Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Kainic_acid> ?p ?o }
Showing triples 1 to 96 of
96
with 100 triples per page.
- Kainic_acid abstract "Kainic acid (kainate) is a natural marine acid present in some seaweed. Kainic acid is a potent neuroexcitatory amino acid that acts by activating receptors for glutamate, the principal excitatory neurotransmitter in the central nervous system. Glutamate is produced by the cell’s metabolic processes and there are four major classifications of glutamate receptors: NMDA receptors, AMPA receptors, kainate receptors, and the metabotropic glutamate receptors. Kainic acid is an agonist for kainate receptors, a type of ionotropic glutamate receptor. Kainate receptors likely control a sodium channel that produces excitatory postsynaptic potentials (EPSPs) when glutamate binds.Kainic acid is commonly injected into laboratory animal models to study the effects of experimental ablation. Kainic acid is a direct agonist of the glutamic kainate receptors and large doses of concentrated solutions produce immediate neuronal death by overstimulating neurons to death. Such damage and death of neurons is referred to as an excitotoxic lesion. Thus, in large, concentrated doses kainic acid can be considered a neurotoxin, and in small doses of dilute solution kainic acid will chemically stimulate neurons.Electrical stimulation of designated areas of the brain are generally administered by passing an electric current through a wire that is inserted into the brain to lesion a particular area of the brain. Electrical stimulation indiscriminately destroys anything in the vicinity of the electrode tip, including neural bodies and axons of neurons passing through; therefore it is difficult to attribute the effects of the lesion to a single area. Chemical stimulation is typically administered through a cannula that is inserted into the brain via stereotactic surgery. Chemical stimulation, while more complicated than electrical stimulation, has the distinct advantage of activating cell bodies, but not nearby axons, because only cell bodies and subsequent dendrites contain glutamate receptors. Therefore, chemical stimulation by kainic acid is more localized than electrical stimulation. It is important to note that both chemical and electrical lesions potentially cause additional damage to the brain due to the very nature of the inserted electrode or cannula. Therefore, the most effective ablation studies are performed in comparison to a sham lesion that duplicates all the steps of producing a brain lesion except the one that actually causes the brain damage, that is, injection of kainic acid or administration of an electrical shock.".
- Kainic_acid iupacName "(2S,3S,4S)-3-(Carboxymethyl)-4-prop-1-en-2-ylpyrrolidine-2-carboxylic acid".
- Kainic_acid thumbnail Kainic_acid.png?width=300.
- Kainic_acid wikiPageExternalLink kainate_1.htm.
- Kainic_acid wikiPageID "2669043".
- Kainic_acid wikiPageLength "7905".
- Kainic_acid wikiPageOutDegree "28".
- Kainic_acid wikiPageRevisionID "668364797".
- Kainic_acid wikiPageWikiLink Ablative_brain_surgery.
- Kainic_acid wikiPageWikiLink Agonist.
- Kainic_acid wikiPageWikiLink Alzheimers_disease.
- Kainic_acid wikiPageWikiLink Anthelmintic.
- Kainic_acid wikiPageWikiLink Category:Amino_acids.
- Kainic_acid wikiPageWikiLink Category:Convulsants.
- Kainic_acid wikiPageWikiLink Category:Kainate_receptor_agonists.
- Kainic_acid wikiPageWikiLink Category:Neurotoxins.
- Kainic_acid wikiPageWikiLink Category:Pyrrolidines.
- Kainic_acid wikiPageWikiLink Central_nervous_system.
- Kainic_acid wikiPageWikiLink Domoic_acid.
- Kainic_acid wikiPageWikiLink Epilepsy.
- Kainic_acid wikiPageWikiLink Excitatory_postsynaptic_potential.
- Kainic_acid wikiPageWikiLink Excitotoxicity.
- Kainic_acid wikiPageWikiLink Glutamic_acid.
- Kainic_acid wikiPageWikiLink Ionotropic_glutamate_receptor.
- Kainic_acid wikiPageWikiLink Japan.
- Kainic_acid wikiPageWikiLink Kainate_receptor.
- Kainic_acid wikiPageWikiLink Lesion.
- Kainic_acid wikiPageWikiLink Neuroscience.
- Kainic_acid wikiPageWikiLink Seaweed.
- Kainic_acid wikiPageWikiLink Stereotactic_surgery.
- Kainic_acid wikiPageWikiLink File:KA_time_series.jpg.
- Kainic_acid wikiPageWikiLinkText "Kainic acid".
- Kainic_acid wikiPageWikiLinkText "kainate".
- Kainic_acid wikiPageWikiLinkText "kainic acid".
- Kainic_acid imagefile "Kainic acid.png".
- Kainic_acid imagename "Stereo, skeletal formula of kainic acid".
- Kainic_acid imagesize "200".
- Kainic_acid iupacname "-3".
- Kainic_acid othernames "-3".
- Kainic_acid verifiedfields "changed".
- Kainic_acid verifiedrevid "477496607".
- Kainic_acid watchedfields "changed".
- Kainic_acid wikiPageUsesTemplate Template:Authority_control.
- Kainic_acid wikiPageUsesTemplate Template:Cascite.
- Kainic_acid wikiPageUsesTemplate Template:Chembox.
- Kainic_acid wikiPageUsesTemplate Template:Chembox_Identifiers.
- Kainic_acid wikiPageUsesTemplate Template:Chembox_Properties.
- Kainic_acid wikiPageUsesTemplate Template:Chembox_Structure.
- Kainic_acid wikiPageUsesTemplate Template:Chemboximage.
- Kainic_acid wikiPageUsesTemplate Template:Chemspidercite.
- Kainic_acid wikiPageUsesTemplate Template:Citation_needed.
- Kainic_acid wikiPageUsesTemplate Template:Ebicite.
- Kainic_acid wikiPageUsesTemplate Template:Fdacite.
- Kainic_acid wikiPageUsesTemplate Template:Glutamatergics.
- Kainic_acid wikiPageUsesTemplate Template:Keggcite.
- Kainic_acid wikiPageUsesTemplate Template:Reflist.
- Kainic_acid wikiPageUsesTemplate Template:Stdinchicite.
- Kainic_acid subject Category:Amino_acids.
- Kainic_acid subject Category:Convulsants.
- Kainic_acid subject Category:Kainate_receptor_agonists.
- Kainic_acid subject Category:Neurotoxins.
- Kainic_acid subject Category:Pyrrolidines.
- Kainic_acid hypernym Acid.
- Kainic_acid type Biomolecule.
- Kainic_acid type ChemicalCompound.
- Kainic_acid type ChemicalSubstance.
- Kainic_acid type Biomolecule.
- Kainic_acid type Chemical.
- Kainic_acid type Heterocycle.
- Kainic_acid type Modulator.
- Kainic_acid type Redirect.
- Kainic_acid type ChemicalObject.
- Kainic_acid type Thing.
- Kainic_acid type Q11173.
- Kainic_acid comment "Kainic acid (kainate) is a natural marine acid present in some seaweed. Kainic acid is a potent neuroexcitatory amino acid that acts by activating receptors for glutamate, the principal excitatory neurotransmitter in the central nervous system. Glutamate is produced by the cell’s metabolic processes and there are four major classifications of glutamate receptors: NMDA receptors, AMPA receptors, kainate receptors, and the metabotropic glutamate receptors.".
- Kainic_acid label "Kainic acid".
- Kainic_acid sameAs Q390239.
- Kainic_acid sameAs Kainic_acid.
- Kainic_acid sameAs Kainsäure.
- Kainic_acid sameAs Ácido_kaínico.
- Kainic_acid sameAs کاینیک_اسید.
- Kainic_acid sameAs Acide_kaïnique.
- Kainic_acid sameAs Kainsav.
- Kainic_acid sameAs Acido_kainico.
- Kainic_acid sameAs カイニン酸.
- Kainic_acid sameAs Kaïnezuur.
- Kainic_acid sameAs m.07wq70.
- Kainic_acid sameAs Каиновая_кислота.
- Kainic_acid sameAs Kainska_kiselina.
- Kainic_acid sameAs Kainska_kiselina.
- Kainic_acid sameAs Каїнова_кислота.
- Kainic_acid sameAs Q390239.
- Kainic_acid sameAs 卡英酸.
- Kainic_acid wasDerivedFrom Kainic_acid?oldid=668364797.
- Kainic_acid depiction Kainic_acid.png.
- Kainic_acid isPrimaryTopicOf Kainic_acid.