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- Laminin,_gamma_2 abstract "Laminin subunit gamma-2 is a protein that in humans is encoded by the LAMC2 gene.Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene.Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized".
- Laminin,_gamma_2 entrezgene "3918".
- Laminin,_gamma_2 wikiPageID "14725794".
- Laminin,_gamma_2 wikiPageLength "9402".
- Laminin,_gamma_2 wikiPageOutDegree "2".
- Laminin,_gamma_2 wikiPageRevisionID "678943679".
- Laminin,_gamma_2 wikiPageWikiLink Gene.
- Laminin,_gamma_2 wikiPageWikiLink Protein.
- Laminin,_gamma_2 wikiPageWikiLinkText "Lamc2".
- Laminin,_gamma_2 wikiPageWikiLinkText "Laminin, gamma 2".
- Laminin,_gamma_2 requireManualInspection "no".
- Laminin,_gamma_2 summaryText "Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain , is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 , which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized".
- Laminin,_gamma_2 updateCitations "yes".
- Laminin,_gamma_2 updatePage "yes".
- Laminin,_gamma_2 updateProteinBox "yes".
- Laminin,_gamma_2 updateSummary "yes".
- Laminin,_gamma_2 wikiPageUsesTemplate Template:Cite_journal.
- Laminin,_gamma_2 wikiPageUsesTemplate Template:Fibrous_proteins.
- Laminin,_gamma_2 wikiPageUsesTemplate Template:Gene-1-stub.
- Laminin,_gamma_2 wikiPageUsesTemplate Template:PBB.
- Laminin,_gamma_2 wikiPageUsesTemplate Template:PBB_Controls.
- Laminin,_gamma_2 wikiPageUsesTemplate Template:PBB_Further_reading.
- Laminin,_gamma_2 wikiPageUsesTemplate Template:PBB_Summary.
- Laminin,_gamma_2 wikiPageUsesTemplate Template:Refbegin.
- Laminin,_gamma_2 wikiPageUsesTemplate Template:Refend.
- Laminin,_gamma_2 wikiPageUsesTemplate Template:Reflist.
- Laminin,_gamma_2 hypernym Protein.
- Laminin,_gamma_2 type Biomolecule.
- Laminin,_gamma_2 type Protein.
- Laminin,_gamma_2 type Thing.
- Laminin,_gamma_2 type Q206229.
- Laminin,_gamma_2 type Q8054.
- Laminin,_gamma_2 comment "Laminin subunit gamma-2 is a protein that in humans is encoded by the LAMC2 gene.Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis.".
- Laminin,_gamma_2 label "Laminin, gamma 2".
- Laminin,_gamma_2 sameAs Q18028466.
- Laminin,_gamma_2 sameAs m.03gvpb0.
- Laminin,_gamma_2 sameAs Q18028466.
- Laminin,_gamma_2 wasDerivedFrom Laminin,_gamma_2?oldid=678943679.
- Laminin,_gamma_2 isPrimaryTopicOf Laminin,_gamma_2.