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- L-368,899 abstract "L-368,899 is a drug used in scientific research which acts as a selective antagonist of the oxytocin receptor, with good selectivity over the related vasopressin receptors. Unlike related drugs such as the peripherally selective L-371,257, the oral bioavailabity is high and the brain penetration of L-368,899 is rapid, with selective accumulation in areas of the limbic system. This makes it a useful tool for investigating the centrally mediated roles of oxytocin, such as in social behaviour and pair bonding, and studies in primates have shown L-368,899 to reduce a number of behaviours such as food sharing, sexual activity and caring for infants, demonstrating the importance of oxytocinergic signalling in mediating these important social behaviours.".
- L-368,899 casNumber "148927-60-0".
- L-368,899 iupacName "(S)-2-amino-N-((1S,2S,4R)-7,7-dimethyl-1-((4-o-tolylpiperazin-1-ylsulfonyl)methyl)bicyclo[2.2.1]heptan-2-yl)-4-(methylsulfonyl)butanamide".
- L-368,899 pubchem "132857".
- L-368,899 thumbnail L-368,899_structure.png?width=300.
- L-368,899 wikiPageID "31475159".
- L-368,899 wikiPageLength "3812".
- L-368,899 wikiPageOutDegree "12".
- L-368,899 wikiPageRevisionID "667226345".
- L-368,899 wikiPageWikiLink Atosiban.
- L-368,899 wikiPageWikiLink Barusiban.
- L-368,899 wikiPageWikiLink Category:Oxytocin_receptor_antagonists.
- L-368,899 wikiPageWikiLink Category:Tocolytics.
- L-368,899 wikiPageWikiLink Epelsiban.
- L-368,899 wikiPageWikiLink L-371,257.
- L-368,899 wikiPageWikiLink Limbic_system.
- L-368,899 wikiPageWikiLink Oxytocin_receptor.
- L-368,899 wikiPageWikiLink Receptor_antagonist.
- L-368,899 wikiPageWikiLink Retosiban.
- L-368,899 wikiPageWikiLink Vasopressin_receptor.
- L-368,899 wikiPageWikiLinkText "L-368,899".
- L-368,899 c "26".
- L-368,899 casNumber "148927".
- L-368,899 h "42".
- L-368,899 iupacName "-2".
- L-368,899 iupharLigand "2249".
- L-368,899 molecularWeight "554.26".
- L-368,899 n "4".
- L-368,899 o "5".
- L-368,899 pubchem "132857".
- L-368,899 s "2".
- L-368,899 smiles "CC1[C@@]2CC[C@@H]1C[C@@H]2NC=O".
- L-368,899 verifiedrevid "451607732".
- L-368,899 width "240".
- L-368,899 wikiPageUsesTemplate Template:Cascite.
- L-368,899 wikiPageUsesTemplate Template:Drugbankcite.
- L-368,899 wikiPageUsesTemplate Template:Drugbox.
- L-368,899 wikiPageUsesTemplate Template:Neuropeptidergics.
- L-368,899 wikiPageUsesTemplate Template:Reflist.
- L-368,899 wikiPageUsesTemplate Template:Systemic-hormonal-drug-stub.
- L-368,899 subject Category:Oxytocin_receptor_antagonists.
- L-368,899 subject Category:Tocolytics.
- L-368,899 hypernym Drug.
- L-368,899 type ChemicalSubstance.
- L-368,899 type Drug.
- L-368,899 type Chemical.
- L-368,899 type Drug.
- L-368,899 type Preparation.
- L-368,899 type ChemicalObject.
- L-368,899 type Thing.
- L-368,899 type Q8386.
- L-368,899 comment "L-368,899 is a drug used in scientific research which acts as a selective antagonist of the oxytocin receptor, with good selectivity over the related vasopressin receptors. Unlike related drugs such as the peripherally selective L-371,257, the oral bioavailabity is high and the brain penetration of L-368,899 is rapid, with selective accumulation in areas of the limbic system.".
- L-368,899 label "L-368,899".
- L-368,899 sameAs Q6456062.
- L-368,899 sameAs m.0glq9st.
- L-368,899 sameAs L-368,899.
- L-368,899 sameAs L-368,899.
- L-368,899 sameAs Q6456062.
- L-368,899 wasDerivedFrom L-368,899?oldid=667226345.
- L-368,899 depiction L-368,899_structure.png.
- L-368,899 isPrimaryTopicOf L-368,899.