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- Leukotriene_C4 abstract "Leukotriene C4 (LTC4) is a leukotriene. LTC4 has been extensively studied in the context of allergy and asthma. In cells of myeloid origin such as mast cells, its biosynthesis is orchestrated by translocation to the nuclear envelope along with co-localization of cytosolic phospholipase A2 (cPLA2), Arachidonate 5-lipoxygenase (5-LO), 5-lipoxygenase-activating protein (FLAP) and LTC4 synthase (LTC4S), which couples glutathione to an LTA4 intermediate.The MRP1 transporter then secretes cytosolic LTC4 and cell surface proteases further metabolize it by sequential cleavage of the γ-glutamyl and glycine residues off its glutathione segment, generating the more stable products LTD4 and LTE4. All three leukotrienes then bind at different affinities to two G-protein coupled receptors: CYSLTR1 and CYSLTR2, triggering pulmonary vasoconstriction and bronchoconstriction.In cells of non-haematopoietic lineage, endoplasmic reticulum (ER) stress and chemotherapy induce LTC4 biosynthesis by transcriptionally upregulating and activating the enzyme microsomal glutathione-S-transferase 2 (MGST2). ER stress and chemotherapy also trigger nuclear translocation of the two LTC4 receptors. Acting in an intracrine manner, LTC4 then elicits nuclear translocation of NADPH oxidase 4 (NOX4), ROS accumulation and oxidative DNA damage. Besides being a potent lipid mediator in asthma and inflammation, LTC4 was reported to be involved in several other diseases, such as allergic airway diseases, dermatological diseases, cardiovascular diseases, liver injury, atherosclerosis and colon cancer.".
- Leukotriene_C4 thumbnail Leukotriene_C4.svg?width=300.
- Leukotriene_C4 wikiPageID "10993389".
- Leukotriene_C4 wikiPageLength "5963".
- Leukotriene_C4 wikiPageOutDegree "30".
- Leukotriene_C4 wikiPageRevisionID "701062438".
- Leukotriene_C4 wikiPageWikiLink 5-lipoxygenase-activating_protein.
- Leukotriene_C4 wikiPageWikiLink ABCC1.
- Leukotriene_C4 wikiPageWikiLink Allergy.
- Leukotriene_C4 wikiPageWikiLink Arachidonate_5-lipoxygenase.
- Leukotriene_C4 wikiPageWikiLink Asthma.
- Leukotriene_C4 wikiPageWikiLink Bronchoconstriction.
- Leukotriene_C4 wikiPageWikiLink Category:Eicosanoids.
- Leukotriene_C4 wikiPageWikiLink Chemotherapy.
- Leukotriene_C4 wikiPageWikiLink Cysteinyl_leukotriene_receptor_1.
- Leukotriene_C4 wikiPageWikiLink Cysteinyl_leukotriene_receptor_2.
- Leukotriene_C4 wikiPageWikiLink Endoplasmic_reticulum.
- Leukotriene_C4 wikiPageWikiLink File:Eicosanoid_synthesis.png.
- Leukotriene_C4 wikiPageWikiLink G_protein–coupled_receptor.
- Leukotriene_C4 wikiPageWikiLink Glutamic_acid.
- Leukotriene_C4 wikiPageWikiLink Glutathione.
- Leukotriene_C4 wikiPageWikiLink Glycine.
- Leukotriene_C4 wikiPageWikiLink Haematopoiesis.
- Leukotriene_C4 wikiPageWikiLink Intracrine.
- Leukotriene_C4 wikiPageWikiLink Leukotriene.
- Leukotriene_C4 wikiPageWikiLink Leukotriene_A4.
- Leukotriene_C4 wikiPageWikiLink Leukotriene_C4_synthase.
- Leukotriene_C4 wikiPageWikiLink Leukotriene_D4.
- Leukotriene_C4 wikiPageWikiLink Leukotriene_E4.
- Leukotriene_C4 wikiPageWikiLink MGST2.
- Leukotriene_C4 wikiPageWikiLink Mast_cell.
- Leukotriene_C4 wikiPageWikiLink Myeloid.
- Leukotriene_C4 wikiPageWikiLink NOX4.
- Leukotriene_C4 wikiPageWikiLink Nuclear_membrane.
- Leukotriene_C4 wikiPageWikiLink PLA2G4A.
- Leukotriene_C4 wikiPageWikiLink Vasoconstriction.
- Leukotriene_C4 wikiPageWikiLinkText "C4".
- Leukotriene_C4 wikiPageWikiLinkText "LTC4".
- Leukotriene_C4 wikiPageWikiLinkText "Leukotriene C4".
- Leukotriene_C4 wikiPageWikiLinkText "leukotriene C4".
- Leukotriene_C4 imagefile "Leukotriene C4.svg".
- Leukotriene_C4 verifiedrevid "396932578".
- Leukotriene_C4 wikiPageUsesTemplate Template:Biochemistry-stub.
- Leukotriene_C4 wikiPageUsesTemplate Template:Cascite.
- Leukotriene_C4 wikiPageUsesTemplate Template:Chembox.
- Leukotriene_C4 wikiPageUsesTemplate Template:Chembox_Hazards.
- Leukotriene_C4 wikiPageUsesTemplate Template:Chembox_Identifiers.
- Leukotriene_C4 wikiPageUsesTemplate Template:Chembox_Properties.
- Leukotriene_C4 wikiPageUsesTemplate Template:Ebicite.
- Leukotriene_C4 wikiPageUsesTemplate Template:Keggcite.
- Leukotriene_C4 wikiPageUsesTemplate Template:Leukotrienergics.
- Leukotriene_C4 wikiPageUsesTemplate Template:Leukotrienes.
- Leukotriene_C4 wikiPageUsesTemplate Template:Reflist.
- Leukotriene_C4 subject Category:Eicosanoids.
- Leukotriene_C4 hypernym Leukotriene.
- Leukotriene_C4 type ChemicalCompound.
- Leukotriene_C4 type ChemicalSubstance.
- Leukotriene_C4 type Lipid.
- Leukotriene_C4 type Chemical.
- Leukotriene_C4 type Eicosanoid.
- Leukotriene_C4 type Hormone.
- Leukotriene_C4 type Lipid.
- Leukotriene_C4 type ChemicalObject.
- Leukotriene_C4 type Thing.
- Leukotriene_C4 type Q11173.
- Leukotriene_C4 comment "Leukotriene C4 (LTC4) is a leukotriene. LTC4 has been extensively studied in the context of allergy and asthma.".
- Leukotriene_C4 label "Leukotriene C4".
- Leukotriene_C4 sameAs Q2704310.
- Leukotriene_C4 sameAs لوکوترین_سی۴.
- Leukotriene_C4 sameAs Leucotriène_C4.
- Leukotriene_C4 sameAs Leucotrieno_C4.
- Leukotriene_C4 sameAs m.02qxjld.
- Leukotriene_C4 sameAs Leukotrien_C4.
- Leukotriene_C4 sameAs Leukotrien_C4.
- Leukotriene_C4 sameAs Q2704310.
- Leukotriene_C4 sameAs 白三烯C4.
- Leukotriene_C4 wasDerivedFrom Leukotriene_C4?oldid=701062438.
- Leukotriene_C4 depiction Leukotriene_C4.svg.
- Leukotriene_C4 isPrimaryTopicOf Leukotriene_C4.