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- KCNQ1OT1 abstract "KCNQ1 overlapping transcript 1, also known as KCNQ1OT1, is a long non-coding RNA gene found in the KCNQ1 locus. This locus consists of 8-10 protein-coding genes, specifically expressed from the maternal allele (including the KCNQ1 gene), and the paternally expressed non-coding RNA gene KCNQ1OT1. KCNQ1OT1 is a nuclear, 91 kb transcript, found in close proximity to the nucleolus in certain cell types.It interacts with chromatin, the histone methyltransferase G9a (responsible for the mono- and dimethylation of histone 3 lysine 9, H3K9), and the Polycomb Repressive Complex 2, PRC2, (responsible for the trimethylation of H3K27). It plays an important role in the transcriptional silencing of the KCNQ1 locus by regulating histone methylation. An 890 bp region at the 5' end of KCNQ1OT1 acts as a silencing domain. This region regulates CpG methylation levels of somatically acquired differentially methylated regions (DMRs), mediates the interaction of KCNQ1OT1 with chromatin and with DNA (cytosine-5)-methyltransferase 1 (DNMT1), but does not affect the interactions of histone methyltransferases with KCNQ1OT1.".
- KCNQ1OT1 entrezgene "10984".
- KCNQ1OT1 wikiPageExternalLink nature377_3.pdf.
- KCNQ1OT1 wikiPageID "14800644".
- KCNQ1OT1 wikiPageLength "10304".
- KCNQ1OT1 wikiPageOutDegree "18".
- KCNQ1OT1 wikiPageRevisionID "704254883".
- KCNQ1OT1 wikiPageWikiLink Base_pair.
- KCNQ1OT1 wikiPageWikiLink Beckwith–Wiedemann_syndrome.
- KCNQ1OT1 wikiPageWikiLink Category:Non-coding_RNA.
- KCNQ1OT1 wikiPageWikiLink Chromatin.
- KCNQ1OT1 wikiPageWikiLink DNA_methylation.
- KCNQ1OT1 wikiPageWikiLink DNMT1.
- KCNQ1OT1 wikiPageWikiLink Directionality_(molecular_biology).
- KCNQ1OT1 wikiPageWikiLink Gene.
- KCNQ1OT1 wikiPageWikiLink Gene_silencing.
- KCNQ1OT1 wikiPageWikiLink Genomic_imprinting.
- KCNQ1OT1 wikiPageWikiLink Histone_methyltransferase.
- KCNQ1OT1 wikiPageWikiLink KvLQT1.
- KCNQ1OT1 wikiPageWikiLink Locus_(genetics).
- KCNQ1OT1 wikiPageWikiLink Long_non-coding_RNA.
- KCNQ1OT1 wikiPageWikiLink Nucleolus.
- KCNQ1OT1 wikiPageWikiLink PRC2.
- KCNQ1OT1 wikiPageWikiLink Somatic_(biology).
- KCNQ1OT1 wikiPageWikiLinkText "DMR1".
- KCNQ1OT1 wikiPageWikiLinkText "KCNQ1OT1".
- KCNQ1OT1 wikiPageWikiLinkText "Kcnq1ot1".
- KCNQ1OT1 wikiPageUsesTemplate Template:Cite_journal.
- KCNQ1OT1 wikiPageUsesTemplate Template:PBB.
- KCNQ1OT1 wikiPageUsesTemplate Template:Protein-stub.
- KCNQ1OT1 wikiPageUsesTemplate Template:Refbegin.
- KCNQ1OT1 wikiPageUsesTemplate Template:Refend.
- KCNQ1OT1 wikiPageUsesTemplate Template:Reflist.
- KCNQ1OT1 subject Category:Non-coding_RNA.
- KCNQ1OT1 hypernym Gene.
- KCNQ1OT1 type Biomolecule.
- KCNQ1OT1 type Protein.
- KCNQ1OT1 type Thing.
- KCNQ1OT1 type Q206229.
- KCNQ1OT1 type Q8054.
- KCNQ1OT1 comment "KCNQ1 overlapping transcript 1, also known as KCNQ1OT1, is a long non-coding RNA gene found in the KCNQ1 locus. This locus consists of 8-10 protein-coding genes, specifically expressed from the maternal allele (including the KCNQ1 gene), and the paternally expressed non-coding RNA gene KCNQ1OT1.".
- KCNQ1OT1 label "KCNQ1OT1".
- KCNQ1OT1 sameAs Q18036003.
- KCNQ1OT1 sameAs m.03gyfym.
- KCNQ1OT1 sameAs Q18036003.
- KCNQ1OT1 wasDerivedFrom KCNQ1OT1?oldid=704254883.
- KCNQ1OT1 isPrimaryTopicOf KCNQ1OT1.