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- LY-404,187 abstract "LY-404,187 (or LY404187) is an ampakine (or \"AMPA receptor potentiator\") developed by Eli Lilly and Company. It is a member of the biarylpropylsulfonamide class of ampakines.LY-404,187 has been demonstrated to enhance cognitive function in animal studies, and has also shown effects suggesting antidepressant action as well as having possible application in the treatment of schizophrenia, Parkinson's disease and ADHD. These effects appear to be mediated through multiple mechanisms of action secondary to AMPA receptor potentiation, with a prominent effect seen in research being increased levels of BDNF in the brain. It may therefore be continued on to human trials, although Eli Lilly has developed a whole family of biarylpropylsulfonamide derivatives and it is unclear at this stage which compound is most likely to be selected for further development.".
- LY-404,187 atcPrefix "none".
- LY-404,187 casNumber "211311-95-4".
- LY-404,187 iupacName "N-[2-(4'-cyanobiphenyl-4-yl)propyl]propane-2-sulfonamide".
- LY-404,187 thumbnail LY404187.png?width=300.
- LY-404,187 wikiPageID "18493882".
- LY-404,187 wikiPageLength "4879".
- LY-404,187 wikiPageOutDegree "12".
- LY-404,187 wikiPageRevisionID "636647147".
- LY-404,187 wikiPageWikiLink Ampakine.
- LY-404,187 wikiPageWikiLink Antidepressant.
- LY-404,187 wikiPageWikiLink Attention_deficit_hyperactivity_disorder.
- LY-404,187 wikiPageWikiLink Brain-derived_neurotrophic_factor.
- LY-404,187 wikiPageWikiLink Category:AMPA_receptor_agonists.
- LY-404,187 wikiPageWikiLink Category:Ampakines.
- LY-404,187 wikiPageWikiLink Category:Eli_Lilly_and_Company.
- LY-404,187 wikiPageWikiLink Category:Nitriles.
- LY-404,187 wikiPageWikiLink Category:Sulfonamides.
- LY-404,187 wikiPageWikiLink Eli_Lilly_and_Company.
- LY-404,187 wikiPageWikiLink Parkinsons_disease.
- LY-404,187 wikiPageWikiLink Schizophrenia.
- LY-404,187 wikiPageWikiLinkText "LY-404,187".
- LY-404,187 atcPrefix "none".
- LY-404,187 c "19".
- LY-404,187 casNumber "211311".
- LY-404,187 chemspiderid "18962921".
- LY-404,187 h "22".
- LY-404,187 inchi "1".
- LY-404,187 inchikey "AIALBPYHYGYYRB-UHFFFAOYAB".
- LY-404,187 iupacName "N-[2-propyl]propane-2-sulfonamide".
- LY-404,187 legalStatus "Investigational New Medicine".
- LY-404,187 molecularWeight "342.45".
- LY-404,187 n "2".
- LY-404,187 o "2".
- LY-404,187 s "1".
- LY-404,187 smiles "N#Cc2ccc-c1ccccc1".
- LY-404,187 stdinchi "1".
- LY-404,187 stdinchikey "AIALBPYHYGYYRB-UHFFFAOYSA-N".
- LY-404,187 synonyms "(LY-404,187; N-2-[4-phenyl]propyl-2-propanesulfonamide)".
- LY-404,187 verifiedfields "changed".
- LY-404,187 verifiedrevid "449869240".
- LY-404,187 watchedfields "changed".
- LY-404,187 width "200".
- LY-404,187 wikiPageUsesTemplate Template:Cascite.
- LY-404,187 wikiPageUsesTemplate Template:Chemspidercite.
- LY-404,187 wikiPageUsesTemplate Template:Drugbankcite.
- LY-404,187 wikiPageUsesTemplate Template:Drugbox.
- LY-404,187 wikiPageUsesTemplate Template:Glutamatergics.
- LY-404,187 wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- LY-404,187 wikiPageUsesTemplate Template:Nootropics.
- LY-404,187 wikiPageUsesTemplate Template:Reflist.
- LY-404,187 wikiPageUsesTemplate Template:Stdinchicite.
- LY-404,187 subject Category:AMPA_receptor_agonists.
- LY-404,187 subject Category:Ampakines.
- LY-404,187 subject Category:Eli_Lilly_and_Company.
- LY-404,187 subject Category:Nitriles.
- LY-404,187 subject Category:Sulfonamides.
- LY-404,187 hypernym Ampakine.
- LY-404,187 type ChemicalSubstance.
- LY-404,187 type Company.
- LY-404,187 type Drug.
- LY-404,187 type Group.
- LY-404,187 type Amide.
- LY-404,187 type Chemical.
- LY-404,187 type Company.
- LY-404,187 type Drug.
- LY-404,187 type Group.
- LY-404,187 type Modulator.
- LY-404,187 type Nitrile.
- LY-404,187 type Nootropic.
- LY-404,187 type Sulfonamide.
- LY-404,187 type ChemicalObject.
- LY-404,187 type Thing.
- LY-404,187 type Q8386.
- LY-404,187 comment "LY-404,187 (or LY404187) is an ampakine (or \"AMPA receptor potentiator\") developed by Eli Lilly and Company. It is a member of the biarylpropylsulfonamide class of ampakines.LY-404,187 has been demonstrated to enhance cognitive function in animal studies, and has also shown effects suggesting antidepressant action as well as having possible application in the treatment of schizophrenia, Parkinson's disease and ADHD.".
- LY-404,187 label "LY-404,187".
- LY-404,187 sameAs Q6460433.
- LY-404,187 sameAs m.04f1j_y.
- LY-404,187 sameAs LY-404,187.
- LY-404,187 sameAs LY-404,187.
- LY-404,187 sameAs Q6460433.
- LY-404,187 wasDerivedFrom LY-404,187?oldid=636647147.
- LY-404,187 depiction LY404187.png.
- LY-404,187 isPrimaryTopicOf LY-404,187.