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- Leptomycin abstract "Leptomycin B is a secondary metabolite produced by Streptomyces spp.Leptomycin B (LMB) was originally discovered as a potent anti-fungal antibiotic. Leptomycin B was found to cause cell elongation of the fission yeast Schizosaccharomyces pombe. Since then this elongation effect has been used for the bioassay of leptomycin. However, recent data shows that Leptomycin causes G1 cell cycle arrest in mammalian cells and is a potent anti-tumor agent against murine experimental tumors in combination therapy.Leptomycin B has been shown to be a potent and specific nuclear export inhibitor in human and the fission yeast Schizosaccharomyces pombe. Leptomycin B alkylates and inhibits CRM1 (chromosomal region maintenance)/exportin 1 (XPO1), a protein required for nuclear export of proteins containing a nuclear export sequence (NES), by glycosylating a cysteine residue (cysteine 529 in S. pombe). In addition to antifungal and antibacterial activities, Leptomycin B blocks the cell cycle and is a potent anti-tumor agent. At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it inhibits the inactivation of p53. Leptomycin B also inhibits the export and translation of many RNAs, including COX-2 and c-Fos mRNAs, by inhibiting export of ribonucleoproteins.Leptomycin A (LPA) was discovered together with LMB. LMB is twice as potent as LPA.".
- Leptomycin iupacName "(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-".
- Leptomycin iupacName "17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-".
- Leptomycin iupacName "19-[(2S,3S)-3-methyl-6-oxo-2,3-dihydropyran-".
- Leptomycin iupacName "2-yl]-8-oxononadeca-2,10,12,16,18-pentaenoic acid".
- Leptomycin thumbnail Leptomycin_B.svg?width=300.
- Leptomycin wikiPageExternalLink leptomycin_B.htm.
- Leptomycin wikiPageID "4282370".
- Leptomycin wikiPageLength "5711".
- Leptomycin wikiPageOutDegree "22".
- Leptomycin wikiPageRevisionID "678945682".
- Leptomycin wikiPageWikiLink Antibiotics.
- Leptomycin wikiPageWikiLink Antifungal.
- Leptomycin wikiPageWikiLink Bioassay.
- Leptomycin wikiPageWikiLink C-Fos.
- Leptomycin wikiPageWikiLink Category:Antibiotics.
- Leptomycin wikiPageWikiLink Chemotherapy.
- Leptomycin wikiPageWikiLink Cysteine.
- Leptomycin wikiPageWikiLink Fermentek.
- Leptomycin wikiPageWikiLink Karyopherin.
- Leptomycin wikiPageWikiLink ERK_pathway.
- Leptomycin wikiPageWikiLink Metabolite.
- Leptomycin wikiPageWikiLink NF-κB.
- Leptomycin wikiPageWikiLink Nuclear_export_signal.
- Leptomycin wikiPageWikiLink P53.
- Leptomycin wikiPageWikiLink Prostaglandin-endoperoxide_synthase_2.
- Leptomycin wikiPageWikiLink RNA.
- Leptomycin wikiPageWikiLink Rev_(HIV).
- Leptomycin wikiPageWikiLink Ribonucleoprotein.
- Leptomycin wikiPageWikiLink Schizosaccharomyces_pombe.
- Leptomycin wikiPageWikiLink Streptomyces.
- Leptomycin wikiPageWikiLinkText "Leptomycin".
- Leptomycin wikiPageWikiLinkText "lemtomycin B".
- Leptomycin wikiPageWikiLinkText "leptomycin".
- Leptomycin imagefile "Leptomycin B.svg".
- Leptomycin iupacname "-".
- Leptomycin iupacname "17".
- Leptomycin iupacname "19".
- Leptomycin iupacname "2".
- Leptomycin verifiedrevid "450847443".
- Leptomycin watchedfields "changed".
- Leptomycin wikiPageUsesTemplate Template:Cascite.
- Leptomycin wikiPageUsesTemplate Template:Chembox.
- Leptomycin wikiPageUsesTemplate Template:Chembox_Hazards.
- Leptomycin wikiPageUsesTemplate Template:Chembox_Identifiers.
- Leptomycin wikiPageUsesTemplate Template:Chembox_Properties.
- Leptomycin wikiPageUsesTemplate Template:Chemspidercite.
- Leptomycin wikiPageUsesTemplate Template:Citation_needed.
- Leptomycin wikiPageUsesTemplate Template:Gene.
- Leptomycin wikiPageUsesTemplate Template:MeshName.
- Leptomycin wikiPageUsesTemplate Template:Stdinchicite.
- Leptomycin subject Category:Antibiotics.
- Leptomycin hypernym Metabolite.
- Leptomycin type ChemicalCompound.
- Leptomycin type ChemicalSubstance.
- Leptomycin type Product.
- Leptomycin type ChemicalObject.
- Leptomycin type Thing.
- Leptomycin type Q11173.
- Leptomycin comment "Leptomycin B is a secondary metabolite produced by Streptomyces spp.Leptomycin B (LMB) was originally discovered as a potent anti-fungal antibiotic. Leptomycin B was found to cause cell elongation of the fission yeast Schizosaccharomyces pombe. Since then this elongation effect has been used for the bioassay of leptomycin.".
- Leptomycin label "Leptomycin".
- Leptomycin sameAs Q6528191.
- Leptomycin sameAs لپتومایسین.
- Leptomycin sameAs m.0btzvx.
- Leptomycin sameAs Leptomicin.
- Leptomycin sameAs Leptomicin.
- Leptomycin sameAs Q6528191.
- Leptomycin wasDerivedFrom Leptomycin?oldid=678945682.
- Leptomycin depiction Leptomycin_B.svg.
- Leptomycin isPrimaryTopicOf Leptomycin.