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- LY-404,039 abstract "LY-404,039, also known as pomaglumetad, is an amino acid analog drug that acts as a highly selective agonist for the metabotropic glutamate receptor group II subtypes mGluR2 and mGluR3. Pharmacological research has focused on its potential antipsychotic and anxiolytic effects. LY-404,039 is intended as a treatment for schizophrenia and other psychotic and anxiety disorders by modulating glutamatergic activity and reducing presynaptic release of glutamate at synapses in limbic and forebrain areas relevant to these disorders. Human studies investigating therapeutic use of LY-404,039 have focused on the prodrug LY-2140023, a methionine amide of LY-404,039 (also called pomaglumetad methionil or LY-2140023 monohydrate) since LY-404,039 exhibits low oral absorption and bioavailability in humans.Early human trials using this prodrug form of LY-404,039 gave encouraging results. However, pharmaceutical company Eli Lilly terminated further development of the compound in 2012 after it failed in phase II clinical trials. In September 2013, the results of a randomized, placebo-controlled clinical trial investigating the impact of adjunctive LY-2140023 on prominent negative symptoms in schizophrenia was published and failed to demonstrate any benefit.".
- LY-404,039 atcPrefix "N".
- LY-404,039 iupacName "(−)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid".
- LY-404,039 pubchem "9834591".
- LY-404,039 thumbnail LY404039_structure.png?width=300.
- LY-404,039 wikiPageID "23624907".
- LY-404,039 wikiPageLength "30871".
- LY-404,039 wikiPageOutDegree "37".
- LY-404,039 wikiPageRevisionID "686978899".
- LY-404,039 wikiPageWikiLink 3,4-Dihydroxyphenylacetic_acid.
- LY-404,039 wikiPageWikiLink 5-Hydroxyindoleacetic_acid.
- LY-404,039 wikiPageWikiLink Anxiolytic.
- LY-404,039 wikiPageWikiLink Aripiprazole.
- LY-404,039 wikiPageWikiLink AstraZeneca.
- LY-404,039 wikiPageWikiLink Category:MGlu2_receptor_agonists.
- LY-404,039 wikiPageWikiLink Category:MGlu3_receptor_agonists.
- LY-404,039 wikiPageWikiLink Category:Schizophrenia.
- LY-404,039 wikiPageWikiLink Clinical_Global_Impression.
- LY-404,039 wikiPageWikiLink Clinical_trial.
- LY-404,039 wikiPageWikiLink Clozapine.
- LY-404,039 wikiPageWikiLink Cyclic_adenosine_monophosphate.
- LY-404,039 wikiPageWikiLink Domperidone.
- LY-404,039 wikiPageWikiLink Eli_Lilly_and_Company.
- LY-404,039 wikiPageWikiLink Excitatory_postsynaptic_potential.
- LY-404,039 wikiPageWikiLink Forskolin.
- LY-404,039 wikiPageWikiLink Gamma-Aminobutyric_acid.
- LY-404,039 wikiPageWikiLink Glutamate_hypothesis_of_schizophrenia.
- LY-404,039 wikiPageWikiLink Glutamic_acid.
- LY-404,039 wikiPageWikiLink Homovanillic_acid.
- LY-404,039 wikiPageWikiLink Kainate_receptor.
- LY-404,039 wikiPageWikiLink LY-341,495.
- LY-404,039 wikiPageWikiLink LY-379,268.
- LY-404,039 wikiPageWikiLink Metabotropic_glutamate_receptor.
- LY-404,039 wikiPageWikiLink Metabotropic_glutamate_receptor_2.
- LY-404,039 wikiPageWikiLink Metabotropic_glutamate_receptor_3.
- LY-404,039 wikiPageWikiLink Methionine.
- LY-404,039 wikiPageWikiLink NMDA_receptor.
- LY-404,039 wikiPageWikiLink Olanzapine.
- LY-404,039 wikiPageWikiLink Peptide_transporter_1.
- LY-404,039 wikiPageWikiLink Pomaglumetad_methionil.
- LY-404,039 wikiPageWikiLink Positive_and_Negative_Syndrome_Scale.
- LY-404,039 wikiPageWikiLink Risperidone.
- LY-404,039 wikiPageWikiLink Schizophrenia.
- LY-404,039 wikiPageWikiLink Serotonin.
- LY-404,039 wikiPageWikiLink Talaglumetad.
- LY-404,039 wikiPageWikiLink File:LY2140023_structure.png.
- LY-404,039 wikiPageWikiLinkText "LY-404,039".
- LY-404,039 atcPrefix "N".
- LY-404,039 c "7".
- LY-404,039 chemspiderid "8010312".
- LY-404,039 h "9".
- LY-404,039 inchi "1".
- LY-404,039 inchikey "AVDUGNCTZRCAHH-MDASVERJBY".
- LY-404,039 iupacName "--4-amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic acid".
- LY-404,039 legalStatus "Not FDA-Approved".
- LY-404,039 molecularWeight "235.214".
- LY-404,039 n "1".
- LY-404,039 o "6".
- LY-404,039 pubchem "9834591".
- LY-404,039 s "1".
- LY-404,039 smiles "C1[C@]N".
- LY-404,039 stdinchi "1".
- LY-404,039 stdinchikey "AVDUGNCTZRCAHH-MDASVERJSA-N".
- LY-404,039 verifiedfields "changed".
- LY-404,039 verifiedrevid "447658602".
- LY-404,039 watchedfields "changed".
- LY-404,039 width "200".
- LY-404,039 wikiPageUsesTemplate Template:Cascite.
- LY-404,039 wikiPageUsesTemplate Template:Chemspidercite.
- LY-404,039 wikiPageUsesTemplate Template:Drugbankcite.
- LY-404,039 wikiPageUsesTemplate Template:Drugbox.
- LY-404,039 wikiPageUsesTemplate Template:Glutamatergics.
- LY-404,039 wikiPageUsesTemplate Template:Reflist.
- LY-404,039 wikiPageUsesTemplate Template:Stdinchicite.
- LY-404,039 wikiPageUsesTemplate Template:Sub.
- LY-404,039 subject Category:MGlu2_receptor_agonists.
- LY-404,039 subject Category:MGlu3_receptor_agonists.
- LY-404,039 subject Category:Schizophrenia.
- LY-404,039 hypernym Drug.
- LY-404,039 type ChemicalSubstance.
- LY-404,039 type Company.
- LY-404,039 type Drug.
- LY-404,039 type Chemical.
- LY-404,039 type Company.
- LY-404,039 type Drug.
- LY-404,039 type ChemicalObject.
- LY-404,039 type Thing.
- LY-404,039 type Q8386.
- LY-404,039 comment "LY-404,039, also known as pomaglumetad, is an amino acid analog drug that acts as a highly selective agonist for the metabotropic glutamate receptor group II subtypes mGluR2 and mGluR3. Pharmacological research has focused on its potential antipsychotic and anxiolytic effects.".
- LY-404,039 label "LY-404,039".
- LY-404,039 sameAs Q6460431.
- LY-404,039 sameAs m.06zkyqc.
- LY-404,039 sameAs LY-404,039.
- LY-404,039 sameAs LY-404,039.
- LY-404,039 sameAs Q6460431.
- LY-404,039 wasDerivedFrom LY-404,039?oldid=686978899.
- LY-404,039 depiction LY404039_structure.png.
- LY-404,039 isPrimaryTopicOf LY-404,039.