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- Leonard_R._Stephens abstract "Leonard (Len) R Stephens FRS (born 18 June 1960) is a molecular biologist, senior group leader and associate director at the Babraham Institute.Len Stephens has contributed much to the understanding of inositol lipids functions in eukaryotic cells, and in particular in neutrophils. Early highlights were the mapping of new pathways of inositol phosphate synthesis.Together with his long-time collaborator Phillip Thomas Hawkins, he established that PtdIns(4,5)P2 is the main substrate of receptor-controlled Type 1 phosphoinositide 3-kinases (PI3Ks), thus identifying PtdIns(3,4,5)P3 as the key output signal produced by this enzyme.They identified and isolated the GPCR-activated Type 1B PI3K (PI3KΥ) and, in a sustained body of work, defined its structure, explained its complex pattern of regulation by GβΥ and Ras, and proved its role in inflammatory events in vivo.They – in parallel with Dario Alessi – identified phosphoinositide-dependent kinase-1 as the PtdIns(3,4,5)P3-activated link between PI3K-1 activation and protein kinase B activation, a key pathway through which PtdIns(3,4,5)P3 formation regulates cell proliferation and survival. Later, they showed that PtdIns(3,4,5)P3 was responsible for the recruitment of both PKB and PDK1 to the membrane, and therefore the activation of the former by the latter.".
- Leonard_R._Stephens alias "Stephens, Len".
- Leonard_R._Stephens almaMater University_of_Birmingham.
- Leonard_R._Stephens birthDate "1960-06-18".
- Leonard_R._Stephens birthYear "1960".
- Leonard_R._Stephens field Immunology.
- Leonard_R._Stephens field Signal_transduction.
- Leonard_R._Stephens nationality United_Kingdom.
- Leonard_R._Stephens residence United_Kingdom.
- Leonard_R._Stephens wikiPageExternalLink stephens.
- Leonard_R._Stephens wikiPageID "41644229".
- Leonard_R._Stephens wikiPageLength "5744".
- Leonard_R._Stephens wikiPageOutDegree "39".
- Leonard_R._Stephens wikiPageRevisionID "702013314".
- Leonard_R._Stephens wikiPageWikiLink Babraham_Institute.
- Leonard_R._Stephens wikiPageWikiLink Bachelor_of_Science.
- Leonard_R._Stephens wikiPageWikiLink Biology.
- Leonard_R._Stephens wikiPageWikiLink Category:1960_births.
- Leonard_R._Stephens wikiPageWikiLink Category:Academics_of_the_University_of_Cambridge.
- Leonard_R._Stephens wikiPageWikiLink Category:Alumni_of_the_University_of_Birmingham.
- Leonard_R._Stephens wikiPageWikiLink Category:British_molecular_biologists.
- Leonard_R._Stephens wikiPageWikiLink Category:Fellows_of_the_Royal_Society.
- Leonard_R._Stephens wikiPageWikiLink Category:Living_people.
- Leonard_R._Stephens wikiPageWikiLink Category:Members_of_the_European_Molecular_Biology_Organization.
- Leonard_R._Stephens wikiPageWikiLink Cell_growth.
- Leonard_R._Stephens wikiPageWikiLink Dario_Alessi.
- Leonard_R._Stephens wikiPageWikiLink Doctor_of_Philosophy.
- Leonard_R._Stephens wikiPageWikiLink European_Molecular_Biology_Organization.
- Leonard_R._Stephens wikiPageWikiLink G_protein–coupled_receptor.
- Leonard_R._Stephens wikiPageWikiLink Immunology.
- Leonard_R._Stephens wikiPageWikiLink Inflammation.
- Leonard_R._Stephens wikiPageWikiLink Molecular_biology.
- Leonard_R._Stephens wikiPageWikiLink Neutrophil_granulocyte.
- Leonard_R._Stephens wikiPageWikiLink Phillip_Thomas_Hawkins.
- Leonard_R._Stephens wikiPageWikiLink Phosphatidylinositol.
- Leonard_R._Stephens wikiPageWikiLink Phosphatidylinositol_(3,4,5)-trisphosphate.
- Leonard_R._Stephens wikiPageWikiLink Phosphatidylinositol_4,5-bisphosphate.
- Leonard_R._Stephens wikiPageWikiLink Phosphoinositide-dependent_kinase-1.
- Leonard_R._Stephens wikiPageWikiLink Phosphoinositide_3-kinase.
- Leonard_R._Stephens wikiPageWikiLink Physiology.
- Leonard_R._Stephens wikiPageWikiLink Protein_kinase_B.
- Leonard_R._Stephens wikiPageWikiLink Ras_subfamily.
- Leonard_R._Stephens wikiPageWikiLink Royal_Society.
- Leonard_R._Stephens wikiPageWikiLink Signal_transduction.
- Leonard_R._Stephens wikiPageWikiLink United_Kingdom.
- Leonard_R._Stephens wikiPageWikiLink University_of_Birmingham.
- Leonard_R._Stephens wikiPageWikiLinkText "Leonard R. Stephens".
- Leonard_R._Stephens wikiPageWikiLinkText "Leonard Robert Stephens".
- Leonard_R._Stephens almaMater University_of_Birmingham.
- Leonard_R._Stephens alternativeNames "Stephens, Len".
- Leonard_R._Stephens dateOfBirth "1960-06-18".
- Leonard_R._Stephens field Immunology.
- Leonard_R._Stephens field Signal_transduction.
- Leonard_R._Stephens name "Len Stephens".
- Leonard_R._Stephens name "Stephens, Leonard R".
- Leonard_R._Stephens nationality United_Kingdom.
- Leonard_R._Stephens residence United_Kingdom.
- Leonard_R._Stephens shortDescription "British scientist".
- Leonard_R._Stephens wikiPageUsesTemplate Template:Infobox_scientist.
- Leonard_R._Stephens wikiPageUsesTemplate Template:Persondata.
- Leonard_R._Stephens wikiPageUsesTemplate Template:Reflist.
- Leonard_R._Stephens workInstitutions Babraham_Institute.
- Leonard_R._Stephens description "British scientist".
- Leonard_R._Stephens description "British scientist".
- Leonard_R._Stephens subject Category:1960_births.
- Leonard_R._Stephens subject Category:Academics_of_the_University_of_Cambridge.
- Leonard_R._Stephens subject Category:Alumni_of_the_University_of_Birmingham.
- Leonard_R._Stephens subject Category:British_molecular_biologists.
- Leonard_R._Stephens subject Category:Fellows_of_the_Royal_Society.
- Leonard_R._Stephens subject Category:Living_people.
- Leonard_R._Stephens subject Category:Members_of_the_European_Molecular_Biology_Organization.
- Leonard_R._Stephens hypernym Biologist.
- Leonard_R._Stephens type Agent.
- Leonard_R._Stephens type Person.
- Leonard_R._Stephens type Scientist.
- Leonard_R._Stephens type Person.
- Leonard_R._Stephens type Agent.
- Leonard_R._Stephens type NaturalPerson.
- Leonard_R._Stephens type Thing.
- Leonard_R._Stephens type Q215627.
- Leonard_R._Stephens type Q5.
- Leonard_R._Stephens type Q901.
- Leonard_R._Stephens type Person.
- Leonard_R._Stephens comment "Leonard (Len) R Stephens FRS (born 18 June 1960) is a molecular biologist, senior group leader and associate director at the Babraham Institute.Len Stephens has contributed much to the understanding of inositol lipids functions in eukaryotic cells, and in particular in neutrophils.".
- Leonard_R._Stephens label "Leonard R. Stephens".
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- Leonard_R._Stephens sameAs Q15994767.
- Leonard_R._Stephens wasDerivedFrom Leonard_R._Stephens?oldid=702013314.
- Leonard_R._Stephens givenName "Leonard R".
- Leonard_R._Stephens isPrimaryTopicOf Leonard_R._Stephens.
- Leonard_R._Stephens name "Len Stephens".
- Leonard_R._Stephens name "Leonard R Stephens".
- Leonard_R._Stephens name "Stephens, Leonard R".
- Leonard_R._Stephens surname "Stephens".