Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/LM22A-4> ?p ?o }
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- LM22A-4 abstract "LM22A-4 is a synthetic, selective small-molecule partial agonist of TrkB (EC50 for TrkB activation = 200–500 pM; IC50 for inhibition of BDNF binding to TrkB = 47 nM; IA = ~85%), the main receptor of brain-derived neurotrophic factor. It has been found to possess poor blood-brain-barrier penetration when administered systemically, so LM22A-4 has been given to animals instead via intranasal administration, with central nervous system TrkB activation observed. The compound produces neurogenic and neuroprotective effects in animals, and shows beneficial effects on respiration in animal models of Rett syndrome.".
- LM22A-4 atcPrefix "None".
- LM22A-4 casNumber "37988-18-4".
- LM22A-4 iupacName "1-N,3-N,5-N-tris(2-Hydroxyethyl)benzene-1,3,5-tricarboxamide".
- LM22A-4 pubchem "2054170".
- LM22A-4 thumbnail LM22A-4_structure.svg?width=300.
- LM22A-4 wikiPageID "49040200".
- LM22A-4 wikiPageLength "5263".
- LM22A-4 wikiPageOutDegree "28".
- LM22A-4 wikiPageRevisionID "699549894".
- LM22A-4 wikiPageWikiLink 7,8-Dihydroxyflavone.
- LM22A-4 wikiPageWikiLink ANA-12.
- LM22A-4 wikiPageWikiLink Blood–brain_barrier.
- LM22A-4 wikiPageWikiLink Brain-derived_neurotrophic_factor.
- LM22A-4 wikiPageWikiLink Category:Carboxamides.
- LM22A-4 wikiPageWikiLink Category:Neuroprotective_agents.
- LM22A-4 wikiPageWikiLink Category:Nootropics.
- LM22A-4 wikiPageWikiLink Category:TrkB_agonists.
- LM22A-4 wikiPageWikiLink Central_nervous_system.
- LM22A-4 wikiPageWikiLink Cyclotraxin_B.
- LM22A-4 wikiPageWikiLink Deoxygedunin.
- LM22A-4 wikiPageWikiLink EC50.
- LM22A-4 wikiPageWikiLink HIOC.
- LM22A-4 wikiPageWikiLink IC50.
- LM22A-4 wikiPageWikiLink Intrinsic_activity.
- LM22A-4 wikiPageWikiLink K252a.
- LM22A-4 wikiPageWikiLink Model_organism.
- LM22A-4 wikiPageWikiLink N-Acetylserotonin.
- LM22A-4 wikiPageWikiLink Nasal_administration.
- LM22A-4 wikiPageWikiLink Nervous_system.
- LM22A-4 wikiPageWikiLink Neuroprotection.
- LM22A-4 wikiPageWikiLink Organic_compound.
- LM22A-4 wikiPageWikiLink Partial_agonist.
- LM22A-4 wikiPageWikiLink Receptor_(biochemistry).
- LM22A-4 wikiPageWikiLink Respiration_(physiology).
- LM22A-4 wikiPageWikiLink Rett_syndrome.
- LM22A-4 wikiPageWikiLink Small_molecule.
- LM22A-4 wikiPageWikiLink Tropomyosin_receptor_kinase_B.
- LM22A-4 wikiPageWikiLinkText "LM22A-4".
- LM22A-4 atcPrefix "None".
- LM22A-4 c "15".
- LM22A-4 casNumber "37988".
- LM22A-4 chemspiderid "1548402".
- LM22A-4 h "21".
- LM22A-4 inchi "InChI=1S/C15H21N3O6/c19-4-1-16-1310-7-119-121518-3-6-21/h7-9,19-21H,1-6H2,".
- LM22A-4 inchikey "RGWJKANXFYJKHN-UHFFFAOYSA-N".
- LM22A-4 iupacName "1".
- LM22A-4 molecularWeight "339.34374".
- LM22A-4 n "3".
- LM22A-4 o "6".
- LM22A-4 pubchem "2054170".
- LM22A-4 smiles "C1=CCNCCO".
- LM22A-4 stdinchi "1".
- LM22A-4 stdinchikey "RGWJKANXFYJKHN-UHFFFAOYSA-N".
- LM22A-4 wikiPageUsesTemplate Template:Drugbox.
- LM22A-4 wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- LM22A-4 wikiPageUsesTemplate Template:Neurotrophinergics.
- LM22A-4 wikiPageUsesTemplate Template:Reflist.
- LM22A-4 subject Category:Carboxamides.
- LM22A-4 subject Category:Neuroprotective_agents.
- LM22A-4 subject Category:Nootropics.
- LM22A-4 subject Category:TrkB_agonists.
- LM22A-4 hypernym Agonist.
- LM22A-4 type ChemicalSubstance.
- LM22A-4 type Drug.
- LM22A-4 type ChemicalObject.
- LM22A-4 type Thing.
- LM22A-4 type Q8386.
- LM22A-4 comment "LM22A-4 is a synthetic, selective small-molecule partial agonist of TrkB (EC50 for TrkB activation = 200–500 pM; IC50 for inhibition of BDNF binding to TrkB = 47 nM; IA = ~85%), the main receptor of brain-derived neurotrophic factor. It has been found to possess poor blood-brain-barrier penetration when administered systemically, so LM22A-4 has been given to animals instead via intranasal administration, with central nervous system TrkB activation observed.".
- LM22A-4 label "LM22A-4".
- LM22A-4 wasDerivedFrom LM22A-4?oldid=699549894.
- LM22A-4 depiction LM22A-4_structure.svg.
- LM22A-4 isPrimaryTopicOf LM22A-4.