Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Linaclotide> ?p ?o }
- Linaclotide abstract "Linaclotide (marketed under the trade name Linzess and Constella) is a peptide agonist of the guanylate cyclase 2C. This compound reduces activation of colonic sensory neurons, reducing pain; and activates colonic motor neurons, which increases smooth muscle contraction and thus promotes bowel movements. It was approved by the FDA in August 2012 for the treatment of chronic idiopathic constipation and constipation predominant irritable bowel syndrome (IBS-C) in adults.The National Institutes of Health (NIH) estimate that as many as 20% of Americans may experience signs of irritable bowel syndrome, with approximately one-third of those affected experiencing constipation often accompanied by abdominal pain, affecting as many as 10 million Americans. Laxatives can assist with constipation but do not treat pain, while use of opiates to treat pain can aggravate constipation. While low-cost laxatives and pain killers would likely be tried first, linaclotide targets both associated conditions in a once-daily pill.".
- Linaclotide atcPrefix "A06".
- Linaclotide atcSuffix "AX04".
- Linaclotide casNumber "851199-59-2".
- Linaclotide fdaUniiCode "N0TXR0XR5X".
- Linaclotide iupacName "(L)-Cysteinyl-(L)-cysteinyl-(L)-glutamyl-(L)-tyrosyl-(L)-cysteinyl-(L)-cysteinyl-(L)-asparaginyl-(L)-prolyl-(L)-alanyl-(L)-cysteinyl-(L)-threonylglycyl-(L)-cysteinyl-(L)-tyrosine cyclo(1-6),(2-10),(5-13)-tris(disulfide)".
- Linaclotide pubchem "16158208".
- Linaclotide thumbnail Linaclotide_structure.svg?width=300.
- Linaclotide wikiPageExternalLink linzess.html.
- Linaclotide wikiPageID "28829324".
- Linaclotide wikiPageLength "7642".
- Linaclotide wikiPageOutDegree "28".
- Linaclotide wikiPageRevisionID "698297101".
- Linaclotide wikiPageWikiLink Agonist.
- Linaclotide wikiPageWikiLink Alanine.
- Linaclotide wikiPageWikiLink Almirall.
- Linaclotide wikiPageWikiLink Amino_acid.
- Linaclotide wikiPageWikiLink Asparagine.
- Linaclotide wikiPageWikiLink Astellas_Pharma.
- Linaclotide wikiPageWikiLink Category:Drugs_acting_on_the_gastrointestinal_system_and_metabolism.
- Linaclotide wikiPageWikiLink Category:Laxatives.
- Linaclotide wikiPageWikiLink Category:Peptides.
- Linaclotide wikiPageWikiLink Cysteine.
- Linaclotide wikiPageWikiLink Diarrhea.
- Linaclotide wikiPageWikiLink Disulfide.
- Linaclotide wikiPageWikiLink Forest_Laboratories.
- Linaclotide wikiPageWikiLink Functional_constipation.
- Linaclotide wikiPageWikiLink Glutamic_acid.
- Linaclotide wikiPageWikiLink Glycine.
- Linaclotide wikiPageWikiLink Guanylate_cyclase_2C.
- Linaclotide wikiPageWikiLink Irritable_bowel_syndrome.
- Linaclotide wikiPageWikiLink Laxative.
- Linaclotide wikiPageWikiLink National_Institutes_of_Health.
- Linaclotide wikiPageWikiLink Opiate.
- Linaclotide wikiPageWikiLink Peptide.
- Linaclotide wikiPageWikiLink Proline.
- Linaclotide wikiPageWikiLink Smooth_muscle_tissue.
- Linaclotide wikiPageWikiLink The_American_Journal_of_Gastroenterology.
- Linaclotide wikiPageWikiLink Threonine.
- Linaclotide wikiPageWikiLink Tyrosine.
- Linaclotide wikiPageWikiLink File:Linaclotide_schematic.svg.
- Linaclotide wikiPageWikiLinkText "Linaclotide".
- Linaclotide wikiPageWikiLinkText "Linzess".
- Linaclotide wikiPageWikiLinkText "linaclotide".
- Linaclotide atcPrefix "A06".
- Linaclotide atcSuffix "AX04".
- Linaclotide c "59".
- Linaclotide casNumber "851199".
- Linaclotide chemspiderid "17314504".
- Linaclotide h "79".
- Linaclotide iupacName "(L)-Cysteinyl-(L)-cysteinyl-(L)-glutamyl-(L)-tyrosyl-(L)-cysteinyl-(L)-cysteinyl-(L)-asparaginyl-(L)-prolyl-(L)-alanyl-(L)-cysteinyl-(L)-threonylglycyl-(L)-cysteinyl-(L)-tyrosine cyclo,,-tris".
- Linaclotide iupharLigand "5017".
- Linaclotide kegg "D09355".
- Linaclotide legalUs "Rx-only".
- Linaclotide licenceUs "Linaclotide".
- Linaclotide molecularWeight "1526.74".
- Linaclotide n "15".
- Linaclotide o "21".
- Linaclotide pregnancyUs "C".
- Linaclotide pubchem "16158208".
- Linaclotide routesOfAdministration "Oral".
- Linaclotide s "6".
- Linaclotide smiles "O=C[C@@H]Cc6ccccc6".
- Linaclotide stdinchi "1".
- Linaclotide stdinchikey "KXGCNMMJRFDFNR-WDRJZQOASA-N".
- Linaclotide tradename "Linzess".
- Linaclotide unii "N0TXR0XR5X".
- Linaclotide verifiedfields "changed".
- Linaclotide verifiedrevid "451564024".
- Linaclotide watchedfields "changed".
- Linaclotide width "315".
- Linaclotide wikiPageUsesTemplate Template:Cascite.
- Linaclotide wikiPageUsesTemplate Template:Chemspidercite.
- Linaclotide wikiPageUsesTemplate Template:Clear_left.
- Linaclotide wikiPageUsesTemplate Template:Drugbankcite.
- Linaclotide wikiPageUsesTemplate Template:Drugbox.
- Linaclotide wikiPageUsesTemplate Template:Fdacite.
- Linaclotide wikiPageUsesTemplate Template:Keggcite.
- Linaclotide wikiPageUsesTemplate Template:Laxatives.
- Linaclotide wikiPageUsesTemplate Template:Reflist.
- Linaclotide wikiPageUsesTemplate Template:Stdinchicite.
- Linaclotide subject Category:Drugs_acting_on_the_gastrointestinal_system_and_metabolism.
- Linaclotide subject Category:Laxatives.
- Linaclotide subject Category:Peptides.
- Linaclotide hypernym Agonist.
- Linaclotide type Biomolecule.
- Linaclotide type ChemicalSubstance.
- Linaclotide type Drug.
- Linaclotide type Biomolecule.
- Linaclotide type Drug.
- Linaclotide type Peptide.
- Linaclotide type Redirect.
- Linaclotide type ChemicalObject.
- Linaclotide type Thing.
- Linaclotide type Q8386.
- Linaclotide comment "Linaclotide (marketed under the trade name Linzess and Constella) is a peptide agonist of the guanylate cyclase 2C. This compound reduces activation of colonic sensory neurons, reducing pain; and activates colonic motor neurons, which increases smooth muscle contraction and thus promotes bowel movements.".
- Linaclotide label "Linaclotide".
- Linaclotide sameAs Q3832559.
- Linaclotide sameAs Linaclotide.
- Linaclotide sameAs Linaclotide.