Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Linezolid> ?p ?o }
- Linezolid abstract "Linezolid is an antibiotic used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to other antibiotics. Linezolid is active against most Gram-positive bacteria that cause disease, including streptococci, vancomycin-resistant enterococci (VRE), and methicillin-resistant Staphylococcus aureus (MRSA). The main uses are infections of the skin and pneumonia although it may be use for a variety of other infections.When administered for short periods, linezolid is a relatively safe antibiotic. It can be used in people of all ages and in people with liver disease or poor kidney function. Common adverse effects of short-term use include headache, diarrhea, and nausea. Long-term use, however, has been associated with serious adverse effects such as bone marrow suppression and low platelet counts, particularly when used for more than two weeks. If used for longer periods still, it may cause sometimes irreversible chemotherapy-induced peripheral neuropathy and optic nerve damage, and lactic acidosis (a buildup of lactic acid in the body), all most likely due to mitochondrial toxicity.As a protein synthesis inhibitor, it stops the growth of bacteria by disrupting their production of proteins, that is, it is a bacteriostatic agent, not bacteriocidal. Although many antibiotics work this way, the exact mechanism of action of linezolid appears to be unique in that it blocks the initiation of protein production, and not one of the later steps. Bacterial resistance to linezolid has remained very low since it was first detected in 1999, although it may be increasing. It is a member of the oxazolidinone class of drugs.Linezolid was discovered in the 1990s by a team at Pharmacia and Upjohn Company and first approved for use in 2000. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. Linezolid costs approximately US$100 per tablet in the United States. Nonetheless, it appears to be more cost-effective than generic alternatives such as vancomycin, mostly because of the possibility of switching from intravenous to oral administration as soon as patients are stable enough, without the need for dose adjustments.".
- Linezolid atcPrefix "J01".
- Linezolid atcSuffix "XX08".
- Linezolid casNumber "165800-03-3".
- Linezolid drugbank "DB00601".
- Linezolid fdaUniiCode "ISQ9I6J12J".
- Linezolid iupacName "(S)-N-({3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide".
- Linezolid pubchem "441401".
- Linezolid thumbnail Linezolid.svg?width=300.
- Linezolid wikiPageID "424464".
- Linezolid wikiPageLength "89151".
- Linezolid wikiPageOutDegree "348".
- Linezolid wikiPageRevisionID "707998514".
- Linezolid wikiPageWikiLink 2-Oxazolidone.
- Linezolid wikiPageWikiLink 23S_ribosomal_RNA.
- Linezolid wikiPageWikiLink 30S.
- Linezolid wikiPageWikiLink 50S.
- Linezolid wikiPageWikiLink ATP-binding_cassette_transporter.
- Linezolid wikiPageWikiLink Acetamide.
- Linezolid wikiPageWikiLink Active_transport.
- Linezolid wikiPageWikiLink Adverse_drug_reaction.
- Linezolid wikiPageWikiLink Aglowmed.
- Linezolid wikiPageWikiLink American_Thoracic_Society.
- Linezolid wikiPageWikiLink clavulanic_acid.
- Linezolid wikiPageWikiLink sulbactam.
- Linezolid wikiPageWikiLink Antibiotic_candidiasis.
- Linezolid wikiPageWikiLink Antibiotics.
- Linezolid wikiPageWikiLink Anticoagulant.
- Linezolid wikiPageWikiLink Antimicrobial_pharmacodynamics.
- Linezolid wikiPageWikiLink Antimicrobial_resistance.
- Linezolid wikiPageWikiLink Archaea.
- Linezolid wikiPageWikiLink Area_under_the_curve_(pharmacokinetics).
- Linezolid wikiPageWikiLink Aryl.
- Linezolid wikiPageWikiLink Atom_economy.
- Linezolid wikiPageWikiLink Bacteremia.
- Linezolid wikiPageWikiLink Bacteria.
- Linezolid wikiPageWikiLink Bacterial_outer_membrane.
- Linezolid wikiPageWikiLink Bactericide.
- Linezolid wikiPageWikiLink Bacteriostatic_agent.
- Linezolid wikiPageWikiLink Base_pair.
- Linezolid wikiPageWikiLink Bells_palsy.
- Linezolid wikiPageWikiLink Binding_site.
- Linezolid wikiPageWikiLink Bioavailability.
- Linezolid wikiPageWikiLink Bioisostere.
- Linezolid wikiPageWikiLink Biological_activity.
- Linezolid wikiPageWikiLink Blood–brain_barrier.
- Linezolid wikiPageWikiLink Bone.
- Linezolid wikiPageWikiLink Bone_marrow_suppression.
- Linezolid wikiPageWikiLink Bordetella.
- Linezolid wikiPageWikiLink Bortezomib.
- Linezolid wikiPageWikiLink Breast_milk.
- Linezolid wikiPageWikiLink British_Thoracic_Society.
- Linezolid wikiPageWikiLink Bronchus.
- Linezolid wikiPageWikiLink Brookes.
- Linezolid wikiPageWikiLink Burn.
- Linezolid wikiPageWikiLink Capnocytophaga.
- Linezolid wikiPageWikiLink Carboplatin.
- Linezolid wikiPageWikiLink Case_report.
- Linezolid wikiPageWikiLink Category:2000_introductions.
- Linezolid wikiPageWikiLink Category:Monoamine_oxidase_inhibitors.
- Linezolid wikiPageWikiLink Category:Morpholines.
- Linezolid wikiPageWikiLink Category:Organofluorides.
- Linezolid wikiPageWikiLink Category:Oxazolidinone_antibiotics.
- Linezolid wikiPageWikiLink Category:Pfizer_products.
- Linezolid wikiPageWikiLink Category:World_Health_Organization_essential_medicines.
- Linezolid wikiPageWikiLink Ceftobiprole.
- Linezolid wikiPageWikiLink Cell_wall.
- Linezolid wikiPageWikiLink Central_nervous_system.
- Linezolid wikiPageWikiLink Central_venous_catheter.
- Linezolid wikiPageWikiLink Cephalosporin.
- Linezolid wikiPageWikiLink Cerebrospinal_fluid.
- Linezolid wikiPageWikiLink Changsha.
- Linezolid wikiPageWikiLink Chemotherapy-induced_peripheral_neuropathy.
- Linezolid wikiPageWikiLink Chloramphenicol.
- Linezolid wikiPageWikiLink Cipla.
- Linezolid wikiPageWikiLink Cisplatin.
- Linezolid wikiPageWikiLink Clearance_(medicine).
- Linezolid wikiPageWikiLink Clindamycin.
- Linezolid wikiPageWikiLink Clinical_trial.
- Linezolid wikiPageWikiLink Clostridium_difficile_colitis.
- Linezolid wikiPageWikiLink Community-acquired_pneumonia.
- Linezolid wikiPageWikiLink Complete_blood_count.
- Linezolid wikiPageWikiLink Conformational_change.
- Linezolid wikiPageWikiLink Convergent_synthesis.
- Linezolid wikiPageWikiLink Corynebacterium.
- Linezolid wikiPageWikiLink Cost-effectiveness_analysis.
- Linezolid wikiPageWikiLink Cross-resistance.
- Linezolid wikiPageWikiLink Crystal_structure.
- Linezolid wikiPageWikiLink Cytochrome_P450.
- Linezolid wikiPageWikiLink Dalbavancin.
- Linezolid wikiPageWikiLink Daptomycin.
- Linezolid wikiPageWikiLink Deinococcus_radiodurans.
- Linezolid wikiPageWikiLink Diabetic_foot.
- Linezolid wikiPageWikiLink Diarrhea.
- Linezolid wikiPageWikiLink Dicloxacillin.
- Linezolid wikiPageWikiLink Disease_burden.
- Linezolid wikiPageWikiLink Docetaxel.
- Linezolid wikiPageWikiLink Dr._Reddys_Laboratories.
- Linezolid wikiPageWikiLink Drug_development.
- Linezolid wikiPageWikiLink Drug_interaction.