Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/L-733,060> ?p ?o }
- L-733,060 abstract "L-733,060 is a drug developed by Merck, Sharpe & Dohme which acts as an orally active, non-peptide, selective antagonist for the NK1 receptor, binding with a Ki of 0.08nM. Only one enantiomer is active which has made it the subject of several asymmetric synthesis efforts.L-733,060 has antidepressant and anxiolytic effects in animal studies, and reduces both the dopamine release and neurotoxicity produced by methamphetamine and cocaine. It shows antiinflammatory and anti-hepatotoxic effects in animals, and counteracts the development of hyperalgesia following nerve injury. It also has anticancer effects in a variety of in vitro models.".
- L-733,060 casNumber "148700-85-0".
- L-733,060 iupacName "(2S,3S)-3-{[3,5-bis(trifluoromethyl)benzyl]oxy}-2-phenylpiperidine".
- L-733,060 pubchem "132846".
- L-733,060 thumbnail L-733,060_structure.png?width=300.
- L-733,060 wikiPageID "20233517".
- L-733,060 wikiPageLength "12759".
- L-733,060 wikiPageOutDegree "29".
- L-733,060 wikiPageRevisionID "704278335".
- L-733,060 wikiPageWikiLink Anti-inflammatory.
- L-733,060 wikiPageWikiLink Anticarcinogen.
- L-733,060 wikiPageWikiLink Antidepressant.
- L-733,060 wikiPageWikiLink Anxiolytic.
- L-733,060 wikiPageWikiLink Aprepitant.
- L-733,060 wikiPageWikiLink Casopitant.
- L-733,060 wikiPageWikiLink Category:Antidepressants.
- L-733,060 wikiPageWikiLink Category:Anxiolytics.
- L-733,060 wikiPageWikiLink Category:Ethers.
- L-733,060 wikiPageWikiLink Category:NK1_receptor_antagonists.
- L-733,060 wikiPageWikiLink Category:Organofluorides.
- L-733,060 wikiPageWikiLink Category:Piperidines.
- L-733,060 wikiPageWikiLink Cocaine.
- L-733,060 wikiPageWikiLink Dissociation_constant.
- L-733,060 wikiPageWikiLink Dopamine.
- L-733,060 wikiPageWikiLink Enantiomer.
- L-733,060 wikiPageWikiLink Enantioselective_synthesis.
- L-733,060 wikiPageWikiLink Fosaprepitant.
- L-733,060 wikiPageWikiLink Hepatotoxicity.
- L-733,060 wikiPageWikiLink Hyperalgesia.
- L-733,060 wikiPageWikiLink Maropitant.
- L-733,060 wikiPageWikiLink Merck_&_Co..
- L-733,060 wikiPageWikiLink Methamphetamine.
- L-733,060 wikiPageWikiLink Neurotoxicity.
- L-733,060 wikiPageWikiLink Receptor_(biochemistry).
- L-733,060 wikiPageWikiLink Receptor_antagonist.
- L-733,060 wikiPageWikiLink Tachykinin_receptor_1.
- L-733,060 wikiPageWikiLink Vestipitant.
- L-733,060 wikiPageWikiLink Vofopitant.
- L-733,060 wikiPageWikiLinkText "L-733,060".
- L-733,060 c "20".
- L-733,060 casNumber "148700".
- L-733,060 chembl "27006".
- L-733,060 chemspiderid "117244".
- L-733,060 f "6".
- L-733,060 h "19".
- L-733,060 inchi "1".
- L-733,060 inchikey "FCDRFVCGMLUYPG-ROUUACIJBF".
- L-733,060 iupacName "-3".
- L-733,060 molecularWeight "403.361".
- L-733,060 n "1".
- L-733,060 o "1".
- L-733,060 pubchem "132846".
- L-733,060 smiles "c1ccc[C@H]2[C@H]OCc3ccCF".
- L-733,060 stdinchi "1".
- L-733,060 stdinchikey "FCDRFVCGMLUYPG-ROUUACIJSA-N".
- L-733,060 verifiedfields "changed".
- L-733,060 verifiedrevid "438696640".
- L-733,060 watchedfields "changed".
- L-733,060 width "220".
- L-733,060 wikiPageUsesTemplate Template:Antidepressants.
- L-733,060 wikiPageUsesTemplate Template:Antiemetics_and_antinauseants.
- L-733,060 wikiPageUsesTemplate Template:Anxiolytics.
- L-733,060 wikiPageUsesTemplate Template:Cascite.
- L-733,060 wikiPageUsesTemplate Template:Chemspidercite.
- L-733,060 wikiPageUsesTemplate Template:Colbegin.
- L-733,060 wikiPageUsesTemplate Template:Colend.
- L-733,060 wikiPageUsesTemplate Template:Drugbankcite.
- L-733,060 wikiPageUsesTemplate Template:Drugbox.
- L-733,060 wikiPageUsesTemplate Template:Ebicite.
- L-733,060 wikiPageUsesTemplate Template:Neuropeptide_agonists_and_antagonists.
- L-733,060 wikiPageUsesTemplate Template:Reflist.
- L-733,060 wikiPageUsesTemplate Template:Stdinchicite.
- L-733,060 subject Category:Antidepressants.
- L-733,060 subject Category:Anxiolytics.
- L-733,060 subject Category:Ethers.
- L-733,060 subject Category:NK1_receptor_antagonists.
- L-733,060 subject Category:Organofluorides.
- L-733,060 subject Category:Piperidines.
- L-733,060 hypernym Drug.
- L-733,060 type ChemicalSubstance.
- L-733,060 type Drug.
- L-733,060 type Group.
- L-733,060 type Antagonist.
- L-733,060 type Antidepressant.
- L-733,060 type Chemical.
- L-733,060 type Drug.
- L-733,060 type Ether.
- L-733,060 type Group.
- L-733,060 type Heterocycle.
- L-733,060 type Organofluoride.
- L-733,060 type Organohalide.
- L-733,060 type Psychoanaleptic.
- L-733,060 type Organofluoride.
- L-733,060 type Organohalide.
- L-733,060 type ChemicalObject.
- L-733,060 type Thing.
- L-733,060 type Q8386.
- L-733,060 comment "L-733,060 is a drug developed by Merck, Sharpe & Dohme which acts as an orally active, non-peptide, selective antagonist for the NK1 receptor, binding with a Ki of 0.08nM. Only one enantiomer is active which has made it the subject of several asymmetric synthesis efforts.L-733,060 has antidepressant and anxiolytic effects in animal studies, and reduces both the dopamine release and neurotoxicity produced by methamphetamine and cocaine.".
- L-733,060 label "L-733,060".
- L-733,060 sameAs Q6456079.