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- Levomefolic_acid abstract "Levomefolic acid (INN) (also known as 5-MTHF, L-methylfolate and 5-methyltetrahydrofolate and (6S)-5-methyltetrahydrofolate, and (6S)-5-MTHF) is the primary biologically active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine. It is also the form found in circulation and transported across membranes into tissues and across the blood-brain barrier. In the cell, L-methylfolate is used in the methylation of homocysteine to form methionine and tetrahydrofolate (THF). THF is the immediate acceptor of one carbon units for the synthesis of thymidine-DNA, purines (RNA and DNA) and methionine. The un-methylated form, folic acid (vitamin B9), is a synthetic form of folate, and must undergo enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR) to become biologically active.It is synthesized in the absorptive cells of the small intestine from polyglutamylated dietary folate. It is a methylated derivative of tetrahydrofolate. Levomefolic acid is generated by MTHFR from 5,10-methylenetetrahydrofolate (MTHF) and used to recycle homocysteine back to methionine by 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) also known as methionine synthase (MS).L-methylfolate is water-soluble and primarily excreted via the kidneys. In a study of 21 subjects with coronary artery disease, peak plasma levels were reached in one to three hours following oral or parenteral administration. Peak concentrations were found to be more than seven times higher than folic acid (129 ng/ml vs. 14.1 ng/ml).Levomefolic acid (and folic acid in turn) has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers. It bypasses several metabolic steps in the body and better binds thymidylate synthase with fDump, a metabolite of the drug fluorouracil.Levomefolate calcium, a calcium salt of levomefolic acid, is sold under the brand names Metafolin (a registered trademark of Merck KGaA) and Deplin (trademark of Pamlab, LLC). Methyl folate can be bought at online stores or in some chemists though without a prescription.".
- Levomefolic_acid iupacName "(2S)-2-[ [4-[(2-Amino-5-methyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl) methylamino]benzoyl]amino]pentanedioic acid".
- Levomefolic_acid thumbnail 5-Methyltetrahydrofolate.png?width=300.
- Levomefolic_acid wikiPageExternalLink article_pf.aspx?articleid=1267.
- Levomefolic_acid wikiPageExternalLink bm5.3.
- Levomefolic_acid wikiPageExternalLink 16933051.
- Levomefolic_acid wikiPageID "11437063".
- Levomefolic_acid wikiPageLength "10646".
- Levomefolic_acid wikiPageOutDegree "35".
- Levomefolic_acid wikiPageRevisionID "693121719".
- Levomefolic_acid wikiPageWikiLink 5,10-Methylenetetrahydrofolate.
- Levomefolic_acid wikiPageWikiLink Category:Coenzymes.
- Levomefolic_acid wikiPageWikiLink Category:Folates.
- Levomefolic_acid wikiPageWikiLink Category:Patent_case_law.
- Levomefolic_acid wikiPageWikiLink Cerefolin.
- Levomefolic_acid wikiPageWikiLink Colorectal_cancer.
- Levomefolic_acid wikiPageWikiLink Cysteine.
- Levomefolic_acid wikiPageWikiLink DNA.
- Levomefolic_acid wikiPageWikiLink Fluorouracil.
- Levomefolic_acid wikiPageWikiLink Folic_acid.
- Levomefolic_acid wikiPageWikiLink Homocysteine.
- Levomefolic_acid wikiPageWikiLink International_nonproprietary_name.
- Levomefolic_acid wikiPageWikiLink Merck_Group.
- Levomefolic_acid wikiPageWikiLink Metanx.
- Levomefolic_acid wikiPageWikiLink Methionine.
- Levomefolic_acid wikiPageWikiLink Methionine_synthase.
- Levomefolic_acid wikiPageWikiLink Methylation.
- Levomefolic_acid wikiPageWikiLink Methylenetetrahydrofolate_reductase.
- Levomefolic_acid wikiPageWikiLink Orders_of_magnitude_(mass).
- Levomefolic_acid wikiPageWikiLink Pamlab.
- Levomefolic_acid wikiPageWikiLink Route_of_administration.
- Levomefolic_acid wikiPageWikiLink S-Adenosyl_methionine.
- Levomefolic_acid wikiPageWikiLink Salt_(chemistry).
- Levomefolic_acid wikiPageWikiLink Switzerland.
- Levomefolic_acid wikiPageWikiLink Tetrahydrofolic_acid.
- Levomefolic_acid wikiPageWikiLink Thymidylate_synthase.
- Levomefolic_acid wikiPageWikiLink United_States_District_Court_for_the_Eastern_District_of_Texas.
- Levomefolic_acid wikiPageWikiLink United_States_International_Trade_Commission.
- Levomefolic_acid wikiPageWikiLink File:MTHFR_metabolism.svg.
- Levomefolic_acid wikiPageWikiLinkText "5-Methyl tetrahydrofolate".
- Levomefolic_acid wikiPageWikiLinkText "5-methyltetrahydrofolate".
- Levomefolic_acid wikiPageWikiLinkText "L-methylfolate".
- Levomefolic_acid wikiPageWikiLinkText "Levomefolic acid".
- Levomefolic_acid wikiPageWikiLinkText "levomefolic acid".
- Levomefolic_acid wikiPageWikiLinkText "methyl tetrahydrofolate".
- Levomefolic_acid wikiPageWikiLinkText "methyltetrahydrofolate".
- Levomefolic_acid imagefile "5".
- Levomefolic_acid imagesize "220".
- Levomefolic_acid iupacname "-2".
- Levomefolic_acid othernames ",".
- Levomefolic_acid othernames "Alfive".
- Levomefolic_acid othernames "Metafolin, Extrafolate-S".
- Levomefolic_acid othernames "anion: 5-methyltetrahydrofolate , (L)-methylfolate".
- Levomefolic_acid wikiPageUsesTemplate Template:Chembox.
- Levomefolic_acid wikiPageUsesTemplate Template:Chembox_Hazards.
- Levomefolic_acid wikiPageUsesTemplate Template:Chembox_Identifiers.
- Levomefolic_acid wikiPageUsesTemplate Template:Chembox_Pharmacology.
- Levomefolic_acid wikiPageUsesTemplate Template:Chembox_Properties.
- Levomefolic_acid wikiPageUsesTemplate Template:Citation_needed.
- Levomefolic_acid wikiPageUsesTemplate Template:Cite_journal.
- Levomefolic_acid wikiPageUsesTemplate Template:Fdacite.
- Levomefolic_acid wikiPageUsesTemplate Template:Patent.
- Levomefolic_acid wikiPageUsesTemplate Template:Uscsub.
- Levomefolic_acid wikiPageUsesTemplate Template:Use_dmy_dates.
- Levomefolic_acid wikiPageUsesTemplate Template:Vitamin.
- Levomefolic_acid wikiPageUsesTemplate Template:Where.
- Levomefolic_acid subject Category:Coenzymes.
- Levomefolic_acid subject Category:Folates.
- Levomefolic_acid subject Category:Patent_case_law.
- Levomefolic_acid hypernym Primary.
- Levomefolic_acid type ChemicalCompound.
- Levomefolic_acid type ChemicalSubstance.
- Levomefolic_acid type School.
- Levomefolic_acid type Amide.
- Levomefolic_acid type Cofactor.
- Levomefolic_acid type Redirect.
- Levomefolic_acid type ChemicalObject.
- Levomefolic_acid type Thing.
- Levomefolic_acid type Q11173.
- Levomefolic_acid comment "Levomefolic acid (INN) (also known as 5-MTHF, L-methylfolate and 5-methyltetrahydrofolate and (6S)-5-methyltetrahydrofolate, and (6S)-5-MTHF) is the primary biologically active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine. It is also the form found in circulation and transported across membranes into tissues and across the blood-brain barrier.".
- Levomefolic_acid label "Levomefolic acid".
- Levomefolic_acid sameAs Q192553.
- Levomefolic_acid sameAs Ácido_levomefólico.
- Levomefolic_acid sameAs لوومفولیک_اسید.
- Levomefolic_acid sameAs Acide_5-méthyltétrahydrofolique.
- Levomefolic_acid sameAs Acido_5-metiltetraidrofolico.
- Levomefolic_acid sameAs 5-メチルテトラヒドロ葉酸.
- Levomefolic_acid sameAs Kwas_lewomefoliowy.
- Levomefolic_acid sameAs m.02rcj6v.
- Levomefolic_acid sameAs Levomefolna_kiselina.
- Levomefolic_acid sameAs Levomefolna_kiselina.
- Levomefolic_acid sameAs Q192553.
- Levomefolic_acid wasDerivedFrom Levomefolic_acid?oldid=693121719.
- Levomefolic_acid depiction 5-Methyltetrahydrofolate.png.
- Levomefolic_acid isPrimaryTopicOf Levomefolic_acid.