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- Kringle_domain abstract "Kringle Domains are autonomous protein domains that fold into large loops stabilized by 3 disulfide linkages. These are important in protein-protein interactions with blood coagulation factors. The name Kringle comes from the Scandinavian pastry that these structures resemble.Kringle domains have been found in plasminogen, hepatocyte growth factors, prothrombin, and apolipoprotein(a).Kringles are found throughout the blood clotting and fibrinolytic proteins. Kringle domains are believed to play a role in binding mediators (e.g., membranes, other proteins or phospholipids), and in the regulation of proteolytic activity. Kringle domains are characterised by a triple loop, 3-disulfide bridge structure, whose conformation is defined by a number of hydrogen bonds and small pieces of anti-parallel beta-sheet. They are found in a varying number of copies in some plasma proteins including prothrombin and urokinase-type plasminogenactivator, which are serine proteases belonging to MEROPS peptidase family S1A.".
- Kringle_domain symbol "Kringle".
- Kringle_domain thumbnail 1nl2_opm.png?width=300.
- Kringle_domain wikiPageExternalLink do_annotation.pl?DOMAIN=KR.
- Kringle_domain wikiPageExternalLink nicedoc.pl?PDOC00020.
- Kringle_domain wikiPageID "2564914".
- Kringle_domain wikiPageLength "4852".
- Kringle_domain wikiPageOutDegree "35".
- Kringle_domain wikiPageRevisionID "617731843".
- Kringle_domain wikiPageWikiLink Activating_transcription_factor_2.
- Kringle_domain wikiPageWikiLink Blood.
- Kringle_domain wikiPageWikiLink Category:Peripheral_membrane_proteins.
- Kringle_domain wikiPageWikiLink Category:Protein_domains.
- Kringle_domain wikiPageWikiLink Coagulation.
- Kringle_domain wikiPageWikiLink Factor_XII.
- Kringle_domain wikiPageWikiLink Growth_factor.
- Kringle_domain wikiPageWikiLink HABP2.
- Kringle_domain wikiPageWikiLink HGFAC.
- Kringle_domain wikiPageWikiLink Hepatocyte.
- Kringle_domain wikiPageWikiLink Hepatocyte_growth_factor.
- Kringle_domain wikiPageWikiLink KREMEN1.
- Kringle_domain wikiPageWikiLink KREMEN2.
- Kringle_domain wikiPageWikiLink Kringle.
- Kringle_domain wikiPageWikiLink LPAL2.
- Kringle_domain wikiPageWikiLink Lipoprotein(a).
- Kringle_domain wikiPageWikiLink Lysophosphatidylserine.
- Kringle_domain wikiPageWikiLink MST1.
- Kringle_domain wikiPageWikiLink PIK3IP1.
- Kringle_domain wikiPageWikiLink PLAU.
- Kringle_domain wikiPageWikiLink PROSITE.
- Kringle_domain wikiPageWikiLink PRSS12.
- Kringle_domain wikiPageWikiLink Plasmin.
- Kringle_domain wikiPageWikiLink Protein.
- Kringle_domain wikiPageWikiLink Protein_domain.
- Kringle_domain wikiPageWikiLink ROR1.
- Kringle_domain wikiPageWikiLink ROR2.
- Kringle_domain wikiPageWikiLink Scandinavia.
- Kringle_domain wikiPageWikiLink Thrombin.
- Kringle_domain wikiPageWikiLink Tissue_plasminogen_activator.
- Kringle_domain wikiPageWikiLinkText "Kringle domain".
- Kringle_domain wikiPageWikiLinkText "Kringle domains (KR1-5)".
- Kringle_domain wikiPageWikiLinkText "Kringle".
- Kringle_domain wikiPageWikiLinkText "kringle domain".
- Kringle_domain wikiPageWikiLinkText "kringle".
- Kringle_domain caption "Bovine prothrombin fragment 1 in complex with calcium and lysophosphatidylserine".
- Kringle_domain cdd "cd00108".
- Kringle_domain interpro "IPR000001".
- Kringle_domain opmProtein "1".
- Kringle_domain pdb "B:215-296 A:215-296 :215-296 :70-151 :70-151 B:481-560 B:103-181 A:103-181 :103-181 B:103-181 :103-181 :103-181 :377-454 B:377-454 :377-454 :377-454 :4124-4201 :4124-4201 :4124-4201 A:3676-3753 A:3782-3859 B:185-262 A:185-262 F:128-206 B:128-206 D:128-206 B:128-206 B:128-206 A:109-187 :109-187 A:109-187 :109-187 D:214-292 P:214-292 P:213-291".
- Kringle_domain pfam "PF00051".
- Kringle_domain prosite "PDOC00020".
- Kringle_domain scop "1".
- Kringle_domain smart "KR".
- Kringle_domain symbol "Kringle".
- Kringle_domain wikiPageUsesTemplate Template:PDB3.
- Kringle_domain wikiPageUsesTemplate Template:Pfam_box.
- Kringle_domain wikiPageUsesTemplate Template:Protein_domains.
- Kringle_domain wikiPageUsesTemplate Template:Reflist.
- Kringle_domain subject Category:Peripheral_membrane_proteins.
- Kringle_domain subject Category:Protein_domains.
- Kringle_domain hypernym Domains.
- Kringle_domain type Biomolecule.
- Kringle_domain type Protein.
- Kringle_domain type Chemical.
- Kringle_domain type Domain.
- Kringle_domain type Thing.
- Kringle_domain type Q206229.
- Kringle_domain type Q8054.
- Kringle_domain comment "Kringle Domains are autonomous protein domains that fold into large loops stabilized by 3 disulfide linkages. These are important in protein-protein interactions with blood coagulation factors. The name Kringle comes from the Scandinavian pastry that these structures resemble.Kringle domains have been found in plasminogen, hepatocyte growth factors, prothrombin, and apolipoprotein(a).Kringles are found throughout the blood clotting and fibrinolytic proteins.".
- Kringle_domain label "Kringle domain".
- Kringle_domain sameAs Q4864516.
- Kringle_domain sameAs Dominio_Kringle.
- Kringle_domain sameAs m.07nc57.
- Kringle_domain sameAs Kringl_domen.
- Kringle_domain sameAs Kringl_domen.
- Kringle_domain sameAs Q4864516.
- Kringle_domain wasDerivedFrom Kringle_domain?oldid=617731843.
- Kringle_domain depiction 1nl2_opm.png.
- Kringle_domain isPrimaryTopicOf Kringle_domain.