Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Lacritin> ?p ?o }
- Lacritin abstract "Lacritin is a 12.3 kDa glycoprotein encoded in humans by the LACRT gene. Lacritin's discovery emerged from an unbiased screen for novel factors that stimulate tear protein secretion. Lacritin is a secreted protein found in tears and saliva. Lacritin also promotes tear secretion, the proliferation and survival of epithelial cells, and corneal wound healing Lacritin is thus a multifunctional prosecretory mitogen with cell survival activity. Natural or bacterial cleavage of lacritin releases a C-terminal fragment that is bactericidal.Most lacritin is produced by the lacrimal gland, including the accessory lacrimal gland of Wolfring. Some lacritin is produced by the meibomian gland, and by epithelial cells of the conjunctiva and cornea. Together these epithelia comprise much of the lacrimal functional unit (LFU). Dry eye is the most common disease of the LFU. A growing number of studies suggest that lacritin may be differentially downregulated in dry eye, including contact lens-related dry eye. Topical lacritin promotes tearing in rabbit preclinical studies. In the Aire knockout mouse model of dry eye (considered similar to human Sjogren's syndrome), topical lacritin restores pilocarpine-induced tearing, largely eliminates lissamine green staining and reduces the size of inflammatory foci in the lacrimal gland.Lacritin cell targeting is dependent on the cell surface heparan sulfate proteoglycan syndecan-1 (SDC1). Binding utilizes an enzyme-regulated 'off-on' switch in which active epithelial heparanase (HPSE) cleaves off heparan sulfate to expose a binding site in the N-terminal region of syndecan-1's core protein. A G-protein-coupled receptor (GPCR) then appears to be ligated. Targeted cells signal to NFAT and mTOR if conditions are suitable for proliferation, or to AKT and FOXO3 under conditions of stress.".
- Lacritin entrezgene "90070".
- Lacritin wikiPageExternalLink Home.html.
- Lacritin wikiPageExternalLink 90070.html.
- Lacritin wikiPageExternalLink V35N6p400.pdf.
- Lacritin wikiPageExternalLink a36.
- Lacritin wikiPageID "5923905".
- Lacritin wikiPageLength "40297".
- Lacritin wikiPageOutDegree "99".
- Lacritin wikiPageRevisionID "696268795".
- Lacritin wikiPageWikiLink Alpha_helix.
- Lacritin wikiPageWikiLink Alternative_splicing.
- Lacritin wikiPageWikiLink Amino_acid.
- Lacritin wikiPageWikiLink Amphiphile.
- Lacritin wikiPageWikiLink Blepharitis.
- Lacritin wikiPageWikiLink Breast_cancer.
- Lacritin wikiPageWikiLink Calcineurin.
- Lacritin wikiPageWikiLink Category:Glycoproteins.
- Lacritin wikiPageWikiLink Cell_growth.
- Lacritin wikiPageWikiLink Chondroitin_sulfate.
- Lacritin wikiPageWikiLink Climatic_droplet_keratopathy.
- Lacritin wikiPageWikiLink Conjunctiva.
- Lacritin wikiPageWikiLink Cornea.
- Lacritin wikiPageWikiLink Duct_(anatomy).
- Lacritin wikiPageWikiLink Ensembl.
- Lacritin wikiPageWikiLink Epithelium.
- Lacritin wikiPageWikiLink Eye_disease.
- Lacritin wikiPageWikiLink G_protein–coupled_receptor.
- Lacritin wikiPageWikiLink Gene.
- Lacritin wikiPageWikiLink Germ_cell.
- Lacritin wikiPageWikiLink Gi_alpha_subunit.
- Lacritin wikiPageWikiLink Glycoprotein.
- Lacritin wikiPageWikiLink Glycosylation.
- Lacritin wikiPageWikiLink Growth_factor.
- Lacritin wikiPageWikiLink Heparan_sulfate.
- Lacritin wikiPageWikiLink Heparanase.
- Lacritin wikiPageWikiLink Human_eye.
- Lacritin wikiPageWikiLink Hydrophile.
- Lacritin wikiPageWikiLink Hydrophobe.
- Lacritin wikiPageWikiLink Keratoconjunctivitis_sicca.
- Lacritin wikiPageWikiLink LASIK.
- Lacritin wikiPageWikiLink Lacrimal_gland.
- Lacritin wikiPageWikiLink Lacritin.
- Lacritin wikiPageWikiLink Mammary_gland.
- Lacritin wikiPageWikiLink Mass_spectrometry.
- Lacritin wikiPageWikiLink Mechanistic_target_of_rapamycin.
- Lacritin wikiPageWikiLink Meibomian_gland.
- Lacritin wikiPageWikiLink Mitogen.
- Lacritin wikiPageWikiLink N-linked_glycosylation.
- Lacritin wikiPageWikiLink NEIBank.
- Lacritin wikiPageWikiLink NFAT.
- Lacritin wikiPageWikiLink NFATC1.
- Lacritin wikiPageWikiLink O-linked_glycosylation.
- Lacritin wikiPageWikiLink PKC_alpha.
- Lacritin wikiPageWikiLink PLCG2.
- Lacritin wikiPageWikiLink PONDR.
- Lacritin wikiPageWikiLink Pertussis_toxin.
- Lacritin wikiPageWikiLink Phospholipase_D1.
- Lacritin wikiPageWikiLink Photorefractive_keratectomy.
- Lacritin wikiPageWikiLink Protein_folding.
- Lacritin wikiPageWikiLink Proteoglycan.
- Lacritin wikiPageWikiLink Recombinant_DNA.
- Lacritin wikiPageWikiLink SDC2.
- Lacritin wikiPageWikiLink SDC4.
- Lacritin wikiPageWikiLink Saliva.
- Lacritin wikiPageWikiLink Salivary_gland.
- Lacritin wikiPageWikiLink Secretion.
- Lacritin wikiPageWikiLink Signal_peptide.
- Lacritin wikiPageWikiLink Small_interfering_RNA.
- Lacritin wikiPageWikiLink Syndecan_1.
- Lacritin wikiPageWikiLink Tears.
- Lacritin wikiPageWikiLink Thyroid.
- Lacritin wikiPageWikiLink Tissue_transglutaminase.
- Lacritin wikiPageWikiLink Unigene_Laboratories.
- Lacritin wikiPageWikiLinkText "Lacritin".
- Lacritin wikiPageWikiLinkText "lacritin".
- Lacritin abbrev "LACRT".
- Lacritin footnotes "Preclinical studies suggest utility in increasing ocular tearing".
- Lacritin name "Lacritin".
- Lacritin receptors "syndecan-1 as coreceptor; requires active heparanase to expose a protein core binding site; Signaling receptor: a GPCR is suspected ; Site of Binding: between N-terminus of SDC1 and C-terminus of lacritin; N-terminal site includes GAGAL, heparanase cleaved heparan 3-O sulfate stub and chondroitin sulfate".
- Lacritin sources "lacrimal, meibomian and salivary glands; corneal and conjunctival epithelia; lung lavage".
- Lacritin targets "epithelial specificity".
- Lacritin wikiPageUsesTemplate Template:Cite_journal.
- Lacritin wikiPageUsesTemplate Template:Cite_web.
- Lacritin wikiPageUsesTemplate Template:Infobox_neurotransmitter.
- Lacritin wikiPageUsesTemplate Template:MeshName.
- Lacritin wikiPageUsesTemplate Template:PBB.
- Lacritin wikiPageUsesTemplate Template:Refbegin.
- Lacritin wikiPageUsesTemplate Template:Refend.
- Lacritin wikiPageUsesTemplate Template:Reflist.
- Lacritin subject Category:Glycoproteins.
- Lacritin hypernym Glycoprotein.
- Lacritin type Biomolecule.
- Lacritin type Protein.
- Lacritin type Glycoprotein.
- Lacritin type Thing.
- Lacritin type Q206229.
- Lacritin type Q8054.
- Lacritin comment "Lacritin is a 12.3 kDa glycoprotein encoded in humans by the LACRT gene. Lacritin's discovery emerged from an unbiased screen for novel factors that stimulate tear protein secretion. Lacritin is a secreted protein found in tears and saliva. Lacritin also promotes tear secretion, the proliferation and survival of epithelial cells, and corneal wound healing Lacritin is thus a multifunctional prosecretory mitogen with cell survival activity.".
- Lacritin label "Lacritin".