent opioid carfentanil (4-carbomethoxyfentanyl), only slightly more potent. Lofentanil can be described as 3-methylcarfentanil, or 3-methyl-4-carbomethoxyfentanyl. While 3-methylfentanyl is considerably more potent than fentanyl itself, lofentanil is only slightly stronger than carfentanil. This suggests that substitution at both the 3 and 4 positions of the piperidine ring introduces steric hindrance which prevents μ-opioid affinity from increasing much further. As with other 3-substituted fentanyl derivatives such as ohmefentanyl, the stereoisomerism of lofentanil is very important, with some stereoisomers being much more potent than others.Lofentanil is very similar to carfentanil in effects, but has a longer duration of action. This makes it unsuitable for most practical applications, with carfentanil being the preferred agent for tranquilizing large animals, and short-acting derivatives such as sufentanil or remifentanil being preferred for medical use in human surgical procedures. The long duration and high lipophilicity of lofentanil has been suggested as an advantage for certain types of analgesia, but the main application for lofentanil at the present time is research into opioid receptors.Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea, and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear. Side effects from lofentanil might be particularly problematic given its reportedly long duration of action. Another side effect which is characteristic of fentanyl and its derivatives is their tendency to rapidly induce tolerance, due to their high binding affinity triggering rapid internalization of chronically activated opiate receptors. This might be expected to be a particular problem with lofentanil as it is not only one of the most potent drugs in the series, but also is longer acting than most other fentanyl analogues, meaning that development of tolerance triggered by receptor over-activation is likely to be especially rapid, occurring with as little as a single active dose.".
- Lofentanil atcPrefix "none".
- Lofentanil casNumber "61380-40-3".
- Lofentanil fdaUniiCode "7H7YQ564XV".
- Lofentanil iupacName "methyl (3S,4R)-3-methyl-1-(2-phenylethyl)-4-[phenyl(propionyl)amino]piperidine-4-carboxylate".
- Lofentanil pubchem "10070040".
- Lofentanil thumbnail Lofentanil.svg?width=300.
- Lofentanil wikiPageID "12790638".
- Lofentanil wikiPageLength "7837".
- Lofentanil wikiPageOutDegree "26".
- Lofentanil wikiPageRevisionID "707115924".
- Lofentanil wikiPageWikiLink 3-Methylfentanyl.
- Lofentanil wikiPageWikiLink Analgesic.
- Lofentanil wikiPageWikiLink Carfentanil.
- Lofentanil wikiPageWikiLink Category:Anilines.
- Lofentanil wikiPageWikiLink Category:Carboxylate_esters.
- Lofentanil wikiPageWikiLink Category:Janssen_Pharmaceutica.
- Lofentanil wikiPageWikiLink Category:Mu-opioid_agonists.
- Lofentanil wikiPageWikiLink Category:Piperidines.
- Lofentanil wikiPageWikiLink Category:Propionamides.
- Lofentanil wikiPageWikiLink Category:Synthetic_opioids.
- Lofentanil wikiPageWikiLink Dissociation_constant.
- Lofentanil wikiPageWikiLink Fentanyl.
- Lofentanil wikiPageWikiLink Hypoventilation.
- Lofentanil wikiPageWikiLink Itch.
- Lofentanil wikiPageWikiLink Lipophilicity.
- Lofentanil wikiPageWikiLink Nausea.
- Lofentanil wikiPageWikiLink Ohmefentanyl.
- Lofentanil wikiPageWikiLink Opioid.
- Lofentanil wikiPageWikiLink Remifentanil.
- Lofentanil wikiPageWikiLink Stereoisomerism.
- Lofentanil wikiPageWikiLink Steric_effects.
- Lofentanil wikiPageWikiLink Structural_analog.
- Lofentanil wikiPageWikiLink Sufentanil.
- Lofentanil wikiPageWikiLink Tachyphylaxis.
- Lofentanil wikiPageWikiLink Μ-opioid_receptor.
- Lofentanil wikiPageWikiLinkText "Lofentanil".
- Lofentanil wikiPageWikiLinkText "Lofentanyl".
- Lofentanil wikiPageWikiLinkText "lofentanil".
- Lofentanil atcPrefix "none".
- Lofentanil c "25".
- Lofentanil casNumber "61380".
- Lofentanil chembl "28198".
- Lofentanil chemspiderid "8245580".
- Lofentanil h "32".
- Lofentanil inchi "1".
- Lofentanil inchikey "IMYHGORQCPYVBZ-NLFFAJNJBT".
- Lofentanil iupacName "methyl -3-methyl-1--4-[phenylamino]piperidine-4-carboxylate".
- Lofentanil legalDe "Anlage I".
- Lofentanil legalUk "Class A".
- Lofentanil molecularWeight "408.533".
- Lofentanil n "2".
- Lofentanil o "3".
- Lofentanil pubchem "10070040".
- Lofentanil smiles "O=C[C@]3CCNC[C@H]3C".
- Lofentanil stdinchi "1".
- Lofentanil stdinchikey "IMYHGORQCPYVBZ-NLFFAJNJSA-N".
- Lofentanil synonyms "Lofentanil; (methyl -1--4 --3-methylpiperidine-4-carboxylate)".
- Lofentanil unii "7".
- Lofentanil verifiedfields "changed".
- Lofentanil verifiedrevid "462093198".
- Lofentanil width "140".
- Lofentanil wikiPageUsesTemplate Template:Cascite.
- Lofentanil wikiPageUsesTemplate Template:Chemspidercite.
- Lofentanil wikiPageUsesTemplate Template:Drugbankcite.
- Lofentanil wikiPageUsesTemplate Template:Drugbox.
- Lofentanil wikiPageUsesTemplate Template:Ebicite.
- Lofentanil wikiPageUsesTemplate Template:Fdacite.
- Lofentanil wikiPageUsesTemplate Template:Opioidergics.
- Lofentanil wikiPageUsesTemplate Template:Reflist.
- Lofentanil wikiPageUsesTemplate Template:Stdinchicite.
- Lofentanil subject Category:Anilines.
- Lofentanil subject Category:Carboxylate_esters.
- Lofentanil subject Category:Janssen_Pharmaceutica.
- Lofentanil subject Category:Mu-opioid_agonists.
- Lofentanil subject Category:Piperidines.
- Lofentanil subject Category:Propionamides.
- Lofentanil subject Category:Synthetic_opioids.
- Lofentanil hypernym Analogue.
- Lofentanil type ChemicalSubstance.
- Lofentanil type Company.
- Lofentanil type Drug.
- Lofentanil type Agonist.
- Lofentanil type Amide.
- Lofentanil type Brand.
- Lofentanil type Chemical.
- Lofentanil type Company.
- Lofentanil type Drug.
- Lofentanil type Enamine.
- Lofentanil type Ester.
- Lofentanil type Heterocycle.
- Lofentanil type Opioid.
- Lofentanil type ChemicalObject.
- Lofentanil type Thing.
- Lofentanil type Q8386.
- Lofentanil comment "Lofentanil is one of the most potent opioid analgesics known and is an analogue of fentanyl, which was developed in 1960. It is most similar to the highly potent opioid carfentanil (4-carbomethoxyfentanyl), only slightly more potent. Lofentanil can be described as 3-methylcarfentanil, or 3-methyl-4-carbomethoxyfentanyl. While 3-methylfentanyl is considerably more potent than fentanyl itself, lofentanil is only slightly stronger than carfentanil.".
- Lofentanil label "Lofentanil".
- Lofentanil sameAs Q3836402.
- Lofentanil sameAs Lofentaniili.
- Lofentanil sameAs Lofentanil.