Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Kinetochore> ?p ?o }
- Kinetochore abstract "The kinetochore /kɪˈnɛtəkɔər/ is a protein structure on chromatids where the spindle fibers attach during cell division to pull sister chromatids apart. Their proteins help to hold the sister chromatids together and also play a role in chromosome editing.The kinetochore forms in eukaryotes, assembles on the centromere and links the chromosome to microtubule polymers from the mitotic spindle during mitosis and meiosis.Monocentric organisms, including vertebrates, fungi, and most plants, have a single centromeric region on each chromosome which assembles one kinetochore. Holocentric organisms, such as nematodes and some plants, assemble a kinetochore along the entire length of a chromosome.The kinetochore contains two regions: an inner kinetochore, which is tightly associated with the centromere DNA, assembled in a specialized form of chromatin persistent throughout the cell cycle; an outer kinetochore, which interacts with microtubules; the outer kinetochore is a very dynamic structure, with many identical components, which are assembled and functional only during cell division.Kinetochores start, control and supervise the striking movements of chromosomes during cell division. During mitosis, which occurs after chromosomes are duplicated during S phase, two sister chromatids are held together, each with its own kinetochore, which face in opposing directions and attach to opposite poles of the mitotic spindle. Following the transition from metaphase to anaphase, the sister chromatids separate from each other, and the individual kinetochores on each chromatid drive their movement to the spindle poles that will define the two new daughter cells. Thus, the kinetochore is essential for the chromosome segregation that is classically associated with mitosis and meiosis.Even the simplest kinetochores consist of more than 19 different proteins. Many of these proteins are conserved between eukaryotic species, including a specialized histone H3 variant (called CENP-A or CenH3) which helps the kinetochore associate with DNA. Other proteins in the kinetochore attach it to the microtubules (MTs) of the mitotic spindle. There are also motor proteins, including both dynein and kinesin, which generate forces that move chromosomes during mitosis. Other proteins, such as Mad2, monitor the microtubule attachment as well as the tension between sister kinetochores and activate the spindle checkpoint to arrest the cell cycle when either of these is absent.In summary, kinetochore functions include anchoring of chromosomes to MTs in the spindle, verification of anchoring, activation of the spindle checkpoint and participation in force generation to propel chromosome movement during cell division.On the other hand, MTs are metastable polymers made of α- and β-tubulin, alternating between growing and shrinking phases, a phenomenon known as dynamic instability. MTs are highly dynamic structures, whose behavior is integrated with kinetochore function to control chromosome movement and segregation.".
- Kinetochore thumbnail Kinetochore.jpg?width=300.
- Kinetochore wikiPageID "998893".
- Kinetochore wikiPageLength "66952".
- Kinetochore wikiPageOutDegree "135".
- Kinetochore wikiPageRevisionID "706044963".
- Kinetochore wikiPageWikiLink Adenomatous_polyposis_coli.
- Kinetochore wikiPageWikiLink Adenosine_triphosphate.
- Kinetochore wikiPageWikiLink Anaphase.
- Kinetochore wikiPageWikiLink Anaphase-promoting_complex.
- Kinetochore wikiPageWikiLink Aneuploidy.
- Kinetochore wikiPageWikiLink Antibody.
- Kinetochore wikiPageWikiLink Apoptosis.
- Kinetochore wikiPageWikiLink BUB1.
- Kinetochore wikiPageWikiLink BUB1B.
- Kinetochore wikiPageWikiLink BUB3.
- Kinetochore wikiPageWikiLink CDC20.
- Kinetochore wikiPageWikiLink CENPA.
- Kinetochore wikiPageWikiLink CENPC.
- Kinetochore wikiPageWikiLink CENPF.
- Kinetochore wikiPageWikiLink CENPH.
- Kinetochore wikiPageWikiLink CENPI.
- Kinetochore wikiPageWikiLink Category:Organelles.
- Kinetochore wikiPageWikiLink Cell_cycle.
- Kinetochore wikiPageWikiLink Centriole.
- Kinetochore wikiPageWikiLink Centromere.
- Kinetochore wikiPageWikiLink Centromere_protein_B.
- Kinetochore wikiPageWikiLink Centromere_protein_E.
- Kinetochore wikiPageWikiLink Centrosome.
- Kinetochore wikiPageWikiLink Chromatid.
- Kinetochore wikiPageWikiLink Chromosome.
- Kinetochore wikiPageWikiLink Cohesin.
- Kinetochore wikiPageWikiLink Condensin.
- Kinetochore wikiPageWikiLink DNA_replication.
- Kinetochore wikiPageWikiLink Dynein.
- Kinetochore wikiPageWikiLink EB1.
- Kinetochore wikiPageWikiLink Electron_microscope.
- Kinetochore wikiPageWikiLink Eukaryote.
- Kinetochore wikiPageWikiLink Gene_knockout.
- Kinetochore wikiPageWikiLink HeLa.
- Kinetochore wikiPageWikiLink Heterochromatin.
- Kinetochore wikiPageWikiLink Histone.
- Kinetochore wikiPageWikiLink Kinase.
- Kinetochore wikiPageWikiLink Kinesin.
- Kinetochore wikiPageWikiLink Laser.
- Kinetochore wikiPageWikiLink MAD2L1.
- Kinetochore wikiPageWikiLink Mad1.
- Kinetochore wikiPageWikiLink Mad2.
- Kinetochore wikiPageWikiLink Meiosis.
- Kinetochore wikiPageWikiLink Metaphase.
- Kinetochore wikiPageWikiLink Microscopy.
- Kinetochore wikiPageWikiLink Microtubule.
- Kinetochore wikiPageWikiLink Mitosis.
- Kinetochore wikiPageWikiLink Molecular_motor.
- Kinetochore wikiPageWikiLink Motor_protein.
- Kinetochore wikiPageWikiLink Mullers_morphs.
- Kinetochore wikiPageWikiLink NDC80.
- Kinetochore wikiPageWikiLink NUF2.
- Kinetochore wikiPageWikiLink Nematode.
- Kinetochore wikiPageWikiLink Nuclear_membrane.
- Kinetochore wikiPageWikiLink Nuclear_pore.
- Kinetochore wikiPageWikiLink Nucleosome.
- Kinetochore wikiPageWikiLink ORC2.
- Kinetochore wikiPageWikiLink Origin_recognition_complex.
- Kinetochore wikiPageWikiLink RANBP2.
- Kinetochore wikiPageWikiLink RANGAP1.
- Kinetochore wikiPageWikiLink RNA_interference.
- Kinetochore wikiPageWikiLink Ran_(gene).
- Kinetochore wikiPageWikiLink SPC24.
- Kinetochore wikiPageWikiLink SPC25.
- Kinetochore wikiPageWikiLink S_phase.
- Kinetochore wikiPageWikiLink Saccharomyces_cerevisiae.
- Kinetochore wikiPageWikiLink Satellite_DNA.
- Kinetochore wikiPageWikiLink Shugoshin.
- Kinetochore wikiPageWikiLink Sister_chromatids.
- Kinetochore wikiPageWikiLink Spindle_apparatus.
- Kinetochore wikiPageWikiLink Spindle_checkpoint.
- Kinetochore wikiPageWikiLink ZW10.
- Kinetochore wikiPageWikiLink File:Endogenous_hMad1.png.
- Kinetochore wikiPageWikiLink File:Kinetochore.jpg.
- Kinetochore wikiPageWikiLink File:Kinetochore_vertebrates-en.png.
- Kinetochore wikiPageWikiLink File:MT_attachment_configuration-en.png.
- Kinetochore wikiPageWikiLink File:Metaphase.jpg.
- Kinetochore wikiPageWikiLink File:SiCENP-E_metaphase.png.
- Kinetochore wikiPageWikiLink File:Spindle_chromosomes-en.png.
- Kinetochore wikiPageWikiLinkText "Kinetochore research".
- Kinetochore wikiPageWikiLinkText "Kinetochore".
- Kinetochore wikiPageWikiLinkText "kinetochore".
- Kinetochore wikiPageWikiLinkText "merotelic".
- Kinetochore wikiPageWikiLinkText "syntelic".
- Kinetochore wikiPageUsesTemplate Template:According_to_whom.
- Kinetochore wikiPageUsesTemplate Template:IPAc-en.
- Kinetochore wikiPageUsesTemplate Template:Main.
- Kinetochore wikiPageUsesTemplate Template:MeshNumber.
- Kinetochore wikiPageUsesTemplate Template:Reflist.
- Kinetochore wikiPageUsesTemplate Template:See_also.
- Kinetochore subject Category:Organelles.
- Kinetochore hypernym Structure.
- Kinetochore type Building.
- Kinetochore type Thing.